ChemicalBook > CAS DataBase List > Miltrione

Miltrione

Product Name: Miltrione
CAS No.: 27210-57-7
Chemical Name: Miltrione
Synonyms: Rosmariquinone;C13715;Miltiron;NSC 639662;minestrone;Miltrione USP/EP/BP;8,8-DIMETHYL-2-PROPAN-2-YL-6,7-DIHYDRO-5H-PHENANTHRENE-3,4-DIONE;5,6,7,8-Tetrahydro-2-isopropyl-8,8-diMethyl-3,4-phenanthrenedione;5,6,7,8-Tetrahydro-8,8-dimethyl-2-isopropyl-3,4-phenanthrenedione;2-Isopropyl-5,6,7,8-tetrahydro-8,8-dimethylphenanthrene-3,4-dione
CBNumber: CB61074910
Molecular Formula: C19H22O2
Formula Weight: 282.38
MOL File: 27210-57-7.mol

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Miltrione Property

Melting point:: 98-100℃ (hexane )
Boiling point:: 421.6±45.0 °C(Predicted)
Density: 1.094±0.06 g/cm3 (20 ºC 760 Torr)
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: powder
color: Red
LogP: 4.916 (est)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M344500
Product name: Miltirone
Packaging: 2.5mg
Price: $145
Updated: 2021/12/16

TRC

Product number: M344500
Product name: Miltirone
Packaging: 25mg
Price: $1205
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FM26008
Product name: Miltirone
Packaging: 25mg
Price: $1600
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FM26008
Product name: Miltirone
Packaging: 2mg
Price: $200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0026123
Product name: MILTIRONE
Purity: 95.00%
Packaging: 10MG
Price: $367.5
Updated: 2021/12/16

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Miltrione Chemical Properties,Usage,Production

Chemical Properties

Orange granular crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Salvia miltiorrhiza.

Uses

An active component in Salvia miltiorrhiza that has been shown to inhibit the increase in the abundance of the mRNA for the α4 subunit of the GABAA receptor induced by ethanol withdrawal in cultured hippocampal neurons. A potential phytotherapeutic agent in the treatment of alcohol dependence.

Definition

ChEBI: Miltirone is an abietane diterpenoid.

in vivo

Miltirone (10-60 mg/kg, p.o.; one hour before test) increases the number of punished crossings in the four-plate test in mice^[1].

Animal Model:	Mice^[1]
Dosage:	10, 30, 60 mg/kg
Administration:	Oral gavage (p.o.); an hour before test
Result:	Increased the number of punished crossings of mice in the 'Four-Plate Test'. Showed some reversal of the effect of diazepam as expected for a partial agonist. Produced no muscle relaxant effect and did not impair the performance of mice in the Julou-Courvoisier horizontal wire test.

IC 50

CES2: 0.04 μM (Ki)

Miltrione Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Miltrione manufacturers

Career Henan Chemical Co

Product: Miltrione 27210-57-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

27210-57-7, MiltrioneRelated Search:

Cryptotanshinone 3-METHYLPHENYLACETONE 2,4-DIMETHYLSTYRENE 5-METHYL-2,3-HEXANEDIONE 1,2-DIHYDRONAPHTHALENE 4-Methyl-1-phenyl-2-pentanone 1,2-NAPHTHOQUINONE 4-TERT-BUTYLSTYRENE 2-Methyl-4-(2-methylphenyl)but-1-ene trimethylcumene 2,5-DIMETHYLPHENYLACETONE Miltrione 1-M-TOLYL-PENTAN-1-ONE 2-Methyl-4-(3-methylphenyl)but-1-ene 2-5-dimethylbutyrophenone 1-(5,6,7,8-TETRAHYDRO-NAPHTHALEN-1-YL)-ETHANONE 1,5-DIMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE 2-(2,5-DIMETHYLPHENYL)ACETALDEHYDE

5,6,7,8-Tetrahydro-2-isopropyl-8,8-diMethyl-3,4-phenanthrenedione

5,6,7,8-Tetrahydro-8,8-diMethyl-2-(1-Methylethyl)-3,4-phenanthrenedione

2-Isopropyl-5,6,7,8-tetrahydro-8,8-dimethylphenanthrene-3,4-dione

5,6,7,8-Tetrahydro-8,8-dimethyl-2-isopropyl-3,4-phenanthrenedione

Rosmariquinone

C13715

Miltiron

NSC 639662

3,4-Phenanthrenedione,5,6,7,8-tetrahydro-8,8-dimethyl-2-(1-methylethyl)-

8,8-DIMETHYL-2-PROPAN-2-YL-6,7-DIHYDRO-5H-PHENANTHRENE-3,4-DIONE

Miltrione USP/EP/BP

minestrone

2-Isopropyl-8,8-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione

Gamma-aminobutyric acid Receptor,inhibit,acid,γ-Aminobutyric acid Receptor,GABA Receptor,neurotransmission,Miltirone,GABA,γ-aminobutyric,Inhibitor

27210-57-7

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