AG 957

Product Name: AG 957
CAS No.: 140674-76-6
Chemical Name: AG 957
Synonyms: AG 957;NSC 654705;TYRPHOSTIN 957;TYRPHOSTIN AG 957;LAVENDUSTIN C ANALOG;AG957, 10 mM in DMSO;Methyl 4-((2,5-dihydroxybenzyl)amino)benzoate;4-AMINO-N-(2,5-DIHYDROXYBENZYL)METHYL BENZOATE;Tyrphostin AG 957, p210 tyrosine kinase inhibitor;METHYL-4-[N-(2',5'-DIHYDROXYBENZYL)AMINO]BENZOATE
CBNumber: CB6100142
Molecular Formula: C15H15NO4
Formula Weight: 273.28
MOL File: Mol file

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AG 957 Property

Boiling point:: 504.2±45.0 °C(Predicted)
Density: 1.337±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMSO: soluble
form: crystalline solid
pka: 10.30±0.43(Predicted)
color: Off-white to light brown

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17259
Product name: AG957
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 17259
Product name: AG957
Purity: ≥95%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 17259
Product name: AG957
Purity: ≥95%
Packaging: 10mg
Price: $213
Updated: 2024/03/01

TRC

Product number: T947970
Product name: TyrphostinAG957
Packaging: 1mg
Price: $40
Updated: 2021/12/16

ApexBio Technology

Product number: C5826
Product name: AG957
Packaging: 5mg
Price: $124
Updated: 2021/12/16

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AG 957 Chemical Properties,Usage,Production

Description

Tyrphostins are tyrosine phosphorylation inhibitors that act by inhibiting tyrosine kinases. AG957 is a tyrphostin that targets transforming Bcr-Abl fusion proteins (p185^Bcr-Abl, p210^Bcr-Abl), as well as normal c-Abl (IC₅₀s = 4.3, 1, and 7.1 μM, respectively, for human proteins). It also inhibits epidermal growth factor receptor (IC₅₀ = 0.25 μM). As the constitutively-active 210 kDa Bcr-Abl fusion protein commonly occurs in chronic myelogenous leukemia (CML) cells, AG957 is commonly used to study Bcr-Abl signaling in the CML K562 cell line. AG957 is also used to study signaling through c-Abl.

Uses

Tyrphostin AG 957 is a potent tyrosine kinase inhibitor. Also, it causes metabolic alterations in K562 cells. It is a COVID19-related research product.

Definition

ChEBI: 4-[(2,5-dihydroxyphenyl)methylamino]benzoic acid methyl ester is an aromatic amine.

in vivo

AG957 (10 mg/kg; intratracheally 1 h before intratracheal LPS challenge) blocks c-Abl activity in the lung of mice^[4].

Animal Model:	C57BL/6J mice^[4]
Dosage:	10 mg/kg
Administration:	Intratracheally 1 h before intratracheal LPS challenge
Result:	LPS induced significant phosphorylation of paxillin at Y31 and Y118. Inhibition of c-Abl by AG957 attenuated LPS-induced phosphorylation of paxillin at both sites. LPS induced significant phosphorylation of VE-cadherin in DMSO-treated mice, which was attenuated in AG957-treated mice.

References

[1]. anafi m, gazit a, gilon c, et al. selective interactions of transforming and normal abl proteins with atp, tyrosine-copolymer substrates, and tyrphostins. j biol chem. 1992 mar 5;267(7):4518-23.
[2]. kaur g, gazit a, levitzki a, et al. tyrphostin induced growth inhibition: correlation with effect on p210bcr-abl autokinase activity in k562 chronic myelogenous leukemia. anticancer drugs. 1994 apr;5(2):213-22.
[3]. jamieson l, carpenter l, biden tj, et al. protein kinase ciota activity is necessary for bcr-abl-mediated resistance to drug-induced apoptosis. j biol chem. 1999 feb 12;274(7):3927-30.
[4]. fu p, usatyuk pv, lele a, et al. c-abl mediated tyrosine phosphorylation of paxillin regulates lps-induced endothelial dysfunction and lung injury. am j physiol lung cell mol physiol. 2015 may 15;308(10):l1025-38.

AG 957 Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 957 Suppliers

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140674-76-6, AG 957Related Search:

TYRPHOSTIN AG 879 TYRPHOSTIN AG 1296 TYRPHOSTIN B56 TYRPHOSTIN AG 1024 LAVENDUSTIN C

METHYL-4-[N-(2',5'-DIHYDROXYBENZYL)AMINO]BENZOATE

LAVENDUSTIN C ANALOG

4-AMINO-N-(2,5-DIHYDROXYBENZYL)METHYL BENZOATE

AG 957

TYRPHOSTIN AG 957

TYRPHOSTIN 957

NSC 654705

Lavendustin C Analog, Methyl-4-[N-(2μ,5μ-dihydroxybenzyl)amino]benzoate

Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, methyl ester

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Tyrphostin AG 957, p210 tyrosine kinase inhibitor

AG957, 10 mM in DMSO

Methyl 4-((2,5-dihydroxybenzyl)amino)benzoate

140674-76-6

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Kinase/Phosphatase Biology

Receptor Tyrosine Kinase Inhibitors

Tyrosine Kinase (TK)