2-Chloro-4-bromobenzaldehyde
- Product Name
- 2-Chloro-4-bromobenzaldehyde
- CAS No.
- 158435-41-7
- Chemical Name
- 2-Chloro-4-bromobenzaldehyde
- Synonyms
- 4-BROMO-2-CHLOROBENZALDEHYDE;Chloro-4-bromobenzaldehyde;2-Chloro-4-bromobenzaldehyde;Benzaldehyde,4-broMo-2-chloro-;4-Bromo-2-chlorobenzaldehyde >2-Chloro-4-broMobenzaldehyde, 95+%;2-Chloro-4-bromobenzaldehyde, 97%min
- CBNumber
- CB5847619
- Molecular Formula
- C7H4BrClO
- Formula Weight
- 219.46
- MOL File
- 158435-41-7.mol
2-Chloro-4-bromobenzaldehyde Property
- Melting point:
- 74-76℃
- Boiling point:
- 271.3±25.0 °C(Predicted)
- Density
- 1.698±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Orange to Green
- Sensitive
- Air Sensitive
- CAS DataBase Reference
- 158435-41-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B3948
- Product name
- 4-Bromo-2-chlorobenzaldehyde
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $22
- Updated
- 2025/07/31
- Product number
- B3948
- Product name
- 4-Bromo-2-chlorobenzaldehyde
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- B699443
- Product name
- 4-Bromo-2-chlorobenzaldehyde
- Packaging
- 100mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- J98088
- Product name
- 2-Chloro-4-bromobenzaldehyde
- Packaging
- 5g
- Price
- $24
- Updated
- 2021/12/16
- Product number
- 072737
- Product name
- 2-Chloro-4-bromobenzaldehyde
- Purity
- 95+%
- Packaging
- 5g
- Price
- $24
- Updated
- 2021/12/16
2-Chloro-4-bromobenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
Light yellow crystalline powder
Uses
4-Bromo-2-chlorobenzaldehyde is a useful research chemical for organic synthesis and other chemical processes.4-Bromo-2-chlorobenzaldehyde is used in preparation of Heterocyclic compounds as P2X3 antagonist and its intermediate.
Synthesis
185315-48-4
158435-41-7
General procedure for the synthesis of 2-chloro-4-bromobenzaldehyde from (4-bromo-2-chlorophenyl)methanol: Oxalyl chloride (6.9 g, 54 mmol, 1.3 eq.) was dissolved in dichloromethane (DCM, 153 mL) and the solution was cooled to -78 °C. A solution of DCM (57 mL) in dimethyl sulfoxide (DMSO, 4.72 mL, 66.5 mmol, 1.6 eq.) was slowly added dropwise to the cooled solution at -78 °C and stirred for 15 min. (4-Bromo-2-chlorophenyl)methanol (Compound 43, 9.2 g, 41.5 mmol, 1.0 eq.) was dissolved in DCM (116 mL) and added drop-wise to the above cooled solution, keeping the temperature at -78 °C. Stirring was continued at -78 °C for 2 hours. Subsequently, triethylamine (TEA, 28.7 mL, 207 mmol, 5 eq.) was added to slowly warm the reaction mixture to room temperature. After stirring for 30 min at room temperature, the reaction mixture was diluted with DCM (300 mL), washed sequentially with saturated ammonium chloride (NH4Cl) solution and brine, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated in vacuum to afford 2-chloro-4-bromobenzaldehyde (Compound 44) in 96% yield (8.8 g).
References
[1] Patent: WO2008/51826, 2008, A2. Location in patent: Page/Page column 53; 54
[2] Patent: WO2008/103277, 2008, A2. Location in patent: Page/Page column 197
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 18, p. 7820 - 7834
[4] Patent: WO2013/75083, 2013, A1. Location in patent: Paragraph 006309; 00632
[5] Patent: US9206128, 2015, B2. Location in patent: Page/Page column 275; 276; 277
2-Chloro-4-bromobenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-4-bromobenzaldehyde manufacturers
- Product
- 2-Chloro-4-bromobenzaldehyde 158435-41-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-26
- Product
- 2-Chloro-4-bromobenzaldehyde 158435-41-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-09