ChemicalBook > CAS DataBase List > (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN

(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN

Product Name
(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN
CAS No.
1000578-26-6
Chemical Name
(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN
Synonyms
AS 19;AS-19,AS19;(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN;(2S)-N,N-Dimethyl-5-(1,3,5-trimethyl-4-pyrazolyl)-1,2,3,4-tetrahydronaphthalen-2-amine;(S)-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine;2-Naphthalenamine, 1,2,3,4-tetrahydro-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-, (2S)-
CBNumber
CB5846829
Molecular Formula
C18H25N3
Formula Weight
283.41
MOL File
Mol file
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(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN Property

Boiling point:
413.3±45.0 °C(Predicted)
Density 
1.09±0.1 g/cm3(Predicted)
storage temp. 
Desiccate at -20°C
solubility 
<28.34mg/ml in ethanol; <28.34mg/ml in DMSO
form 
oil
pka
9.20±0.20(Predicted)
color 
Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

Alfa Aesar
Product number
J64218
Product name
AS 19
Packaging
10mg
Price
$243
Updated
2021/12/16
Cayman Chemical
Product number
20642
Product name
AS 19
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
20642
Product name
AS 19
Packaging
10mg
Price
$249
Updated
2024/03/01
Cayman Chemical
Product number
20642
Product name
AS 19
Packaging
5mg
Price
$193
Updated
2024/03/01
Tocris
Product number
1968
Product name
AS 19
Purity
≥98%(HPLC)
Packaging
10
Price
$223
Updated
2021/12/16
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(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN Chemical Properties,Usage,Production

Uses

A potent 5-HT7 receptor agonist

Biological Activity

Reported potent 5-HT 7 receptor agonist (IC 50 = 0.83 nM). In vivo, enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia.

storage

Desiccate at -20°C

References

[1]. perez-garcía gs and meneses a. effects of the potential 5-ht7 receptor agonist as 19 in an autoshaping learning task. behav brain res, 2005, 163(1):136-40.
[2]. thomas dr and hagan jj. 5-ht7 receptors. current drug targets-cns & neurological disorders, 2004, 3(1): 81-90.
[3]. ulugol a, oltulu c, gunduz o, et al. 5-ht7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice. pharmacol biochem behav, 2012, 102(2):344-8.
[4]. león-ponte m, ahern gp and o'connell pj. serotonin provides an accessory signal to enhance t-cell activation by signaling through the 5-ht7 receptor. blood, 2007, 109(8):3139-46.
[5]. hoffman ms and mitchell gs. spinal 5-ht7 receptor activation induces long-lasting phrenic motor facilitation. j physiol, 2011, 589(pt 6):1397-407.

(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN Suppliers

China 20 United Kingdom 1 United States 8 USA 1 Global 30
Tocris Bioscience
Tel
--
Fax
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Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

1000578-26-6, (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALINRelated Search:

Cloxacillin-13C4 SodiuM Salt

  • AS 19
  • (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN
  • 2-Naphthalenamine, 1,2,3,4-tetrahydro-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-, (2S)-
  • (S)-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine
  • AS-19,AS19
  • (2S)-N,N-Dimethyl-5-(1,3,5-trimethyl-4-pyrazolyl)-1,2,3,4-tetrahydronaphthalen-2-amine
  • 1000578-26-6
  • Serotonin receptor
  • Potent 5-HT7 receptor agonist.