ChemicalBook > CAS DataBase List > 4-hydroxy-2-Piperidinone

4-hydroxy-2-Piperidinone

Product Name: 4-hydroxy-2-Piperidinone
CAS No.: 476014-76-3
Chemical Name: 4-hydroxy-2-Piperidinone
Synonyms: 4-hydroxy-2-Piperidi;4-Hydroxy-2-piperidone;4-hydroxy-2-Piperidinone;4-Hydroxy-piperidin-2-one;2-Piperidinone, 4-hydroxy-;2-Piperidinone, 4-hydroxy- 95%min
CBNumber: CB5958436
Molecular Formula: C5H9NO2
Formula Weight: 115.13
MOL File: 476014-76-3.mol

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4-hydroxy-2-Piperidinone Property

Melting point:: 165-168°C
Boiling point:: 352.3±35.0 °C(Predicted)
Density: 1.199±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Methanol (Slightly, Sonicated)
pka: 14.01±0.20(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1S/C5H9NO2/c7-4-1-2-6-5(8)3-4/h4,7H,1-3H2,(H,6,8)
InChIKey: PRCAKTIAKXMBQF-UHFFFAOYSA-N
SMILES: N1CCC(O)CC1=O

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-41
Safety Statements: 26-39

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H950875
Product name: 4-Hydroxy-2-piperidinone
Packaging: 250mg
Price: $150
Updated: 2021/12/16

TRC

Product number: H950875
Product name: 4-Hydroxy-2-piperidinone
Packaging: 2.5g
Price: $1190
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0025883
Product name: 4-HYDROXY-2-PIPERIDINONE
Purity: 95.00%
Packaging: 5G
Price: $1212.75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0025883
Product name: 4-HYDROXY-2-PIPERIDINONE
Purity: 95.00%
Packaging: 10G
Price: $1720.95
Updated: 2021/12/16

Matrix Scientific

Product number: 118927
Product name: 4-Hydroxy-2-piperidinone
Purity: 95+%
Packaging: 5g
Price: $1764
Updated: 2021/12/16

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4-hydroxy-2-Piperidinone Chemical Properties,Usage,Production

Uses

4-Hydroxy-2-piperidinone is a synthetic intermediate in the synthesis of pharmaceutical goods.

Synthesis

50607-30-2

476014-76-3

Step 1) NaBH4 (1 g, 26.55 mmol) was slowly added to a solution of piperidine-2,4-dione (1 g, 8.8 mmol) in methanol (25 mL) at 0°C. The reaction mixture was stirred at room temperature overnight before the solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol, 5:1, v/v) to afford 4-hydroxy-2-piperidone as a yellow solid (960 mg, 87% yield). m/z by LC-MS (ESI, positive ion mode): 138 [M + Na]+.

References

[1] Patent: WO2013/138210, 2013, A1. Location in patent: Paragraph 0258
[2] Patent: EP2947085, 2015, A1. Location in patent: Paragraph 0238; 0239; 0240

4-hydroxy-2-Piperidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-hydroxy-2-Piperidinone manufacturers

Career Henan Chemical Co

Product: 4-hydroxy-2-Piperidinone 476014-76-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-21

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4-hydroxy-2-Piperidinone

4-Hydroxy-piperidin-2-one

2-Piperidinone, 4-hydroxy-

4-hydroxy-2-Piperidi

4-Hydroxy-2-piperidone

2-Piperidinone, 4-hydroxy- 95%min

476014-76-3