ChemicalBook > CAS DataBase List > Tacedinaline

Tacedinaline

Product Name
Tacedinaline
CAS No.
112522-64-2
Chemical Name
Tacedinaline
Synonyms
acetyldinaline;CI 994;CS-617;Cl-994;Goe 5549;PD 123654;Tacedinaline;CI994, >=99%;N-Acetyldinaline;CI994 (Tacedinaline)
CBNumber
CB5855542
Molecular Formula
C15H15N3O2
Formula Weight
269.3
MOL File
112522-64-2.mol
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Tacedinaline Property

Melting point:
216.1 °C
Boiling point:
450.6±30.0 °C(Predicted)
Density 
1.322±0.06 g/cm3(Predicted)
RTECS 
CU8702023
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Soluble in DMSO
pka
13.15±0.70(Predicted)
form 
powder
color 
off-white
Sensitive 
Air Sensitive
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey
VAZAPHZUAVEOMC-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
HS Code 
2924.29.7790
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C0621
Product name
CI 994
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$128
Updated
2024/03/01
Sigma-Aldrich
Product number
C0621
Product name
CI 994
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$492
Updated
2024/03/01
TCI Chemical
Product number
A2501
Product name
4-Acetamido-N-(2-aminophenyl)benzamide
Purity
>98.0%(HPLC)
Packaging
10mg
Price
$66
Updated
2024/03/01
TCI Chemical
Product number
A2501
Product name
4-Acetamido-N-(2-aminophenyl)benzamide
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$225
Updated
2024/03/01
Alfa Aesar
Product number
J65561
Product name
CI 994
Packaging
25mg
Price
$108
Updated
2021/12/16
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Tacedinaline Chemical Properties,Usage,Production

Description

CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively.1 Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo.2,3 Increases neuroplasticity during memory extinction.4 Protects beta cells from cytokine-induced apoptosis.4

Uses

Tacedinaline is a histone deacetylase (HDAC) inhibitor. Tacedinaline is an anti-cancer agent as HDAC inhibitors block angiogenesis, arrest cell growth, and lead to differentiation and apoptosis in tumor cells. Studies show Tacedinaline to be effective against acute myeloid leukemia in vitro and in vivo when used in combination with conventional anti-cancer agents.

Definition

ChEBI: A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Al o used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.

Biological Activity

Orally active histone deacetylase (HDAC) inhibitor (K i values are 0.41, 0.75, >100 and >100 μ M for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G 1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo .

target

HDAC1

storage

+4°C

References

1) Moradei et al. (2007), Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity; J. Med. Chem., 50 5543 2) Beckers et al. (2007), Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group; Int. J. Cancer, 121 1138 3) Loprevite et al. (2005), In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines; Oncol. Res., 15 39 4) Chou et al. (2012), Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis; Chem. Biol., 19 669

Tacedinaline Preparation Products And Raw materials

Raw materials

Preparation Products

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Tacedinaline Suppliers

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View Lastest Price from Tacedinaline manufacturers

Career Henan Chemical Co
Product
Tacedinaline 112522-64-2
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

112522-64-2, TacedinalineRelated Search:

Benzamide p-Aminobenzamide Anthranilamide Acetaminophen Panobinostat PCI 34051 Mocetinostat (MGCD0103) Vorinostat Entinostat RGFP966 Dinalin N-{4-[(methylamino)methyl]phenyl}acetamide ACETAMINOPHENOL BP/USP Tacedinaline AURORA 8656 AURORA 8835

  • Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-
  • acetyldinaline
  • Tacedinaline
  • CI 994
  • N-Acetyldinaline
  • 4-AcetaMido-N-(2-aMinophenyl)benzaMide
  • Cl-994(Tacedinalin,N-Acetyldinalin)
  • CI994 (Tacedinaline)
  • CI-994 4-Acetylamino-N-(2'-aminophenyl)benzamide
  • Goe 5549
  • PD 123654
  • CI994, >=99%
  • CI 994 - PD 123654 | Tacedinaline
  • -aminophenyl)benzamide
  • PD-123654;CI-994;PD123654
  • CS-617
  • Cl-994
  • CI-994 (Acetyldinaline,PD123654)
  • 4-acetylamino-n-(2'-aminophenyl)benzamide
  • 4-Acetamido-N-(2-aminophenyl)benzamide &gt
  • Tacedinaline (CI994)
  • Tacedinaline USP/EP/BP
  • Tacedinaline (GOE-5549, PD-123654, CI-994
  • Goe5549,CI-994,Tacedinaline,inhibit,HDAC,CI 994,Inhibitor,Histone deacetylases,Apoptosis,Goe 5549
  • CI-994, HDAC inhibitor. Cell-permeable.
  • 112522-64-2
  • Inhibitors
  • Inhibitor
  • Apoptosis Inducers