Midodrine hydrochloride

ChemicalBook > CAS DataBase List > Midodrine hydrochloride

Midodrine hydrochloride

Product Name: Midodrine hydrochloride
CAS No.: 3092-17-9
Chemical Name: Midodrine hydrochloride
Synonyms: GUTRON;AMATINE;ST-1085;HIPERTAN;MIDODRINE;METLIGINE;PROAMATINE;MIDODRINE HCL;Prestwick_625;MIDODRINE HYDROCHLORIDE
CBNumber: CB6117144
Molecular Formula: C12H19ClN2O4
Formula Weight: 290.74
MOL File: 3092-17-9.mol

Less

Midodrine hydrochloride Property

Melting point:: 192-193°C
storage temp.: -20°C Freezer
InChIKey: MGCQZNBCJBRZDT-UHFFFAOYSA-N
CAS DataBase Reference: 3092-17-9(CAS DataBase Reference)

Less

Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: AB4343000
HS Code: 29242990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M8277
Product name: Midodrine hydrochloride
Purity: analytical standard, for drug analysis
Packaging: 1g
Price: $377
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1443704
Product name: Midodrine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: M8277
Product name: Midodrine hydrochloride
Purity: analytical standard, for drug analysis
Packaging: 50mg
Price: $114
Updated: 2024/03/01

Usbiological

Product number: M3895-06K
Product name: Midodrine, Hydrochloride
Packaging: 10mg
Price: $403
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0024416
Product name: MIDODRINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $418
Updated: 2021/12/16

Less

Midodrine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Gutron,Hormonchemie,W. Germany,1977

Uses

morphine antagonist

Uses

A phenylalkanolamine derivative which has been found to be effective in treating hypertensive conditions due to their long lasting blood pressure increasing effects

Definition

ChEBI: A hydrochloride resulting from the combination of equimolar amounts of midodrine and hydrogen chloride. Midodrine is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. The hydrochloride salt is used as a periph ral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Manufacturing Process

19.5 parts of carbobenzoxyglycine, 7.1 parts of triethylamine and 162 parts ofdry toluene are mixed with 11.2 parts of isovaleric acid chloride at 0°C toform the mixed anhydride and the mixture is agitated for two hours at 0°C.32.4 parts of 1-(2',5'-dimethoxyphenyl)-2-aminoethanol-(1) are then added,the mixture is agitated for four hours at a temperature between 0°C and+10°C and then left to stand overnight at that temperature. A thick crystalpaste forms. The reaction product is dissolved in 450 parts of ethyl acetateand 200 parts of water. The ethyl acetate solution is separated, washed withhydrochloric acid, sodium bicarbonate solution and water, dried over sodiumsulfate and inspissated. The inspissation residue is digested with 342 parts ofxylene, the required product crystallizing out. 34.9 parts of 1-(2',5'-dimethoxyphenyl)-2-(N-carbobenzoxyglycineamido)-ethanol-(1) are obtained.66.2 parts of 1-(2',5'-dimethoxyphenyl)-2-(N-carbobenzoxyglycineamido)-ethanol-(1) are hydrogenated in the presence of 6.6 parts of palladium carbon(10%) in 2,000 parts of glacial acetic acid. When no more hydrogen isabsorbed (3 mols of hydrogen are used), hydrogenation stops. The catalyst isremoved by suction and the equivalent quantity of hydrochloric acid in ethanolis added to the filtrate with agitation. During further agitation at roomtemperature 28.6 parts of crude 1-(2',5'-dimethoxyphenyl)-2-glycineamidoethanol-(1)hydrochloride crystallize, and are isolated andrecrystallized from water-methanol for purification. 22.1 parts of pure productare obtained with a melting point of 192°C to 193°C.
An alternative synthesis route is described by Kleeman and Engel.

brand name

Orvaten (UpsherSmith); Proamatine (Shire).

Therapeutic Function

Peripheral vasotonic, Antihypotensive

General Description

Midodrine is the N-glycyl prodrug ofthe selectiveα1-agonist desglymidodrine. Removal of theN-glycyl moiety from midodrine occurs readily in the liver aswell as throughout the body, presumably by amidases.Midodrine is orally active and represents another example ofa dimethoxy-β-phenylethylamine derivative that is used therapeuticallyfor its vasoconstrictor properties. Specifically, it isused in the treatment of symptomatic orthostatic hypotension.

Clinical Use

Treatment of orthostatic hypotension, including dialysis related hypotension

Drug interactions

Potentially hazardous interactions with other drugs
Adrenergic neurone blockers: midodrine antagonises hypotensive effect.
Anaesthetics: risk of arrhythmias if given with volatile anaesthetics.
Antidepressants: risk of arrhythmias and hypertension if given with tricyclic antidepressants, MAOIs and moclobemide.
Antihypertensives: antagonise hypertensive effect of midodrine; risk of severe hypertension if given with beta-blockers.
Dopaminergics: avoid with rasagiline and selegiline.
Other drugs which increase blood pressure: enhanced hypertensive effect.

Metabolism

Undergoes enzymatic hydrolysis in the systemic circulation to an active metabolite (desglymidodrine)

Midodrine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Midodrine hydrochloride Suppliers

Canada 3 China 83 Europe 2 France 1 Germany 2 India 12 Ireland 1 Italy 2 Malaysia 1 Switzerland 1 United Kingdom 6 United States 24 Global 138

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: Sales@changyanchem.cn
Country: China
ProdList: 5010
Advantage: 55

Chengdu Aupone Pharmaceutical Co.,Ltd.

