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Fidarestat

Product Name
Fidarestat
CAS No.
136087-85-9
Chemical Name
Fidarestat
Synonyms
Aldos;Sk 860;CS-489;SNK-860;fidarestat;Fidarestat (SNK-860;(2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide;(2s,4s)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione;(2s,4s)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[chromene-4,4'-imidazolidine]-2-carboxamide;(2S,4S)-2,3-Dihydro-6-fluoro-2',5'-dioxospiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide
CBNumber
CB5855234
Molecular Formula
C12H10FN3O4
Formula Weight
279.22
MOL File
136087-85-9.mol
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Fidarestat Property

Density 
1.61±0.1 g/cm3(Predicted)
solubility 
DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml
form 
A crystalline solid
pka
8.46±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21756
Product name
Fidarestat
Purity
≥98%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
21756
Product name
Fidarestat
Purity
≥98%
Packaging
5mg
Price
$356
Updated
2024/03/01
Cayman Chemical
Product number
21756
Product name
Fidarestat
Purity
≥98%
Packaging
10mg
Price
$632
Updated
2024/03/01
AK Scientific
Product number
V2050
Product name
Fidarestat
Packaging
10mg
Price
$802
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002700
Product name
FIDARESTAT
Purity
95.00%
Packaging
100MG
Price
$2047.5
Updated
2021/12/16
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Fidarestat Chemical Properties,Usage,Production

Biological Activity

Fidarestat (SNK 860) is an aldose reductase inhibitor with IC50 values of 26 nM, 33 μM and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively. Fidarestat (SNK 860) has the potential to study diabetes.

in vitro

Fidarestat (SNK-860; 1 or 4 mg/kg. po, daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats.

in vivo

Fidarestat is an inhibitor of aldose reductase, with IC 50 s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively.

target

IC50: 26 nM (Aldose reductase), 33 μM (AKR1B10), 1.8 μM (V301L AKR1B10)

Fidarestat Preparation Products And Raw materials

Raw materials

Preparation Products

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Fidarestat Suppliers

China 44 India 2 Japan 1 United States 8 Global 55
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View Lastest Price from Fidarestat manufacturers

Career Henan Chemical Co
Product
Fidarestat 136087-85-9
Price
US $1.00/KG
Min. Order
1KG
Purity
95--99%
Supply Ability
1ton
Release date
2020-01-03

136087-85-9, FidarestatRelated Search:

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  • (2s,4s)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[chromene-4,4'-imidazolidine]-2-carboxamide
  • (2s,4s)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione
  • fidarestat
  • (2S,4S)-6-FLUORO-2'',5''-DIOXOSPIRO(3,4-DIHYDRO-2H-1-BENZOPYRAN-4,4''-IMIDAZOLIDINE)-2-CARBOXAMIDE
  • (2S,4S)-2,3-Dihydro-6-fluoro-2',5'-dioxospiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide
  • (2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide
  • SNK-860
  • Aldos
  • Sk 860
  • Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2-carboxamide, 2,3-dihydro-2',5'-dioxo-6-fluoro-, (2S-cis)-
  • Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2-carboxamide, 6-fluoro-2,3-dihydro-2',5'-dioxo-, (2S-cis)-
  • Fidarestat (SNK-860
  • CS-489
  • Spiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide, 6-fluoro-2,3-dihydro-2',5'-dioxo-, (2S,4S)-
  • FidarestatQ: What is Fidarestat Q: What is the CAS Number of Fidarestat Q: What is the storage condition of Fidarestat Q: What are the applications of Fidarestat
  • 136087-85-9