pimagedine
- Product Name
- pimagedine
- CAS No.
- 79-17-4
- Chemical Name
- pimagedine
- Synonyms
- pimagedine;Aids030897;Aids-030897;Aminate base;1-Aminoguanidine;N-Aminoguanidine;Monoaminoguanidine;Aminoguanidine (ag);Ribavirin Impurity S;Aminoguanidine mordant
- CBNumber
- CB5875700
- Molecular Formula
- CH6N4
- Formula Weight
- 74.09
- MOL File
- 79-17-4.mol
pimagedine Property
- Melting point:
- 182-185 °C (decomp)
- Boiling point:
- 159.5±23.0 °C(Predicted)
- Density
- 1.72±0.1 g/cm3(Predicted)
- refractive index
- 1.6660 (estimate)
- pka
- 11.08±0.70(Predicted)
N-Bromosuccinimide Price
- Product number
- P445105
- Product name
- Pimagedinehydrochloride
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 18895
- Product name
- Pimagedine
- Purity
- 98%
- Packaging
- 5mg
- Price
- $950
- Updated
- 2021/12/16
- Product number
- INB0000371
- Product name
- AMINOGUANIDINE
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $1146.05
- Updated
- 2021/12/16
pimagedine Chemical Properties,Usage,Production
Chemical Properties
Aminoguanidine is prepared from hydrazine
and aqueous cyanamide solution. Processes
based on the reduction of nitroguanidine have
no industrial significance.
Chemical Properties
Aminoguanidine [CAS: 79-17-4], CH6N4, Mr 74.09, is a base that forms salts with both inorganic and organic acids. It is soluble in water and ethanol. Free aminoguanidine is stable for only a short time; therefore, it is marketed in the form of its stable salts. Commercially, aminoguanidine is offered as the bicarbonate salt [2582-30-1], a white powder of usually 99 % assay. The water solubility at room temperature is low (< 5 g/L). It is offered by most world-scale hydrazine producers (→Hydrazine). Other salts can be prepared from the bicarbonate by reaction with acid.
Uses
Inhibitor (advanced glycosylation end-product formation).
Definition
ChEBI: Aminoguanidine is a one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor and an EC 1.14.13.39 (nitric oxide synthase) inhibitor. It is a member of guanidines and a one-carbon compound.
Enzyme inhibitor
This substituted hydrazine (FWhydrochloride = 110.55 g/mol; CAS 79-17-4), also named pimagedine, is a strong inhibitor of diamine oxidases as well as nitric oxide synthase. Note that aminoguanidine also inhibits the formation of advanced glycosylation end-products, reportedly by reacting with and trapping Amadori rearrangement-derived fragmentation products in solution. In view of this property, aminoguanidine has often been used to treat complications associated with chronic diabetes. Target(s): amine oxidase (copper-containing), or diamine oxidase; methylamine dehydrogenase; tryptophan tryptophylquinone enzymes; nitric-oxide synthase; b-fructofuranosidase, or invertase; monoamine oxidase, or amine oxidase; histidine decarboxylase; aldose reductase; catalase; formation of advanced glycosylation end products; adenosylmethionine decarboxylase; arginine deaminase; arginine kinase; aspartate aminotransferase; histamine N-methyltransferase.
pimagedine Preparation Products And Raw materials
Raw materials
Preparation Products
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