Synthesis
ChemicalBook > CAS DataBase List > 1H-indole-3-propylamine

1H-indole-3-propylamine

Synthesis
Product Name
1H-indole-3-propylamine
CAS No.
6245-89-2
Chemical Name
1H-indole-3-propylamine
Synonyms
Einecs 228-361-1;1H-indole-3-propylamine;1H-Indole-3-propanamine;N-propyl-1H-indol-3-amine;1H-Indole-3-propan-1-amine;(1H-Indol-3-yl)-1-propanamine
CBNumber
CB5927122
Molecular Formula
C11H14N2
Formula Weight
174.24
MOL File
6245-89-2.mol
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1H-indole-3-propylamine Property

Melting point:
64 °C
Boiling point:
353.7±25.0 °C(Predicted)
Density 
1.125±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
17.29±0.30(Predicted)
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Safety

Risk Statements 
20/21/22-37/38-48
Safety Statements 
22-26-7/8-36/37/39-45
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
I633913
Product name
3-(Indol-3-yl)propanamine
Packaging
50mg
Price
$95
Updated
2021/12/16
TRC
Product number
I633913
Product name
3-(Indol-3-yl)propanamine
Packaging
250mg
Price
$250
Updated
2021/12/16
AK Scientific
Product number
J55003
Product name
(1H-Indol-3-yl)-1-propanamine
Packaging
1g
Price
$135
Updated
2021/12/16
Matrix Scientific
Product number
072031
Product name
(1H-Indol-3-yl)-1-propanamine
Purity
95+%
Packaging
1g
Price
$440
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0074502
Product name
3-(1H-INDOL-3-YL)-1-PROPANAMINE
Purity
95.00%
Packaging
1G
Price
$925.31
Updated
2021/12/16
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1H-indole-3-propylamine Chemical Properties,Usage,Production

Synthesis

A solution of LAH (1.0 M in ether, 36.5 mL, 36.5 mmol) was cooled to 0 °C, and  a solution of the cyanoethyl indole (2.78 g, 16.3 mmol) was added slowly. Then, the solution was heated at reflflux for 3 h. It was cooled to 0 °C and quenched by dropwise addition of water (20 mL) followed by 1 N sodium hydroxide (40 mL). The phases were separated, and the aqueous phase was extracted with ether. The combined organic phases were washed with brine and then dried (potassium hydroxide). Evaporation of the solvent gave 2.6 g (92%) of homotryptamine as a yellow oil, which solidifified on standing. The hydrochloride was prepared by dissolving the amine in a minimum of ethanol and then a saturated solution of hydrogen chloride in ether was added until no additional salt formation was observed. The hydrochloride was recrystallized from ethanol.

Reference: Kuehne, M. E.; Cowen, S. D.; Xu, F.; Borman, L. S. J. Org. Chem. 2001, 66, 5303–5316.

Chemical Properties

Light yellow powder

1H-indole-3-propylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-indole-3-propylamine Suppliers

Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52925
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80