Fidarestat
- Product Name
- Fidarestat
- CAS No.
- 136087-85-9
- Chemical Name
- Fidarestat
- Synonyms
- Aldos;Sk 860;CS-489;SNK-860;fidarestat;Fidarestat (SNK-860;(2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide;(2s,4s)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione;(2s,4s)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[chromene-4,4'-imidazolidine]-2-carboxamide;(2S,4S)-2,3-Dihydro-6-fluoro-2',5'-dioxospiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide
- CBNumber
- CB5855234
- Molecular Formula
- C12H10FN3O4
- Formula Weight
- 279.22
- MOL File
- 136087-85-9.mol
Fidarestat Property
- Density
- 1.61±0.1 g/cm3(Predicted)
- solubility
- DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml
- form
- A crystalline solid
- pka
- 8.46±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 21756
- Product name
- Fidarestat
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 21756
- Product name
- Fidarestat
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $356
- Updated
- 2024/03/01
- Product number
- 21756
- Product name
- Fidarestat
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $632
- Updated
- 2024/03/01
- Product number
- V2050
- Product name
- Fidarestat
- Packaging
- 10mg
- Price
- $802
- Updated
- 2021/12/16
- Product number
- API0002700
- Product name
- FIDARESTAT
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $2047.5
- Updated
- 2021/12/16
Fidarestat Chemical Properties,Usage,Production
Biological Activity
Fidarestat (SNK 860) is an aldose reductase inhibitor with IC50 values of 26 nM, 33 μM and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively. Fidarestat (SNK 860) has the potential to study diabetes.
in vitro
Fidarestat (SNK-860; 1 or 4 mg/kg. po, daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats.
in vivo
Fidarestat is an inhibitor of aldose reductase, with IC 50 s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively.
target
IC50: 26 nM (Aldose reductase), 33 μM (AKR1B10), 1.8 μM (V301L AKR1B10)
Fidarestat Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Fidarestat manufacturers
- Product
- Fidarestat 136087-85-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95--99%
- Supply Ability
- 1ton
- Release date
- 2020-01-03