ChemicalBook > CAS DataBase List > Pyrogallol

Pyrogallol

Product Name
Pyrogallol
CAS No.
87-66-1
Chemical Name
Pyrogallol
Synonyms
benzene-1,2,3-triol;1,2,3-Benzenetriol;1,2,3-Trihydroxybenzene;Pyrogallo;Piral;pyrogallic;1,2,3-Trihydroxybenzen;PyrogaL;PYROGALL;fourrine85
CBNumber
CB6107909
Molecular Formula
C6H6O3
Formula Weight
126.11
MOL File
87-66-1.mol
More
Less

Pyrogallol Property

Melting point:
43-47 °C(lit.)
Boiling point:
309 °C
Density 
1.112 g/mL at 25 °C(lit.)
bulk density
600kg/m3
vapor density 
4.4 (vs air)
vapor pressure 
10 mm Hg ( 167.7 °C)
refractive index 
n20/D 1.387
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
water: soluble
form 
Very Fine Crystalline Powder
pka
pK1:9.03(0);pK2:11.63(+1) (25°C)
color 
White
PH
4-5 (50g/l, H2O, 20℃)
Water Solubility 
400 g/L (25 ºC)
Sensitive 
Light Sensitive
Merck 
14,8000
BRN 
907431
Stability:
Stable, but decolourises in light. Combustible. Incompatible with strong oxidising agents, alkalies, metal oxides, ammonia, antipyrine, phenol, iodine, lime water, menthol, potassium permanganate, strong bases.
InChIKey
WQGWDDDVZFFDIG-UHFFFAOYSA-N
LogP
-0.47
CAS DataBase Reference
87-66-1(CAS DataBase Reference)
NIST Chemistry Reference
1,2,3-Benzenetriol(87-66-1)
EPA Substance Registry System
Pyrogallol (87-66-1)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-52/53-68-40-36/38
Safety Statements 
22-24/25-61-36/37-26
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
UX2800000
F 
8
TSCA 
Yes
HS Code 
2907 29 00
HazardClass 
6.1
PackingGroup 
III
Hazardous Substances Data
87-66-1(Hazardous Substances Data)
Toxicity
LD50 orally in rabbits: 1.6 g/kg (Dollahite)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H341Suspected of causing genetic defects

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89772
Product name
Pyrogallol
Purity
phyproof? Reference Substance
Packaging
100MG
Price
$262
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22302
Product name
Pyrogallol
Purity
for synthesis
Packaging
50g
Price
$79.1
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22302
Product name
Pyrogallol
Purity
for synthesis
Packaging
250g
Price
$322
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22302
Product name
Pyrogallol
Purity
for synthesis
Packaging
1kg
Price
$579
Updated
2024/03/01
Sigma-Aldrich
Product number
16040
Product name
Pyrogallol
Purity
ACS reagent, ≥99%
Packaging
100g
Price
$154
Updated
2024/03/01
More
Less

Pyrogallol Chemical Properties,Usage,Production

Description

Pyrogallol is a natural oxidant that can generate superoxide (O2-) in alkaline solutions through autoxidation to a semiquinone radical. Importantly, the semiquinone radical can react with O2- in an acidic environment to produce a quinone and H2O2. Pyrogallol autoxidation is used in superoxide dismutase activity assays. It can also be used in assays to assess antioxidant capacity. Pyrogallol is used in some biological systems as an O2- scavenger. In other biological systems, it is used as an O2- generator. Pyrogallol effectively scavenges DPPH radical and ABTS+ in vitro. Pyrogallol is a product of tannin degradation to gallic acid by ruminant microbes and has hepatotoxic and nephrotoxic effects in vivo.

Chemical Properties

White or nearly white needle- or leaf-shaped crystals or crystalline powder.Pyrogallol is practically odorless.

Chemical Properties

white crystalline solid

Uses

Complexing agent; reducing agent; alkaline solution indicator for gaseous oxygen.

Uses

Pyrogallol is used in the manufacture of various dyes; in dyeing furs, hairs, and feathers; for staining leather; in engraving;as a developer in photography; and as an analytical reagent..

Uses

Pyrogallol possesses importance as a spectrophotometric reagent in the determination of niobium and tantalum. The absorptions of niobium and tantalum complexes are usually measured at 340 and 335 nm, respectively. The niobium complex is formed in slightly acidic medium, and the tantalum complex in strongly acidic medium (4 N HC1). The absorption spectra are pH-dependen.

Production Methods

Pyrogallol is prepared by heating dried gallic acid at about 200°C with the loss of carbon dioxide or by the chlorination of cyclohexanol to tetrachlorocyclohexanone, followed by hydrolysis.

Definition

ChEBI: A benzenetriol carrying hydroxy groups at positions 1, 2 and 3.

General Description

Odorless white to gray solid. Sinks and mixes with water.

Air & Water Reactions

Turns gray on exposure to light or air. Water soluble.

Reactivity Profile

Pyrogallol is a strong reducing agent. Reacts with alkalis, NH3, antipyrine, camphor, phenol, iron and lead salts, iodine, lime water, menthol and KMnO4.

Hazard

Toxic by ingestion and skin absorption.

