Weight loss drugs Drug Interactions safety Uses
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LORCASERIN

Weight loss drugs Drug Interactions safety Uses
Product Name
LORCASERIN
CAS No.
616202-92-7
Chemical Name
LORCASERIN
Synonyms
Apd356;Ar-10a;Apd-356;Apd 356;CS-1994;LORCASERIN;LORCASERIN API;Unii-637E494o0z;Lorcaserin powder;Lorcaserin-[13C6]
CBNumber
CB61011744
Molecular Formula
C11H14ClN
Formula Weight
195.69
MOL File
616202-92-7.mol
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LORCASERIN Property

Boiling point:
288 ºC
Density 
1.075
Flash point:
128 ºC
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Light Beige to Beige Semi-Solid
pka
9.99±0.40(Predicted)
Stability:
Hygroscopic
InChI
InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1
InChIKey
XTTZERNUQAFMOF-QMMMGPOBSA-N
SMILES
N1CCC2=CC=C(Cl)C=C2[C@@H](C)C1
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Safety

Hazardous Substances Data
616202-92-7(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological
Product number
281284
Product name
Lorcaserin
Packaging
50mg
Price
$335
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0005054
Product name
LORCASERIN
Purity
95.00%
Packaging
10MG
Price
$750.75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FL24938
Product name
Lorcaserin
Packaging
10mg
Price
$85
Updated
2021/12/16
Biosynth Carbosynth
Product number
FL24938
Product name
Lorcaserin
Packaging
50mg
Price
$225
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0005054
Product name
LORCASERIN
Purity
95.00%
Packaging
100MG
Price
$1963.5
Updated
2021/12/16
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LORCASERIN Chemical Properties,Usage,Production

Weight loss drugs

Lorcaserin is a new drug for the treatment of obesity , belonging to oral potent selective serotonin 2C receptor agonists, lorcaserin hydrochloride is successfully developed by the US company Arena, on June 27, 2012 by the US FDA it is approved for marketing, as adjuvant therapy for obesity or merge with at least one weight-related complications in overweight adults in low-calorie diet and exercise basis . Clinical studies show that the drug can reduce weight of obesity and overweight patients ,it can improve obesity-related metabolic parameters, and it is well tolerated. Lorcaserin affinity for the 5-HT2c 100 times higher than the 5-HT2B (valvular heart disease risk) ,it has good safety,it is the first FDA-approved weight-loss drug after 1999 . In a year of Lorcaserin treatment, the average weight loss ranges from 3 to 3.7 percent.

Drug Interactions

Due to the theoretical possibility of the mechanism of lorcaserin and serotonin syndrome, when lorcaserin is used in combination with the serotonergic neurotransmitter system drugs, extreme caution should be paid, including triptans monoamine oxidase inhibitor agent selective serotonin reuptake inhibitor selective serotonin and norepinephrine reuptake inhibitors, tricyclic antidepressants bupropion dextromethorphan, lithium tramadol and St. John's wort , etc. In addition, when the present product with CYP2D6 substrates when combined with the need to be cautious, because the product can increase the exposure of these drugs.
The above information is edited by the Chemicalbook of Tian Ye.

safety

Lorcaserin has good tolerability and safety, lorcaserin is used in non-diabetic patients, the most common adverse reactions are headache, dizziness, fatigue, nausea, dry mouth and constipation. This product is used in patients with diabetes, common adverse reactions are headache, back pain, cough, low blood sugar and fatigue.studies have found that lorcaserin and placebo are Similar in the proportion of serious adverse reactions, lorcaserin does not increase the incidence of valvular heart disease. After lorcaserin treatment , the incidence of depression is lower , the research shows that the proportion of depression led by lorcaserin 10mgbid, 10mgqd and placebo are 1.9%, 1.1% and 1.8%, emotional low incidence rates are 0.6%, 0.9% and 0.9%, the proportion of suicidal thoughts are 0.9%, 0.6% and 0.7% .the product is pregnancy X-class , pregnant women are disabled; whether this product is secreted by milk is unknown, breast-feeding women need to weigh on the use of the drug; this product is not recommended for children.

Uses

diet pills. Lorcaserin was used to treat Opioid Use Disorder (OUD).

Chemical Properties

Yellow Oil

Uses

Lorcaserin was used to treat Opioid Use Disorder (OUD).

