ChemicalBook > CAS DataBase List > Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

Product Name
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
CAS No.
176199-48-7
Chemical Name
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
Synonyms
LY 354740;Eglumetad;Eglumegad;(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid;Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S...;Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid,2-amino-,(1S,2S,5R,6S)-;Bicyclo[3.1.0]hexane-2,6-dicarboxylicacid, 2-aMino-, [1S-(1a,2b,5a,6a)]-;Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
CBNumber
CB61042715
Molecular Formula
C8H11NO4
Formula Weight
185.18
MOL File
176199-48-7.mol
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Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Property

Melting point:
270-271 °C
Boiling point:
376.4±32.0 °C(Predicted)
Density 
1.569
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
H2O : 6.33 mg/mL (34.18 mM; Need ultrasonic and warming)
form 
Powder
pka
2.06±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.04685
Product name
LY 354740 - CAS 176199-48-7 - Calbiochem
Packaging
10MG
Price
$156
Updated
2022/05/15
Cayman Chemical
Product number
24215
Product name
LY354740
Purity
≥95%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
24215
Product name
LY354740
Purity
≥95%
Packaging
5mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
24215
Product name
LY354740
Purity
≥95%
Packaging
10mg
Price
$160
Updated
2024/03/01
Tocris
Product number
3246
Product name
LY354740
Purity
≥98%(HPLC)
Packaging
10
Price
$208
Updated
2021/12/16
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Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Chemical Properties,Usage,Production

Uses

Treatment ofgeneral anxiety disorders and smoking cessation (metabotropic glutamate agonist).

Uses

LY 354740 is a highly selective and potent agonist of group II mGluR.

Definition

ChEBI: Eglumetad is a L-alpha-amino acid.

Biological Activity

Highly selective and potent agonist of group II mGlu receptors (EC 50 values are 5.1 and 24.3 nM at mGlu 2 and mGlu 3 receptors respectively and > 100000 nM at mGlu 4 , mGlu 7 , mGlu 1a and mGlu 5a receptors). Displays antianxiety and antiaddictive activity in vivo . Orally and systemically active.

storage

+4°C

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Suppliers

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176199-48-7, Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)Related Search:

DL-ALPHA-AMINOPIMELIC ACID Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) L-Cyclopropylglycine L-2-Aminoadipic acid (S)-1-CYCLOPROPYLETHYLAMINE Cycloleucine (2S,1'S,2'S)-2-(CARBOXYCYCLOPROPYL)GLYCINE DL-2-METHYLGLUTAMIC ACID 1-Amino-1-cyclohexanecarboxylic acid AMINO-CYCLOPROPYL-ACETIC ACID DL-ALPHA-AMINOSUBERIC ACID D-ALPHA-AMINOSUBERIC ACID H-ALPHA-ME-LEU-OH CHEMBRDG-BB 6156098 cis-1,3-cyclohexanedicarboxylic acid 1-AMINO-3-METHYLCYCLOHEXANECARBOXYLIC ACID TALAGLUMETAD 2-AMINO-2-CYCLOPROPYLPROPIONIC ACID

  • Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
  • Eglumegad
  • Eglumetad
  • LY 354740
  • (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
  • Bicyclo[3.1.0]hexane-2,6-dicarboxylicacid, 2-aMino-, [1S-(1a,2b,5a,6a)]-
  • Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid,2-amino-,(1S,2S,5R,6S)-
  • Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S...
  • 176199-48-7
  • CYCLOPENTANE
  • Glutamate