Health Hazard

The toxic symptoms are similar to those of phenol. It can enter the body by absorption through skin and ingestion. The poisoning effects are nausea, vomiting, gastritis, hemolysis, methemoglobinemia, kidney and liver damage, convulsions, and congestion of lungs. High doses can cause death. Ingestion of 2–3 g of solid can be fatal to humans. The LD50 values varied widely in species. The oral LD50 value in mice is about 300 mg/kg.

Health Hazard

Inhalation of dust causes irritation of nose and throat. Ingestion may cause severe gastrointestinal irritation, convulsions, circulatory collapse, and death. Contact with eyes causes irritation. Skin contact can cause local discoloration, irritation, eczema, and death; repeated contact can cause sensitization.

Fire Hazard

Pyrogallol is probably combustible.

Contact allergens

Pyrogallol belongs to the phenols group. It is an old photograph developer and a low sensitizer in hair dyes.

Biochem/physiol Actions

Pyrogallol also referred to as 1,2,3-trihydroxybenzene inhibits the response to nitric oxide (NO) in the rat anococcygeus muscle.

Safety Profile

Human poison by ingestion and subcutaneous routes. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. 1 198 PPRSOO PYROSULFURYL CHLORIDE Readdy absorbed through the skin. Human systemic effects by ingestion: convulsions, dyspnea, gastrointestinal effects. A severe skin and eye irritant. Incompatible with alkalies, NH3, antipyrine, phenol, iron and lead salts, iodine, KMn04. When heated to decomposition it emits acrid smoke and irritating fumes. Used as a topical antibacterial agent, as an intermediate, hair dye component, and analytical reagent.

Carcinogenicity

Pyrogallol was not carcinogenic in mouse and rabbit chronic dermal studies. Mice were treated twice weekly with pyrogallol in acetone (50%) on the shaved flank for life. There was no increase in dermal or systemic tumors. A similar study in rabbits also revealed no skin tumors, although positive controls showed an increase in tumors in both mice and rabbits.
Pyrogallol was considered to be cocarcinogenic when administered dermally three times a week together with the skin carcinogen benzo[a]pyrene for 440 days; pyrogallol administered alone caused no increase in skin tumors.

Pyrogallol Preparation Products And Raw materials

Raw materials

Preparation Products

Coenzyme Q10 BENDIOCARB Exifone GALLEIN 4-Hydroxybutyl acrylate 1,2,3-Trimethoxybenzene 1-CHLOROMETHYL-2,3,4-TRIMETHOXYBENZENE 7,8-DIHYDROXY-4-METHYLCOUMARIN 1,4-BUTANEDIOL DIACRYLATE Gallamine triethiodide Atracurium besylate
More
Less

Pyrogallol Suppliers

Americas 1 Australia 2 Belgium 3 Brazil 2 Canada 5 China 548 Czech Republic 3 Europe 4 France 5 Germany 10 Hungary 1 India 48 Italy 1 Japan 8 Poland 2 Slovakia 1 South Korea 3 Switzerland 3 The Netherlands 2 Ukraine 2 United Kingdom 17 United States 85 USA 1 Global 757
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
GFS Chemicals, Inc.
Tel
--
Fax
--
Email
Development@gfschemicals.com
Country
United States
ProdList
338
Advantage
58
CALSAK CORPORATION
Tel
--
Fax
--
Email
calsak@calsak.com
Country
United States
ProdList
430
Advantage
58
Wego Chemical Group
Tel
--
Fax
--
Email
sales@wegochem.com
Country
United States
ProdList
443
Advantage
58
Penta Manufacturing Company (a division of Penta International Corporation)
Tel
--
Fax
--
Email
@pentamfg.com
Country
United States
ProdList
901
Advantage
58
Alan Scientific Inc.
Tel
--
Fax
--
Email
sales@alanscientific.com
Country
United States
ProdList
51
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
RIA International LLC
Tel
--
Fax
--
Email
marketing@riausa.net
Country
United States
ProdList
1324
Advantage
50
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
Redox Scientific
Tel
--
Fax
--
Email
info@redoxsci.com
Country
United States
ProdList
2380
Advantage
58
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Biddle Sawyer Corporation
Tel
--
Fax
--
Email
bsc@biddlesawyer.com
Country
United States
ProdList
260
Advantage
58
TCI America, Inc. (part of Tokyo Chemical Industry)
Tel
--
Fax
--
Email
Angelina.Crew@tcichemicals.com
Country
United States
ProdList
2053
Advantage
58
Charkit Chemical Corporation
Tel
--
Fax
--
Email
sales@charkit.com
Country
United States
ProdList
2993
Advantage
65
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Penta International Corporation
Tel
--
Fax
--
Email
lisaa@pentamfg.com
Country
United States
ProdList
5042
Advantage
58
Glentham Life Sciences Ltd
Tel
--
Fax
--
Email
info@glentham.com
Country
United States
ProdList
2026
Advantage
58
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
GFS Chemicals Inc
Tel
--
Fax
--
Email
service@gfschemicals.com
Country
United States
ProdList
2328
Advantage
58
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Cenorx
Tel
--
Fax
--
Email
info@cenorx.com
Country
United States
ProdList
73
Advantage
50
ECA International Corporation
Tel
--
Fax
--
Email
services@ecacorporation.com
Country
United States
ProdList
1062
Advantage
52
Ring Specialty Chemicals Inc.
Tel
--
Fax
--
Email
info@ringchemicals.com
Country
United States
ProdList
888
Advantage
39
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
Sisco Research Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
srlmarketing@dishnetdsl.net
Country
United States
ProdList
1905
Advantage
64
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Sinova Inc.
Tel
--
Fax
--
Email
sales@sinovainc.com
Country
United States
ProdList
4009
Advantage
58
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
More
Less