Tel: 18980796919
Email: 236656639@qq.com
Country: China
ProdList: 23
Advantage: 58

Olix (Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 17316404525
Email: 209533805@qq.com
Country: China
ProdList: 9762
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18042
Advantage: 56

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4943
Advantage: 58

Shenzhen Nexconn Pharmatechs Ltd.

Tel: 0755-89396905
Email: admin@nexconn.com
Country: China
ProdList: 299
Advantage: 55

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9958
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Lancrix Chemicals

Tel: 86-21-50817262
Fax: 86-21-57712035
Email: sales@lancrix.com
Country: China
ProdList: 1502
Advantage: 55

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973186 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 18338
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-59402396 13419635609
Fax: 027-83989310
Email: 13419635609@163.com
Country: China
ProdList: 1966
Advantage: 55

Wuhan Magic Biological Technology Co., Ltd.

Tel: 18872289958、027-52304252、3400508168
Fax: 027-52304252
Email: 3400508168@qq.com
Country: China
ProdList: 1910
Advantage: 55

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 4015
Advantage: 58

Wuhan Zonvsicom chemicals Co.,Ltd.

Tel: 15623071665
Fax: 027-59257948
Email: sales@zvsicom.com
Country: China
ProdList: 299
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10295
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3251
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57412
Advantage: 58

Wuhan Fortuna Chemical Co., Ltd

Tel: +86-027-59207850
Fax: 86-27-59524646
Email: info@fortunachem.com
Country: China
ProdList: 5978
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52849
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15354
Advantage: 58

Hubei Xingcheng Biotechnology Co., Ltd

Tel: 19171210221
Fax: QQ:3505191060
Email: 3371991952@qq.com
Country: China
ProdList: 958
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39894
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49374
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569262 +86-15319487004
Fax: 029-88380327
Email: 1015@dideu.com
Country: China
ProdList: 2127
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-81138252 +86-18789408387
Fax: 029-88380327
Email: 1057@dideu.com
Country: China
ProdList: 3958
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-81148696 +86-15536356810
Email: 1022@dideu.com
Country: China
ProdList: 3882
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4195
Advantage: 58

Chongqing Kangzhou Zhitong Pharmaceutical Technology Co., Ltd.

Tel: 173-08362167 17308362167
Email: 3090602484@qq.com
Country: China
ProdList: 568
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: info@synzest.com
Country: China
ProdList: 9286
Advantage: 58

Wuhan Dingxintong Pharmaceutical Co. , Ltd.

Tel: 027-027-52344656 15871722230
Fax: 2796190295
Email: 15871722230@163.com
Country: China
ProdList: 4854
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4495
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7973
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44458
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 31121
Advantage: 58

Shenzhen Shengda Pharmaceutical co Limited

Tel: 0755-85269922 13424394241
Fax: QQ:1799060443
Email: sales@shengdapharm.com
Country: China
ProdList: 505
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-61856358 15229202216
Fax: 029-88380327
Email: 1020@dideu.com
Country: China
ProdList: 10007
Advantage: 58

Shanghai F.R. Chemical Technology Co.,Ltd

Tel: 021-52230662 13795399395
Email: sales@frchem.cn
Country: China
ProdList: 205
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 18351873721
Email: helen.zhang@synzest.com
Country: China
ProdList: 8295
Advantage: 58

Less

View Lastest Price from Midodrine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Midodrine hydrochloride 3092-17-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-03

Shaanxi Dideu Medichem Co. Ltd

Product: Midodrine hydrochloride 3092-17-9
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 2000tons
Release date: 2019-12-31

Shaanxi Dideu Medichem Co. Ltd

Product: Midodrine hydrochloride 3092-17-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-05

3092-17-9, Midodrine hydrochlorideRelated Search:

N,N-Dimethylacetamide Acetaminophen Methoxydiethylborane Diphenyldiethoxysilane Acetamide Doxycycline hydrochloride Ritodrine hydrochloride 2-Ethylphenylhydrazine hydrochloride Topotecan hydrochloride 4-Methoxyphenylacetone Difenidol hydrochloride Thioacetamide Minocycline hydrochloride (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride Mianserin hydrochloride Hydrochloric acid MIDODRINE MIDODRINE-D6 HCL

[+/-]-1-[2,5-DIMETHOXYPHENYL]-2-GLYCINAMIDOETHANOL HYDROCHLORIDE

AMATINE

METLIGINE

HIPERTAN

GUTRON

2-amino-n-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-acetamidmonohydrochlo

acetamide,2-amino-n-(beta-hydroxy-2,5-dimethoxyphenethyl)-,monohydrochloride,

PROAMATINE

MIDODRINE HCL

MIDODRINE HYDROCHLORIDE

MIDODRINE

ST-1085

ST-1085, Amatine, Gutron, Hipertan, Metligine, ProAmatine,

(±)-1-(2,5-dimethoxyphenyl)-2-glycinamidoethanol

(+/-)-1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol hydrochloride

Prestwick_625

Midodrine Hydrochloride (200 mg)

2-aMino-N-(2-(2,5-diMethoxyphenyl)-2-hydroxyethyl)acetaMide hydrochloride

Midodrine hydrochloride, >=98%

Midodrine Hydrochloride (1443704)

Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-,monohydrochloride, (?±)-

3092-17-9

C12H18N2O4HCl

C12H19ClN2O4

METI - MZ

Analytical Standards

Analytical Chromatography Product Catalog

Alphabetic

API

Intermediates & Fine Chemicals

Pharmaceuticals

Isotopically Labeled Pharmaceutical Reference Standard

VIVITROL