tert-Butyl 4-bromo-2-nitrobenzoate
Uses- Product Name
- tert-Butyl 4-bromo-2-nitrobenzoate
- CAS No.
- 890315-72-7
- Chemical Name
- tert-Butyl 4-bromo-2-nitrobenzoate
- Synonyms
- t-Butyl 4-bromo-2-nitrobenzoate;tert-Butyl 4-bromo-2-nitrobenzoate;tert-Butyl4-bromo-2-nitrobenzoate98%;tert-Butyl 4-bromo-2-nitrobenzoate 98%;Benzoic acid, 4-bromo-2-nitro-, 1,1-dimethylethyl ester
- CBNumber
- CB5956371
- Molecular Formula
- C11H12BrNO4
- Formula Weight
- 302.12
- MOL File
- 890315-72-7.mol
tert-Butyl 4-bromo-2-nitrobenzoate Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light yellow to yellow Solid
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B694133
- Product name
- t-Butyl4-bromo-2-nitrobenzoate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B694133
- Product name
- t-Butyl4-bromo-2-nitrobenzoate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B694133
- Product name
- t-Butyl4-bromo-2-nitrobenzoate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 4654-9-Y9
- Product name
- tert-Butyl 4-bromo-2-nitrobenzoate
- Purity
- 98%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 4654-9-Y9
- Product name
- tert-Butyl 4-bromo-2-nitrobenzoate
- Purity
- 98%
- Packaging
- 5G
- Price
- $61
- Updated
- 2021/12/16
tert-Butyl 4-bromo-2-nitrobenzoate Chemical Properties,Usage,Production
Uses
4-Bromo-2-nitrobenzoate tert-butyl ester can be used as a pharmaceutical synthesis intermediate. It can be prepared by reacting 4-bromo-2-nitrobenzoic acid with 2-bromo-2-methylpropane. It can be used to prepare the compound 2-amino-4-bromobenzoate tert-butyl ester, which can also be widely used as a pharmaceutical synthesis intermediate.
Synthesis
To a solution containing 5.0 g of 4-bromo-2-nitrobenzoic acid 50 mL of N,N-dimethylacetamide was added 41 g of potassium carbonate, 4.6 g of benzyltriethylammonium chloride, and 69 mL of 2-bromo-2-methylpropane and stirred at 55 C for 10 hours. After the reaction mixture was cooled to room temperature, 12 mL of 2-bromo-2-methylpropane was added and stirred at 55C for 4 hours. After cooling the reaction mixture to room temperature, water and ethyl acetate were added. The organic layer was separated and washed with 10% aqueous citric acid and saturated aqueous sodium chloride in turn, then dried with anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. Methanol was added to the obtained residue and 3.0 g of tert-butyl 4-bromo-2-nitrobenzoate was obtained as a white solid by filtration and separation of solids.1H-NMR (CDCl3) : 1.55 (9H, s), 7.63 (1H, d, J = 8.3 Hz), 7.77 (1H, dd, J = 8.3, 1.9 Hz), 7.95 (1H, d , J = 1.9 Hz).
tert-Butyl 4-bromo-2-nitrobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-Butyl 4-bromo-2-nitrobenzoate Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44802
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19906
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- 13912302692 13912302692;
- Fax
- 0519-88064678
- sales@anxuanchem.com
- Country
- China
- ProdList
- 4824
- Advantage
- 58
- Tel
- 028-64353063
- Fax
- 028-64353063 QQ:784253935
- reacchemical@163.com
- Country
- China
- ProdList
- 5253
- Advantage
- 58