1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE
- Product Name
- 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE
- CAS No.
- 10394-38-4
- Chemical Name
- 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE
- Synonyms
- NSC 240760;1-Methylbenzimidazol-5-amine;5-Amino-1-methylbenzimidazole;1-Methylbenzoimidazol-5-amine;1-Methyl-5-aminobenzimidazole;1-methylbenzimidazole-5-amine;1-methyl-1H-benzimidazol-5-amine;5-Amino-1-methyl-1H-benzimidazole;5-Amino-1-methylbenzimidazole,97%;1-Methyl-1H-1,3-benzodiazol-5-aMine
- CBNumber
- CB5835122
- Molecular Formula
- C8H9N3
- Formula Weight
- 147.18
- MOL File
- 10394-38-4.mol
1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE Property
- Melting point:
- 158-159 °C
- Boiling point:
- 348.6±34.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- Solid
- pka
- 6.35±0.10(Predicted)
- Appearance
- Light brown to black Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- OR301135
- Product name
- 5-Amino-1-methyl-1H-benzimidazole
- Packaging
- 250mg
- Price
- $56
- Updated
- 2021/12/16
- Product number
- 076429
- Product name
- 1-Methylbenzoimidazol-5-amine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $278
- Updated
- 2021/12/16
- Product number
- 3H30-1-35
- Product name
- 1-Methylbenzoimidazol-5-amine
- Purity
- 95%
- Packaging
- 1g
- Price
- $164
- Updated
- 2021/12/16
- Product number
- X8683
- Product name
- 1-Methyl-1H-benzo[d]imidazol-5-amine
- Packaging
- 1g
- Price
- $170
- Updated
- 2021/12/16
- Product number
- 3H30-1-35
- Product name
- 1-Methylbenzoimidazol-5-amine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $66
- Updated
- 2021/12/16
1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE Chemical Properties,Usage,Production
Uses
1-Methyl-5-aminobenzimidazole is used in the synthesis of usnic acid derivatives as tau-aggregation and neuroinflammation inhibitor.
Synthesis
5381-78-2
10394-38-4
Example B23: 1-methyl-5-nitro-1H-benzo[d]imidazole (prepared according to the method described in WO 2005/092899; 1.14 g, 6.43 mmol) was dissolved in ethanol (50 ml) and stirred at room temperature under hydrogen (1 atm) atmosphere. 10% Pd/C catalyst (50 wt% water, 1.37 g, 0.643 mmol) was added. After 18 h of reaction, the reaction mixture was filtered through diatomaceous earth and rinsed with ethanol. The filtrates were combined and concentrated to afford the crude product 1-methyl-1H-benzo[d]imidazol-5-amine (1.02 g, 108% yield) as a dark orange oil, which was used directly in the next step of the reaction.1H NMR (400 MHz, DMSO-d6) δ 7.87 (s, 1H), 7.17 (d, J=8.4 Hz, 1H), 6.75 (d, J=2.0 Hz, 1H), 6.59 (dd, J=2.0 and 8.4 Hz, 1H), 4.73 (brs, 2H), 3.69 (s, 3H); MS (ESI) m/z: 148.0 (M+H+). Using a method similar to Example B22, 1-methyl-1H-benzo[d]imidazol-5-amine (0.50 g, 3.4 mmol), NaNO2 (0.28 g, 4.1 mmol), SnCl2-2H2O (2.8 g, 14 mmol), and 4-methyl-3-oxopentanenitrile (0.45 g, 4.1 mmol) were reacted to give the crude product 3-Isopropyl-1-(1-methyl-1H-benzo[d]imidazol-5-yl)-1H-pyrazol-5-amine (0.63 g, 73% yield), as a foam, was used directly in the next step of the reaction.1H NMR (400 MHz, DMSO-d6): δ 8.22 (s, 1H), 7.72 (dd, J=0.40 and 1.2 Hz, 1H), and 7.60 (dd, J=0.40 and 8.4 Hz, 1H), 7.42 (dd, J=2.0 and 8.4 Hz, 1H), 5.32 (s, 1H), 5.08 (brs, 2H), 3.85 (s, 3H), 2.75 (septet, J=6.8 Hz, 1H), 1.16 (d, J=6.8 Hz, 6H); MS ( ESI) m/z: 250.0 (M+H+).
References
[1] Patent: US2008/90856, 2008, A1. Location in patent: Page/Page column 46-47
[2] Patent: US2007/27184, 2007, A1. Location in patent: Page/Page column 20
[3] Journal of Pharmacy and Pharmacology, 1951, vol. 3, p. 420,424
[4] Gazzetta Chimica Italiana, 1955, vol. 85, p. 981,984
[5] Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 3, p. 713 - 724
1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE manufacturers
- Product
- 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE 10394-38-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20