viomycin

Product Name: viomycin
CAS No.: 32988-50-4
Chemical Name: viomycin
Synonyms: Viocin;viomycin;Vioactane;Coliomycin;FLORIMYCIN;Vinacetin A;Tuberactinomycin B;viomycin USP/EP/BP;Glycine, 3-amino-N-[(3S)-3,6-diamino-1-oxohexyl]-L-alanyl-L-seryl-L-seryl-(2Z)-3-[(aminocarbonyl)amino]-2,3-didehydroalanyl-2-[(4R,6S)-2-amino-1,4,5,6-tetrahydro-6-hydroxy-4-pyrimidinyl]-, (5→13)-lactam, (2S)-;(S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamidedisulfate
CBNumber: CB5910382
Molecular Formula: C25H43N13O10
Formula Weight: 685.7
MOL File: 32988-50-4.mol

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viomycin Property

Melting point:: 280 °C
Boiling point:: 695.81°C (rough estimate)
Density: 1.3613 (rough estimate)
refractive index: 1.6700 (estimate)
storage temp.: Store at -20°C
solubility: Water (Slightly)
form: Powder
pka: pKa 8.2 (Uncertain);10.3 (Uncertain)
Water Solubility: Soluble to 75 mM in water
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 3787
Product name: Viomycin
Packaging: 10
Price: $182
Updated: 2021/12/16

ApexBio Technology

Product number: A8645
Product name: Viomycin
Packaging: 10mg
Price: $274
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009965
Product name: VIOMYCIN
Purity: 95.00%
Packaging: 5MG
Price: $500.54
Updated: 2021/12/16

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viomycin Chemical Properties,Usage,Production

Description

Viomycin was found independently in 1951, in the culture broth of Streptomyces puniceus by Pfizer Research Laboratories and in that of S. floridae by Parke Davis Co. It shows strong activity against Mycobacterium species and moderate activity against gram-positive and gram-negative bacteria. Viomycin has been used by intramuscular administration to treat tuberculosis, but because of its ototoxicity and renal toxicity it is being replaced by more active and less toxic drugs, such as enviomycin and other antituberculotic antibiotics.

Originator

Vinactane,Ciba,US ,1953

Uses

Viomycin is a basic peptide antibiotic, which is an effective agent against multidrug-resistant tuberculosis.

Definition

ChEBI: A cyclic peptide antibiotic produced by the actinomycete Streptomyces puniceus, used in the treatment of tuberculosis.

Indications

Viomycin is a complex polypeptide antibiotic that is active against MDR strains of tuberculosis. Cross-resistance between viomycin and kanamycin is less frequent than between viomycin and capreomycin.

Manufacturing Process

Viomycin is produced by inoculating a nutrient medium with a viable strain of the organism Actinomyces vinaceus. A method for the production of viomycin is set forth in US Patent 2,663,445 comprising inoculating a medium containing soy peptone, beef extract, dextrose, sodium chloride and a silicone antifoaming agent with a spore suspension of Actinomyces vinaceus and incubating the inoculated medium for 120 hours at a temperature of 26°C while passing sterile air through the medium at a rate of 500 ml per liter of medium per minute.

brand name

Viocin Sulfate (Pfizer).

Therapeutic Function

Antitubercular

Biological Activity

Member of the tuberactinomycin family of antibiotics . Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans -cleavage of the Neurospora VS ribozyme.

viomycin Preparation Products And Raw materials

Raw materials

Preparation Products

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viomycin Suppliers

CHINA 9 United Kingdom 1 United States 5 Global 15

3B Pharmachem (Wuhan) International Co.,Ltd.

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Shaanxi Dideu Medichem Co. Ltd

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MedBioPharmaceutical Technology Inc

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Email: order@med-bio.cn
Country: China
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Shaanxi Dideu Newmaterial Co., Ltd.

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Shaanxi Cuikang Pharmaceutical Technology Co., Ltd

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Shanghai Weiwei Biological Technology Co., Ltd.

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Shanghai Chaoyan Biotechnology Co., Ltd.

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Lanospharma Laboratories Co.,Ltd

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Shanghai New Union Textra Import & Export Co., Ltd

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32988-50-4, viomycinRelated Search:

Pterostilbene BUTEIN Sisomicin CAPREOMYCIN viomycin tuberactinomycin-O

viomycin

FLORIMYCIN

Coliomycin

Tuberactinomycin B

Vinacetin A

Vioactane

Viocin

(S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamidedisulfate

Glycine, 3-amino-N-[(3S)-3,6-diamino-1-oxohexyl]-L-alanyl-L-seryl-L-seryl-(2Z)-3-[(aminocarbonyl)amino]-2,3-didehydroalanyl-2-[(4R,6S)-2-amino-1,4,5,6-tetrahydro-6-hydroxy-4-pyrimidinyl]-, (5→13)-lactam, (2S)-

viomycin USP/EP/BP

32988-50-4

C25H43N13O10

C25H43N13O102H2SO4