4-(4-AMINOPHENYL)-PIPERIDINE
- Product Name
- 4-(4-AMINOPHENYL)-PIPERIDINE
- CAS No.
- 113310-52-4
- Chemical Name
- 4-(4-AMINOPHENYL)-PIPERIDINE
- Synonyms
- 4-(4-Piperidyl)aniline;4-(4-piperidinyl)aniline;4-(Piperidin-4-yl)benzenamine;Benzenamine, 4-(4-piperidinyl)-;4-(4-Aminophenyl)-piperidine HCl
- CBNumber
- CB61118898
- Molecular Formula
- C11H16N2
- Formula Weight
- 176.26
- MOL File
- 113310-52-4.mol
4-(4-AMINOPHENYL)-PIPERIDINE Property
- Boiling point:
- 328.3±42.0 °C(Predicted)
- Density
- 1.043±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 10.34±0.10(Predicted)
- Appearance
- Off-white to pink Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P992350
- Product name
- 4-(Piperidin-4-yl)aniline
- Packaging
- 500mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- 0097DA
- Product name
- 4-(Piperidin-4-yl)aniline
- Packaging
- 250mg
- Price
- $123
- Updated
- 2021/12/16
- Product number
- 0097DA
- Product name
- 4-(Piperidin-4-yl)aniline
- Packaging
- 1g
- Price
- $232
- Updated
- 2021/12/16
- Product number
- A293511
- Product name
- 4-(Piperidin-4-yl)aniline
- Purity
- 97%
- Packaging
- 250mg
- Price
- $47
- Updated
- 2021/12/16
- Product number
- A293511
- Product name
- 4-(Piperidin-4-yl)aniline
- Purity
- 97%
- Packaging
- 1g
- Price
- $47
- Updated
- 2021/12/16
4-(4-AMINOPHENYL)-PIPERIDINE Chemical Properties,Usage,Production
Synthesis
26905-03-3
113310-52-4
Under argon protection, 4-(4-nitrophenyl)piperidine (400 mg, 1.942 mmol) was dissolved in methanol (30 mL) and palladium catalyst (144 mg) was added. Argon was replaced with hydrogen and the reaction was stirred at room temperature for 3.5 hours. Upon completion of the reaction, the palladium catalyst was removed by filtration and the solvent was removed by concentration under reduced pressure. The residue was purified by dichloromethane milling to give 4-(piperidin-4-yl)aniline (340 mg, 99% yield) as a white solid.HPLC analysis showed a purity of 95.0% [retention time R = 6.74 min, mobile phase 30% methanol/0.1% trifluoroacetic acid aqueous solution, run time 20 min].1H NMR (400 MHz, methanol-d4) δ 6.99 (d, J = 8.4 Hz, 2H), 6.69 (d, J = 8.4 Hz, 2H), 3.46-3.22 (m, 2H), 2.95 (td, J = 12.8, 3.0 Hz, 2H), 2.70-2.62 (m, 1H), 1.96-1.84 (m, 2H), 1.82-1.70 (m, 2H).LC -MS (ESI+) m/z 177.13808 [M + H]+. HRMS (ESI+) m/z Calculated C11H16N2 [M + H]+ 177.1386, measured 177.1382.
References
[1] Patent: WO2015/21149, 2015, A1. Location in patent: Page/Page column 99
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 6, p. 2746 - 2763
4-(4-AMINOPHENYL)-PIPERIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-(4-AMINOPHENYL)-PIPERIDINE Suppliers
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