ChemicalBook > CAS DataBase List > (R)-(+)-9-(2-Hydroxypropyl)adenine

(R)-(+)-9-(2-Hydroxypropyl)adenine

Product Name
(R)-(+)-9-(2-Hydroxypropyl)adenine
CAS No.
14047-28-0
Chemical Name
(R)-(+)-9-(2-Hydroxypropyl)adenine
Synonyms
Tenofovir Impurity 91;(R)-9-(2-HydroxypropyL;Tenofovir alafenamide-30;Tenofovir Impurity 1 CRS;Intermediate of Tenofovir;MJZYTEBKXLVLMY-RXMQYKEDSA-N;Tenofovir Related Compound 11;(R)-9-(2-Hydroxypropyl)ademine;Tenofovir (R)-Propanol Impurity;9-[(2R)-2-Hydroxypropyl]adenine
CBNumber
CB5946929
Molecular Formula
C8H11N5O
Formula Weight
193.21
MOL File
14047-28-0.mol
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(R)-(+)-9-(2-Hydroxypropyl)adenine Property

Melting point:
193 °C
Boiling point:
457.7±55.0 °C(Predicted)
Density 
1.57
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
14.42±0.20(Predicted)
color 
White to Off-White
InChI
InChI=1/C8H11N5O/c1-5(14)2-13-4-12-6-7(9)10-3-11-8(6)13/h3-5,14H,2H2,1H3,(H2,9,10,11)/t5-/s3
InChIKey
MJZYTEBKXLVLMY-GQMHJJTINA-N
SMILES
N1(C[C@@H](C)O)C=NC2C(=NC=NC1=2)N |&1:2,r|
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Safety

HS Code 
2933.99.8290
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
H1291
Product name
(R)-9-(2-Hydroxypropyl)adenine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$26
Updated
2025/07/31
TCI Chemical
Product number
H1291
Product name
(R)-9-(2-Hydroxypropyl)adenine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$36
Updated
2025/07/31
TRC
Product number
H952560
Product name
(R)-9-[2-(Hydroxypropyl]Adenine(DesphosphorylTenofovir)
Packaging
1g
Price
$185
Updated
2021/12/16
AK Scientific
Product number
J95610
Product name
(R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol
Packaging
5g
Price
$30
Updated
2021/12/16
AK Scientific
Product number
J95610
Product name
(R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol
Packaging
100g
Price
$180
Updated
2021/12/16
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(R)-(+)-9-(2-Hydroxypropyl)adenine Chemical Properties,Usage,Production

Chemical Properties

white powde

Uses

(R)-9-[2-(Hydroxypropyl] Adenine (Desphosphoryl Tenofovir) (cas# 14047-28-0) is a useful reagent for preparing the antiviral drug tenofovir.

Synthesis

66224-66-6

16606-55-6

14047-28-0

To a reaction flask was added 200 mL of N,N-dimethylformamide (DMF) protected by N2, adenine (30.0 g, 0.222 mol, 1 equiv) and stirred. NaOH (0.45 g, 0.011 mol) and R-propylene carbonate (28.5 g, 0.279 mol, 1.26 eq.) were subsequently added. The reaction mixture was warmed to 130-140 °C within 12 h of the sampling test, and the reaction was stopped when the adenine content dropped to 1% or less. Slowly cooled to below 90°C, 200 mL of toluene was added, cooling was continued to 0-5°C, and the mixture was stirred for 2 hours. Filtered and dried to give 38.13 g white solid in 87% yield.

