Fidarestat

ChemicalBook > CAS DataBase List > Fidarestat

Product Name: Fidarestat
CAS No.: 136087-85-9
Chemical Name: Fidarestat
Synonyms: Aldos;Sk 860;CS-489;SNK-860;fidarestat;Fidarestat (SNK-860;(2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide;(2s,4s)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione;(2S,4S)-6-Fluoro-2',5'-dioxospiro[chromane-4,4'-imidazolidine]-2-carboxamide;(2s,4s)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[chromene-4,4'-imidazolidine]-2-carboxamide
CBNumber: CB5855234
Molecular Formula: C12H10FN3O4
Formula Weight: 279.22
MOL File: 136087-85-9.mol

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Fidarestat Property

Density: 1.61±0.1 g/cm3(Predicted)
solubility: DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml
form: A crystalline solid
pka: 8.46±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21756
Product name: Fidarestat
Purity: ≥98%
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 21756
Product name: Fidarestat
Purity: ≥98%
Packaging: 5mg
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 21756
Product name: Fidarestat
Purity: ≥98%
Packaging: 10mg
Price: $632
Updated: 2024/03/01

AK Scientific

Product number: V2050
Product name: Fidarestat
Packaging: 10mg
Price: $802
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002700
Product name: FIDARESTAT
Purity: 95.00%
Packaging: 100MG
Price: $2047.5
Updated: 2021/12/16

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Fidarestat Chemical Properties,Usage,Production

Uses

Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.

Biological Activity

Fidarestat (SNK 860) is an aldose reductase inhibitor with IC50 values of 26 nM, 33 μM and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively. Fidarestat (SNK 860) has the potential to study diabetes.

in vitro

Fidarestat (SNK-860; 1 or 4 mg/kg. po, daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats.

in vivo

Fidarestat is an inhibitor of aldose reductase, with IC ₅₀ s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively.

target

IC50: 26 nM (Aldose reductase), 33 μM (AKR1B10), 1.8 μM (V301L AKR1B10)

References

[1] Ruiz FX, et al. X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity. Chem Biol Interact. 2013 Feb 25;202(1-3):178-85. DOI:10.1016/j.cbi.2012.12.013
[2] Hotta N, et al. Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic rats. Exp Physiol. 1995 Nov;80(6):981-9. DOI:10.1113/expphysiol.1995.sp003909

Fidarestat Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fidarestat manufacturers

Career Henan Chemical Co

Product: Fidarestat 136087-85-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95--99%
Supply Ability: 1ton
Release date: 2020-01-03

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136087-85-9