Fidarestat
- Product Name
- Fidarestat
- CAS No.
- 136087-85-9
- Chemical Name
- Fidarestat
- Synonyms
- Aldos;Sk 860;CS-489;SNK-860;fidarestat;Fidarestat (SNK-860;(2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide;(2s,4s)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione;(2S,4S)-6-Fluoro-2',5'-dioxospiro[chromane-4,4'-imidazolidine]-2-carboxamide;(2s,4s)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[chromene-4,4'-imidazolidine]-2-carboxamide
- CBNumber
- CB5855234
- Molecular Formula
- C12H10FN3O4
- Formula Weight
- 279.22
- MOL File
- 136087-85-9.mol
Fidarestat Property
- Density
- 1.61±0.1 g/cm3(Predicted)
- solubility
- DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml
- form
- A crystalline solid
- pka
- 8.46±0.40(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 21756
- Product name
- Fidarestat
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 21756
- Product name
- Fidarestat
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $356
- Updated
- 2024/03/01
- Product number
- 21756
- Product name
- Fidarestat
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $632
- Updated
- 2024/03/01
- Product number
- V2050
- Product name
- Fidarestat
- Packaging
- 10mg
- Price
- $802
- Updated
- 2021/12/16
- Product number
- API0002700
- Product name
- FIDARESTAT
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $2047.5
- Updated
- 2021/12/16
Fidarestat Chemical Properties,Usage,Production
Uses
Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.
Biological Activity
Fidarestat (SNK 860) is an aldose reductase inhibitor with IC50 values of 26 nM, 33 μM and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively. Fidarestat (SNK 860) has the potential to study diabetes.
in vitro
Fidarestat (SNK-860; 1 or 4 mg/kg. po, daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats.
in vivo
Fidarestat is an inhibitor of aldose reductase, with IC 50 s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively.
target
IC50: 26 nM (Aldose reductase), 33 μM (AKR1B10), 1.8 μM (V301L AKR1B10)
References
[1] Ruiz FX, et al. X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity. Chem Biol Interact. 2013 Feb 25;202(1-3):178-85. DOI:10.1016/j.cbi.2012.12.013
[2] Hotta N, et al. Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic rats. Exp Physiol. 1995 Nov;80(6):981-9. DOI:10.1113/expphysiol.1995.sp003909
Fidarestat Preparation Products And Raw materials
Raw materials
Preparation Products
Fidarestat Suppliers
View Lastest Price from Fidarestat manufacturers
- Product
- Fidarestat 136087-85-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95--99%
- Supply Ability
- 1ton
- Release date
- 2020-01-03