Uses

A novel selective 5-HT2C-receptor agonist for the treatment of obesity.

Definition

ChEBI: A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine substituted at position 1 by a methyl group and a t position 6 by a chloro group.

Mechanism of action

Lorcaserin acts at 5-HT2C receptors in the central nervous system (CNS), particularly the hypothalamus, to reduce appetite.

Side effects

  • constipation
  • dry mouth
  • excessive tiredness
  • pain in the back or muscles
  • headache
  • dizziness
  • difficulty falling asleep or staying asleep
  • anxiety

Synthesis

The synthesis of LORCASERIN is as follows:
Liquid precursor 53 11-HCl (0.5mmol) was placed into a test tube equipped with a magnetic stir bar. Anhydrous 44 AlCl3 (1.75 equiv according to starting material) was added and efficiently mixed to obtain a paste. The mixture was slowly heated (10°C/min) to 150°C and stirred overnight. A saturated solution of 54 NaCl was added and the mixture was cooled. The pH was adjusted to 9.5-10 using 1M NaOH and then extracted with EtOAc. The combined organic phases were washed with brine, dried over Na2SO4 and the solvent was evaporated under reduced pressure. The obtained crude mixture was analyzed using 1H NMR spectroscopy (estimated yield by 1H NMR was 62%).

LORCASERIN Preparation Products And Raw materials

Raw materials

Preparation Products

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LORCASERIN Suppliers

Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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China
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Shanghai Scientia Pharmaceutical Technology Co., Ltd.
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21-21-54301573 13917723525
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(86)21-51861981
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sales@scientiapharm.com
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China
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Chemsky(shanghai)International Co.,Ltd.
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021-50135380
Email
shchemsky@163.com
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China
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283
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Chemsky (shanghai) International Co.,Ltd
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021-50135380
Email
shchemsky@sina.com
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China
ProdList
15402
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China Langchem Inc.
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0086-21-58956006
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0086-21-58956100
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China
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Wuhan Sinocon New chemical Materials Co.,ltd.
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027-83229541 13971313286
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027-83096702
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whsinocon@aliyun.com
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China
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T&W GROUP
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021-61551611 13296011611
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+86 21-50676805
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contact@trustwe.com
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China
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S.Z. PhyStandard Bio-Tech. Co., Ltd.
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0755-83725681-603
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+86 755 28094224
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China
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4496
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UHN Shanghai Research & Development Co., Ltd.
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021-58958002 18930822973
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+86 (21) 5895-8628
Email
SALES@UHNSHANGHAI.COM
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China
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Shanghai Witofly Chemical Co.,Ltd
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Email
sales@witofly.com
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China
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2864
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View Lastest Price from LORCASERIN manufacturers

Hubei Langyou International Trading Co., Ltd
Product
LORCASERIN 616202-92-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10000kg/month
Release date
2023-02-27
Hangzhou ICH Biofarm Co., Ltd
Product
Lorcaserin 616202-92-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10tons
Release date
2023-07-12
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
Product
LORCASERIN 616202-92-7
Price
US $25.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
5000kg/month
Release date
2022-01-17

616202-92-7, LORCASERINRelated Search:


  • Apd 356
  • Apd356
  • Apd-356
  • Ar-10a
  • Unii-637E494o0z
  • LORCASERIN
  • (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
  • APD 356;APD356;APD-356;AR-10A;APD-356;APD 356;APD356
  • CS-1994
  • (1R)-8-Chloro-2,3,4,5-tetrahydro-1-Methyl-1H-3-benzazepine
  • Lotcaserin Freebase
  • LORCASERIN USP/EP/BP
  • cas856681-05-5 (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine
  • Lorcaserin(free base)
  • Lorcaserin powder
  • Lorcaserin D4 MaleateQ: What is Lorcaserin D4 Maleate Q: What is the CAS Number of Lorcaserin D4 Maleate Q: What is the storage condition of Lorcaserin D4 Maleate Q: What are the applications of Lorcaserin D4 Maleate
  • LorcaserinQ: What is Lorcaserin Q: What is the CAS Number of Lorcaserin Q: What is the storage condition of Lorcaserin
  • LORCASERIN API
  • Lorcaserin-[13C6]
  • 616202-92-7
  • 16202-92-7
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  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • 616202-92-7