Punicalagin

ChemicalBook > CAS DataBase List > Punicalagin

Description Antioxidant Activity

Product Name: Punicalagin
CAS No.: 65995-63-3
Chemical Name: Punicalagin
Synonyms: Punicalagins;Punicalagin;granatidine;Punicalagin A&B;Punicalagin(a+);PUNICALAGINS A&B;Punicalagin (40%);Punicalagin (98%);Punicalagin - 98% min;PULCHINENOSIDE B4(RG)
CBNumber: CB61040711
Molecular Formula: C48H28O30
Formula Weight: 1084.72
MOL File: 65995-63-3.mol

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Punicalagin Property

Melting point:: >155°C (dec.)
Density: 2.076±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: methanol: soluble5mg/mL, clear
pka: 1.92±0.60(Predicted)
form: powder
color: faint yellow to dark yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 2 months.
InChIKey: ZJVUMAFASBFUBG-UYMKNUMKSA-N
LogP: 1.442 (est)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29389090
Hazardous Substances Data: 65995-63-3(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0023
Product name: Punicalagin
Purity: ≥98% (HPLC), from pomegranate
Packaging: 1mg
Price: $96.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL80524
Product name: Punicalagin (A + B mixture)
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $342
Updated: 2024/03/01

Sigma-Aldrich

Product number: 50793
Product name: Punicalagin
Purity: analytical standard
Packaging: 10mg
Price: $740
Updated: 2024/03/01

Cayman Chemical

Product number: 13069
Product name: Punicalagin
Purity: ≥95% mixture of anomers
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 13069
Product name: Punicalagin
Purity: ≥95% mixture of anomers
Packaging: 5mg
Price: $94
Updated: 2024/03/01

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Punicalagin Chemical Properties,Usage,Production

Description

Punicalagin is an ellagitannin, a type of phenolic compound. It is found in forms alpha and beta in pomegranates (Punica granatum), in Terminalia catappa and Terminalia myriocarpa, and in Combretum molle, the velvet bushwillow, a plant species found in South Africa. These three genera are all Myrtales and the last two are both Combretaceae.
Punicalagins are water-soluble and hydrolyze into smaller phenolic compounds, such as ellagic acid. There were no toxic effects in rats on a 6% diet of punicalagins for 37 days. In laboratory research, punicalagins had carbonic anhydrase inhibitor activity.

Antioxidant Activity

Punicalagins are large molecules (ellagitannins) found in Pomegranates and Pomegranate Juice. They themselves are very potent anti-oxidants, and they can be metabolized into other compounds (ellagic acid, urolithins) that themselves have anti-oxidant capabilities (although lesser). This large anti-oxidant value of punicalagins, about thrice that of red wine and green tea, is what brought Pomegranates to fame. That being said, the overall amount of punicalagins that get into the bloodstream after oral ingestion is quite small (6% is the highest noted and was in rats, sometimes human studies don't even notice punicalagins in the blood). The ellagic acid and urolithins still confer a lot of health benefits, but their anti-oxidant capabilities are on par with green tea and red wine if not a bit less potent. There is a very high variation between individuals, and like daidzein (one of the soy isoflavones) it may be genetically dependent on what intestinal microflora one possesses.
Like green tea, pomegranate is also rich in polyphenolic flavonoids. The phenol punicalagin is responsible for more than 50% of the juice's potent antioxidant activity. It appears that pomegranate juice has higher levels of punicalagin because the rind is used in its production. In fact, there is actually more antioxidant activity from the tannins in the juice than there is in the fruit itself. A 2-year, single-center clinical trial was completed for 48 men with prostate cancer and a rising PSA level after either surgery or radiotherapy for the treatment of prostate cancer.

Description

Punicalagin (65995-63-3) is a polyphenolic compound isolated from pomegranates possessing antioxidant, anti-inflammatory, and antitumorigenic properties.1,2?It has been shown to reduce high glucose-induced neural tube defects by blocking cellular stress and caspase activation.3?Punicalagin prevented high-fat diet induced obesity associated accumulation of cardiac triglyceride and cholesterol as well as myocardial damage via AMPK mediated modulation of mitochondria and phase II enzymes.4

Uses

Punicalagin is a natural polyphenolic compound extracted from the fruit of Pomegranate and acts as an effective anti-inflammatory and anti-oxidant.

Definition

ChEBI: Punicalagin is a tannin.

References

1) Seeram?et al. (2005),?In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice; J. Nutr. Biochem.,?16?360 2) Adams?et al. (2006),?Pomegranate Juice, Total Pomegranate Ellagitannins, and Punicalagin Suppress Inflammatory Cell Signaling in Colon Cancer Cells; J. Agric. Food Chem.,?54?980 3) Zhong?et al. (2015),?Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects; Biochem. Biophys. Res. Commun.,?467?179 4) Cao?et al. (2015),?Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation; Sci. Rep.,?5?14014

Punicalagin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Punicalagin manufacturers

BINBO BIOLOGICAL CO.,LTD

Product: Punicalagin 65995-63-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 10% 20% 25% 40%
Supply Ability: 1000 kg
Release date: 2024-04-24

Hebei Kingfiner Technology Development Co.Ltd

Product: Punicalagin 65995-63-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 50000kg
Release date: 2024-05-23

Henan Fengda Chemical Co., Ltd

Product: Punicalagin 65995-63-3
Price: US $35.00-1.40/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-27

65995-63-3, PunicalaginRelated Search:

(-)-EGCG-3''-O-ME L-Epicatechin (-)-Epicatechin gallate Willow Bark Extract Isochlorogenic Acid B 3-Acetoxy-o-toluic acid Diphenic acid 4-Hydroxy-2,6-dimethylbenzoic acid Ellagic acid Punicalagin [1,1':3',1'']TERPHENYL-2'-CARBOXYLIC ACID 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether BIPHENYL-2,2'-DICARBOXYLIC ACID DIMETHYL ESTER 3-[(2-METHYLBENZYL)OXY]BENZALDEHYDE punicalin 4-HYDROXY-2,6-DIMETHYL-BENZENEMETHANOL 3,3'-DIPHENYLBIPHENYL DIETHYL BIPHENYL 2,2'-DICARBOXYLATE

Punicalagin

PULCHINENOSIDE B4(RG)

Punicalagin (98%)

Punicalagins

Punicalagins, 98%, from Punica granatum L.

Punicalagin (40%)

Punicalagin - 98% min

Punicalagin - Technical

D-Glucose, cyclic 4,6-[(2S,2'S)-2,2'-(5,10-dihydro-2,3,7,8-tetrahydroxy-5,10-dioxo[1]benzopyrano[5,4,3-cde][1]benzopyran-1,6-diyl)bis[3,4,5-trihydroxybenzoate]] cyclic 2,3-[(1S)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate]

Punicalagin A&B

2,3-(S)-Hexahydroxydiphenoyl-4,6-(S,S)-gallagyl-D-glucose

Punicalagin(a+)

TIANFUCHEM--65995-63-3--High purity Punicalagin in stock

pomegranate leaf extract

Punica granatum L. Terminalia catappa L. extract

Pomegranate extract, punicalagins

Pomegranate peel extract, punicalagins

PUNICALAGINS A&B

granatidine

Punicalagin(Mixture of Isomers)

65995-63-3

365995-63-3

C49H30O29

C48H28O30

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract