4-hydroxy-2-Piperidinone
- Product Name
- 4-hydroxy-2-Piperidinone
- CAS No.
- 476014-76-3
- Chemical Name
- 4-hydroxy-2-Piperidinone
- Synonyms
- 4-hydroxy-2-Piperidi;4-Hydroxy-2-piperidone;4-hydroxy-2-Piperidinone;4-Hydroxy-piperidin-2-one;2-Piperidinone, 4-hydroxy-;2-Piperidinone, 4-hydroxy- 95%min
- CBNumber
- CB5958436
- Molecular Formula
- C5H9NO2
- Formula Weight
- 115.13
- MOL File
- 476014-76-3.mol
4-hydroxy-2-Piperidinone Property
- Melting point:
- 165-168°C
- Boiling point:
- 352.3±35.0 °C(Predicted)
- Density
- 1.199±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Methanol (Slightly, Sonicated)
- pka
- 14.01±0.20(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C5H9NO2/c7-4-1-2-6-5(8)3-4/h4,7H,1-3H2,(H,6,8)
- InChIKey
- PRCAKTIAKXMBQF-UHFFFAOYSA-N
- SMILES
- N1CCC(O)CC1=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H950875
- Product name
- 4-Hydroxy-2-piperidinone
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- H950875
- Product name
- 4-Hydroxy-2-piperidinone
- Packaging
- 2.5g
- Price
- $1190
- Updated
- 2021/12/16
- Product number
- CHM0025883
- Product name
- 4-HYDROXY-2-PIPERIDINONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1212.75
- Updated
- 2021/12/16
- Product number
- CHM0025883
- Product name
- 4-HYDROXY-2-PIPERIDINONE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1720.95
- Updated
- 2021/12/16
- Product number
- 118927
- Product name
- 4-Hydroxy-2-piperidinone
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1764
- Updated
- 2021/12/16
4-hydroxy-2-Piperidinone Chemical Properties,Usage,Production
Uses
4-Hydroxy-2-piperidinone is a synthetic intermediate in the synthesis of pharmaceutical goods.
Synthesis
50607-30-2
476014-76-3
Step 1) NaBH4 (1 g, 26.55 mmol) was slowly added to a solution of piperidine-2,4-dione (1 g, 8.8 mmol) in methanol (25 mL) at 0°C. The reaction mixture was stirred at room temperature overnight before the solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol, 5:1, v/v) to afford 4-hydroxy-2-piperidone as a yellow solid (960 mg, 87% yield). m/z by LC-MS (ESI, positive ion mode): 138 [M + Na]+.
References
[1] Patent: WO2013/138210, 2013, A1. Location in patent: Paragraph 0258
[2] Patent: EP2947085, 2015, A1. Location in patent: Paragraph 0238; 0239; 0240
4-hydroxy-2-Piperidinone Preparation Products And Raw materials
Raw materials
Preparation Products
4-hydroxy-2-Piperidinone Suppliers
- Tel
- --
- Fax
- --
- info@chemsworth.com
- Country
- India
- ProdList
- 6700
- Advantage
- 30
- Tel
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- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 4-hydroxy-2-Piperidinone manufacturers
- Product
- 4-hydroxy-2-Piperidinone 476014-76-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-21