References

[1] Patent: CN103848869, 2016, B. Location in patent: Paragraph 0053; 0054
[2] Patent: CN103848868, 2017, B. Location in patent: Paragraph 0055; 0058; 0059
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 26, p. 7799 - 7806
[4] Patent: WO2008/56264, 2008, A2. Location in patent: Page/Page column 69-70; 75; 81
[5] Patent: WO2015/51874, 2015, A1. Location in patent: Page/Page column 6; 20; 21

(R)-(+)-9-(2-Hydroxypropyl)adenine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-(+)-9-(2-Hydroxypropyl)adenine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
(R)-(+)-9-(2-Hydroxypropyl)adenine 14047-28-0
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
500kgs
Release date
2021-09-16
Henan Aochuang Chemical Co.,Ltd.
Product
(R)-(+)-9-(2-Hydroxypropyl)adenine 14047-28-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Tenofovir impurity 62 14047-28-0
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
5g
Release date
2025-02-13

14047-28-0, (R)-(+)-9-(2-Hydroxypropyl)adenineRelated Search:

Hydroxypropyl cellulose 6-Benzylaminopurine Tribenuron methyl Ethanol Hydroxypropyl methyl cellulose 2-Hydroxypropyl-β-cyclodextrin METSULFURON METHYL 3-METHYLADENINE Starch, hydrogen phosphate, 2-hydroxypropyl ether Hydroxypropyl starch Methyl salicylate Ethyl acetate Adenine Purine Kresoxim-methyl N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine Thiophanate-methyl isopropyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate

  • R-9-(2-hydroxypropyl) adenine, 9-HPA
  • (R)-(+)-9-(2-HYDROXYPROPYL)ADENINE,98%
  • (R)-(+)-9-(2-Hydroxypropyl)adenine
  • 6-Amino-alpha-methyl-9H-purine-9-ethanol
  • Tenofovir (R)-Propanol Impurity
  • D-(-)-9-(2-Hydroxypropyl)adenine
  • (R)-9-[2-(Hydroxypropyl] Adenine (Desphosphoryl Tenofovir)
  • (R)-6-aMino-alpha-Methyl-9H-purine-9-ethanol
  • (R)-9-(2-Hydroxypropyl)ademine
  • (R)-6-aMino-alpha-Methyl-9H-purine-9-ethanol (HPA)
  • (αR)-6-AMino-α-Methyl-9H-purine-9-ethanol
  • (R)-9-(2-hydroxypropyl) adenine (SC)
  • (R)-(+)-9-(2-Hydroxypropyl)adenine (HPA)
  • 9-[(2R)-2-Hydroxypropyl]adenine
  • (R)-(+)-9-(2-Hydroxypropyl)adenine(PMP)
  • (2R)-1-(6-aMino-9H-purin-9-yl)propan-2-ol
  • (R)-1-(6-AMino-purin-9-yl)-propan-2-ol
  • 9H-Purine-9-ethanol,6-amino-a-methyl-, (aR)-
  • (2R)-1-(6-Aminopurin-9-yl)propan-2-ol
  • Tenofovir disoproxil Impurity 24
  • (<i>R</i>)-9-(2-Hydroxypropyl)adenine
  • MJZYTEBKXLVLMY-RXMQYKEDSA-N
  • Tenofovir alafenamide-30
  • Tenofovir Related Compound 11
  • Tenofovir Impurity 91
  • Intermediate of Tenofovir
  • (R)-9-(2-Hydroxypropyl)adenine &gt
  • (R)-9-(2-HydroxypropyL
  • (R)-6-Amino-9-(2-hydroxypropyl)purine
  • (R)-(+)-9-(2-Hydroxypropyl)adenine USP/EP/BP
  • (R) - (+) -9- (2-Hydroxypropyl) Adenine / (R) -9- (2-Hydroxypropyl) Adenine
  • 9H-Purine-9-ethanol, 6-amino-α-methyl-, (αR)-
  • R-9-(2-Hydroxy Propyl)adenineQ: What is R-9-(2-Hydroxy Propyl)adenine Q: What is the CAS Number of R-9-(2-Hydroxy Propyl)adenine Q: What is the storage condition of R-9-(2-Hydroxy Propyl)adenine
  • (R)-1-(6-amino-1H-purin-1-yl)propan-2-ol
  • Tenofovir Impurity 1 CRS
  • (R)-9-[2-(Hydroxypropyl] Adenine, CAS 14047-28-0
  • 14047-28-0
  • Tenofovir
  • Chiral Reagents
  • Bases & Related Reagents
  • Nucleotides