ChemicalBook > CAS DataBase List > 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
- Product Name
- 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
- CAS No.
- 306960-77-0
- Chemical Name
- 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
- Synonyms
- EOS-61863;2-(Trifluoromethyl)pyrimidine-5-carboxylicaci;2-(Trifluoromethyl)-5-pyrimidinecarboxylic Acid;2-(Trifluoromethyl)pyrimidine-5-carboxylic acid;5-PyriMidinecarboxylic acid, 2-(trifluoroMethyl)-;2-(Trifluoromethyl)pyrimidine-5-carboxylicacid,97%;5-Pyrimidinecarboxylic acid, 2-(trifluoromethyl)- (9CI);2-(Trifluoromethyl)pyrimidine-5-carboxylic acid ISO 9001：2015 REACH
- CBNumber
- CB61082227
- Molecular Formula
- C6H3F3N2O2
- Formula Weight
- 192.1
- MOL File
- 306960-77-0.mol
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2-(Trifluoromethyl)pyrimidine-5-carboxylic acid Property
- Melting point:
- 170-175℃
- Boiling point:
- 220.7±40.0 °C(Predicted)
- Density
- 1.575±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- powder
- pka
- 2.23±0.10(Predicted)
- color
- Pale yellow
- Water Solubility
- Slightly soluble in water.
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Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-60-36/37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29335990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 740446
- Product name
- 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
- Purity
- 97%
- Packaging
- 500mg
- Price
- $140
- Updated
- 2023/06/20
TRC
- Product number
- T895700
- Product name
- 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC50209
- Product name
- 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $68
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 041240
- Product name
- 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $152
- Updated
- 2021/12/16
AK Scientific
- Product number
- X5569
- Product name
- 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
- Packaging
- 500mg
- Price
- $164
- Updated
- 2021/12/16
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2-(Trifluoromethyl)pyrimidine-5-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White to pale yellow solid
Uses
2-(Trifluoromethyl)pyrimidine-5-carboxylic acid is used as pharmaceutical intermediate.
Synthesis
304693-64-9
306960-77-0
General procedure for the synthesis of 2-(trifluoromethyl)pyrimidine-5-carboxylic acid from ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate: To a 1 M aqueous lithium hydroxide solution (380 mL, 379.3 mmol) was added a solution of ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate (56.8 g, 252.8 mmol) dissolved in tetrahydrofuran (THF, 500 mL). The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, it was concentrated under vacuum to remove the organic solvent. The remaining aqueous solution was acidified with concentrated hydrochloric acid to pH 1. The resulting precipitate was collected by vacuum filtration to afford 44.4 g (91% yield) of 2-trifluoromethylpyrimidine-5-carboxylic acid as an off-white powder. The product was confirmed by 1H NMR (500 MHz, DMSO-d6): δ 9.44 (s, 2H). retention time (Rt) = 0.81 min by LCMS (Analytical Method A), and mass spectra (ESI negative ion mode): m/z = 190.9 ([M-H]-).
References
[1] Patent: WO2016/91776, 2016, A1. Location in patent: Page/Page column 362; 363
[2] Journal of medicinal chemistry, 2000, vol. 43, # 21, p. 3995 - 4004
[3] Patent: US2009/131431, 2009, A1. Location in patent: Page/Page column 148
[4] Patent: WO2007/36733, 2007, A1. Location in patent: Page/Page column 223
2-(Trifluoromethyl)pyrimidine-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid 306960-77-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
Career Henan Chemical Co
- Product
- 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid 306960-77-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-02
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