View Lastest Price from Pyrogallol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Pyrogallol 87-66-1
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-16
HebeiShuoshengImportandExportco.,Ltd
Product
Pyrogallol 87-66-1
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-07
Hebei Saisier Technology Co., LTD
Product
Pyrogallol 87-66-1
Price
US $6.00/KG
Min. Order
1KG
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-04-16

87-66-1, PyrogallolRelated Search:

Phloroglucinol Phloroglucinol dihydrate 3-Hydroxy-4,5-dimethoxybenzoic acid Gallic acid monohydrate 3,4,5-Trimethoxybenzoyl chloride Colchicine Octyl gallate Syringic acid METHYL-BETA-D-GALACTOPYRANOSIDE 2,3,4-Trimethoxybenzoic acid PYROGALLOL-4-CARBOXYLIC ACID,PYROGALLOL CARBOXYLIC ACID 3,4,5-TRIETHOXYBENZOIC ACID Propyl gallate PYROGALLOL MONOMETHYL ETHER,PYROGALLOL-1-METHYL ETHER,PYROGALLOL 1-MONOMETHYL ETHER 3,4,5-Trimethoxyphenylacetonitrile 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID 3,4,5-Trimethoxy benzoic acid 2,3,4-TRIMETHOXYBENZONITRILE

  • 1,2,3-Trihydroxybenzen
  • 1,2,3-trihydroxy-benzen
  • 1,2,3-trihydroxybenzen(czech)
  • 1,2,3-trihydroxybenzene(pyrogallol)
  • 2,3-Dihydroxyphenol
  • Benzene, 1,2,3-trihydroxy-
  • benzene-1,2,3-triol
  • C.I. Oxidation Base 32
  • c.i.oxidationbase32
  • cioxidationbase32
  • Fouramine base ap
  • Fouramine Brown AP
  • fouraminebrownap
  • Fourrine 85
  • Fourrine PG
  • fourrine85
  • fourrinepg
  • Piral
  • pyrogallic
  • PYROGALLOL TRIMETHYL ETHER
  • PYROGALLIC ACID TRIMETHYL ETHER
  • PYROGALLOL (1,2,3-TRIHYDROXYBENZENE)
  • Pyrogallol (Pyrogallic Acid)
  • PYROGALLOL extrapure AR
  • 1,2,3-Trihydroxybenzene, Pyrogallolum
  • Pyrogallol, Crystal, Reagent
  • Pyrogallol ,99%
  • 1,2,3-Benzenetriol
  • 1,2,3-Trihydroxybenzene
  • C.I. 76515
  • Pyrogallol
  • ISOCINCHOMERONIC ACID(RG)
  • PYROGALLOL, >=98% (HPLC)
  • 1,2,3-Trihydroxybenzene Pyrogallol Pyrogallic acid 1,2,3-Benzenetriol
  • Coke gallic acid
  • Pyrogallo
  • Pyrogallol, 99.8%
  • Phloroglucinol Impurity A
  • Focus of gallic acid
  • Pyrogallol, 99% 500GR
  • (1S,3R)-1-(2-Nitrophenyl)ethylcarboxyaminocyclopentane-1,3-dicarboxylicacid
  • NPEC-caged-(1S,3R)-ACPD
  • Pyrogallol solution,1,2,3-Trihydroxybenzene
  • Pyrogallol, synthesis grade
  • Spiro[3H-2,1-benzoxanthiole-3,9′-xanthene]3′,4′,5′,6′-tetrol-1,1-dioxide
  • Phloroglucinol Impurity 1
  • Benzene-1,2,3-triol 98+%
  • 1-(2,3-Dichlorophenyl)piperazine dimer
  • Pyrogallol 87-66-1 1,2,3-Trihydroxybenzene
  • 1,2,3-Trihydroxybenzene 87-66-1 Pyrogallol
  • Pyrogallol 87-66-1
  • PYROGALLOL, REAGENT (ACS)PYROGALLOL, REAGENT (ACS)PYROGALLOL, REAGENT (ACS)
  • Alkaline pyrogallic acid test solution(ChP)
  • AMPK&gamma
  • Pyrogallic, AR
  • Pyrogallic, >99.0%(GC)
  • -AMP-Activated Protein Kinase Subunit gamma-3, AMPK gamma3, AMPK Subunit gamma-3, PRKAG3, AMPKG3, AMPKy3, AMPK-y3,)
  • 1,2,3-TRIHYDROXYBENZENE TRIMETHYL ETHER