Calpain Inhibitor I
- Product Name
- Calpain Inhibitor I
- CAS No.
- 110044-82-1
- Chemical Name
- Calpain Inhibitor I
- Synonyms
- LLNL;ALLN;MG 101;ac-llnl-cho;MG-101 (ALLN);InSolution? ALLN;CALPAIN INHIBITOR;AC-LL-NORLEUCINAL;Ac-Leu-Leu-Nle-al;AC-LEU-LEU-NLE-CHO
- CBNumber
- CB6108214
- Molecular Formula
- C20H37N3O4
- Formula Weight
- 383.53
- MOL File
- 110044-82-1.mol
Calpain Inhibitor I Property
- Melting point:
- 182 °C
- Boiling point:
- 510.42°C (rough estimate)
- Density
- 1.1322 (rough estimate)
- refractive index
- 1.6300 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble
- form
- powder
- pka
- 13.53±0.46(Predicted)
- color
- white
- biological source
- synthetic (organic)
- Water Solubility
- Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers.
- BRN
- 7656053
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 208719
- Product name
- ALLN
- Packaging
- 5mg
- Price
- $120
- Updated
- 2025/07/31
- Product number
- 208719
- Product name
- ALLN
- Packaging
- 25mg
- Price
- $312
- Updated
- 2025/07/31
- Product number
- 11086090001
- Product name
- Calpain Inhibitor I
- Purity
- N-Acetyl-Leu-Leu-norleucinal,synthetic
- Packaging
- 25mg
- Price
- $350
- Updated
- 2025/07/31
- Product number
- 14921
- Product name
- Calpain Inhibitor I
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $31
- Updated
- 2024/03/01
- Product number
- 14921
- Product name
- Calpain Inhibitor I
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $61
- Updated
- 2024/03/01
Calpain Inhibitor I Chemical Properties,Usage,Production
Description
ALLN (110044-82-1) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190 nM), calpain II (Ki=150 nM), cathepsin L (Ki=0.5 nM) and other neutral cysteine proteases.1?Inhibits cell cycle progression at G1/S?and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation.2?Inhibits proteolytic degradation of IκBα and IκBβ in RAW macrophages induced with LPS.3?Blocks AIF-mediated necroptosis.4?Cell permeable.
Chemical Properties
white to off-white powder
Uses
Calpain inhibitor I reversibly blocks the calcium-dependent neutral cysteine protease calpain I. Calpains have been implicated in various cellular processes, including cell proliferation, apoptosis, and cell differentiation.
Uses
Calpain inhibitor I inhibits calpain, which activates myosin light chain kinase and protein kinase C by partial proteolysis. The inhibitor should be membrane permeable due to low molecular weight and lack of charged residues.
Calpain Inhibitor I is used for western blotting methods.
Uses
It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. ALLN inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex. ALLN also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
Definition
ChEBI: A tripeptide composed of N-acetylleucyl, leucyl and norleucinal residues joined in sequence.
General Description
Calpain Inhibitor I is a strong, competitive inhibitor of the Ca2+-dependent neutral cysteine proteases calpain I and calpain II.
Biological Activity
Calpain inhibitor (IC 50 = 0.09 μ M) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro . Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.
Biochem/physiol Actions
Calpain Inhibitor I inhibits tumor necrosis factor-induced (TNF-induced) cleavage of Poly (ADP-ribose) polymerase (PARP) and calpastatin in apoptosis. It also inhibits oxygen/glucose deprivation (OGD) induced cleavage of caspase-12 and Bcl-xL..
References
[1] T SASAKI. Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins.[J]. Journal of enzyme inhibition, 1990, 3 3: 195-201. DOI:10.3109/14756369009035837
[2] S W SHERWOOD. In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1993, 90 8: 3353-3357. DOI:10.1073/pnas.90.8.3353
[3] N-acetyl-leucinyl-leucinyl-norleucinal inhibits lipopolysaccharide-induced NF-kappaB activation and prevents TNF and IL-6 synthesis in vivo
[4] LEI SHANG. Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure.[J]. BMC Neuroscience, 2014, 15: 63. DOI:10.1186/1471-2202-15-63
Calpain Inhibitor I Preparation Products And Raw materials
Raw materials
Preparation Products
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