ChemicalBook > CAS DataBase List > carbutamide

carbutamide

Product Name
carbutamide
CAS No.
339-43-5
Chemical Name
carbutamide
Synonyms
Emedan;U-6987;Oranil;Bucrol;Burcol;Nadisan;Invenol;Alentin;Bucarban;Bukarban
CBNumber
CB5883608
Molecular Formula
C11H17N3O3S
Formula Weight
271.34
MOL File
339-43-5.mol
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carbutamide Property

Melting point:
144-145°
Density 
1.2840 (rough estimate)
refractive index 
1.6630 (estimate)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
pKa 5.75(H2O t=25±0.02 I=0.2) (Uncertain)
color 
Off-White to Pale Beige
Water Solubility 
535.2mg/L(37 ºC)
EPA Substance Registry System
Benzenesulfonamide, 4-amino-N-[(butylamino)carbonyl]- (339-43-5)
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Safety

Hazardous Substances Data
339-43-5(Hazardous Substances Data)
Toxicity
LD50 s.c. in mice: 3 g/kg (Haack, Hagedorn)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S385433
Product name
N1-(BUTYLCARBAMOYL)-SULFANILAMIDE
Purity
Aldrich
Packaging
50mg
Price
$209
Updated
2024/03/01
TRC
Product number
C183300
Product name
Carbutamide
Packaging
5mg
Price
$80
Updated
2021/12/16
TRC
Product number
C183300
Product name
Carbutamide
Packaging
25mg
Price
$120
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC19809
Product name
Carbutamide
Packaging
25mg
Price
$160
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC19809
Product name
Carbutamide
Packaging
10mg
Price
$86
Updated
2021/12/16
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carbutamide Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Peach Solid

Originator

Carbutamide,Servier

Uses

Antidiabetic.

Definition

ChEBI: Carbutamide is a sulfonamide and a member of benzenes.

Manufacturing Process

223 g of the sodium salt of acetylsulfaniamide are stirred with 223 ml of triethylene glycol. 118 g of n-butyl isothiocyanate are added to the resulting homogeneous mixture. The resulting syrup is heated to 85°C for 4 hours. The mixture is then stirred with 1000 ml of chloroform and 1000 ml of water. The chloroform layer is twice shaken with water, each time with 250 ml. The aqueous extracts are combined and rendered weakly alkaline to phenolphthalein by addition of hydrochloric acid. Unreacted acetyl sulfanilamide precipitates and filtered off. The filtrate is acidified to a pH of 6.5 by the addition of HCl. An oily precipitate settles from the reaction solution and is separated therefrom. N-Butyl acetyl sulfanilylthiourea is precipitated from mother liquors obtained thereby by addition of HCl until Congo paper changes its color to blue. 210 g N-butyl acetyl sulfanilylthiourea are dissolved in 1400 ml of acetone while heating. The solution is mixed with 500 ml of water. A solution of 63 g of sodium nitrite in 120 ml of water is added thereto within about 45 minutes while stirring and cooling to 15°-20°C.
A suspension of crystals is obtained. 240 ml of 25% glacial acid are added thereto within 30 minutes. Stirring of the mixture is continued for 6 hours. N-Butyl acetyl sulfanilylurea mixed with sulfur is precipitated and filtered off. The crude reaction product is suspended in 1000 ml of water and is rendered weakly alkaline to phenolphthalein. Undissolved sulfur is filtered off. The filtrate is acidified by the addition of HCl. 250 g of N-butyl acetyl sulfanilylthiourea having a melting point of 186°-189°C are obtained. It is heated with 500 ml of 5 N potassium hydroxide solution to a temperature of 92°C for 2 hours while stirring. The solid reaction product is dissolved by heating with 750 ml of water and is purified by means of activated charcoal. The resulting solution is heated to 60°C and acidified by addition of HCl. 187 g of N-butyl acetyl sulfanilylthiourea melting at 139°-141°C obtained thereby.

Therapeutic Function

Oral hypoglycemic

Safety Profile

A poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NO, and SOx.

carbutamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from carbutamide manufacturers

Career Henan Chemical Co
Product
carbutamide 339-43-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31

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