Midodrine hydrochloride

ChemicalBook > CAS DataBase List > Midodrine hydrochloride

Midodrine hydrochloride

Product Name: Midodrine hydrochloride
CAS No.: 3092-17-9
Chemical Name: Midodrine hydrochloride
Synonyms: GUTRON;AMATINE;ST-1085;HIPERTAN;MIDODRINE;METLIGINE;PROAMATINE;MIDODRINE HCL;Prestwick_625;MIDODRINE HYDROCHLORIDE
CBNumber: CB6117144
Molecular Formula: C12H19ClN2O4
Formula Weight: 290.74
MOL File: 3092-17-9.mol

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Midodrine hydrochloride Property

Melting point:: 192-193°C
storage temp.: -20°C Freezer
InChIKey: MGCQZNBCJBRZDT-UHFFFAOYSA-N
CAS DataBase Reference: 3092-17-9(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: AB4343000
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M8277
Product name: Midodrine hydrochloride
Purity: analytical standard, for drug analysis
Packaging: 1g
Price: $377
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1443704
Product name: Midodrine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: M8277
Product name: Midodrine hydrochloride
Purity: analytical standard, for drug analysis
Packaging: 50mg
Price: $114
Updated: 2024/03/01

Usbiological

Product number: M3895-06K
Product name: Midodrine, Hydrochloride
Packaging: 10mg
Price: $403
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0024416
Product name: MIDODRINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $418
Updated: 2021/12/16

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Midodrine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Gutron,Hormonchemie,W. Germany,1977

Uses

morphine antagonist

Uses

A phenylalkanolamine derivative which has been found to be effective in treating hypertensive conditions due to their long lasting blood pressure increasing effects

Definition

ChEBI: A hydrochloride resulting from the combination of equimolar amounts of midodrine and hydrogen chloride. Midodrine is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. The hydrochloride salt is used as a periph ral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Manufacturing Process

19.5 parts of carbobenzoxyglycine, 7.1 parts of triethylamine and 162 parts ofdry toluene are mixed with 11.2 parts of isovaleric acid chloride at 0°C toform the mixed anhydride and the mixture is agitated for two hours at 0°C.32.4 parts of 1-(2',5'-dimethoxyphenyl)-2-aminoethanol-(1) are then added,the mixture is agitated for four hours at a temperature between 0°C and+10°C and then left to stand overnight at that temperature. A thick crystalpaste forms. The reaction product is dissolved in 450 parts of ethyl acetateand 200 parts of water. The ethyl acetate solution is separated, washed withhydrochloric acid, sodium bicarbonate solution and water, dried over sodiumsulfate and inspissated. The inspissation residue is digested with 342 parts ofxylene, the required product crystallizing out. 34.9 parts of 1-(2',5'-dimethoxyphenyl)-2-(N-carbobenzoxyglycineamido)-ethanol-(1) are obtained.66.2 parts of 1-(2',5'-dimethoxyphenyl)-2-(N-carbobenzoxyglycineamido)-ethanol-(1) are hydrogenated in the presence of 6.6 parts of palladium carbon(10%) in 2,000 parts of glacial acetic acid. When no more hydrogen isabsorbed (3 mols of hydrogen are used), hydrogenation stops. The catalyst isremoved by suction and the equivalent quantity of hydrochloric acid in ethanolis added to the filtrate with agitation. During further agitation at roomtemperature 28.6 parts of crude 1-(2',5'-dimethoxyphenyl)-2-glycineamidoethanol-(1)hydrochloride crystallize, and are isolated andrecrystallized from water-methanol for purification. 22.1 parts of pure productare obtained with a melting point of 192°C to 193°C.
An alternative synthesis route is described by Kleeman and Engel.

brand name

Orvaten (UpsherSmith); Proamatine (Shire).

Therapeutic Function

Peripheral vasotonic, Antihypotensive

General Description

Midodrine is the N-glycyl prodrug ofthe selectiveα1-agonist desglymidodrine. Removal of theN-glycyl moiety from midodrine occurs readily in the liver aswell as throughout the body, presumably by amidases.Midodrine is orally active and represents another example ofa dimethoxy-β-phenylethylamine derivative that is used therapeuticallyfor its vasoconstrictor properties. Specifically, it isused in the treatment of symptomatic orthostatic hypotension.

Clinical Use

Treatment of orthostatic hypotension, including dialysis related hypotension

Drug interactions

Potentially hazardous interactions with other drugs
Adrenergic neurone blockers: midodrine antagonises hypotensive effect.
Anaesthetics: risk of arrhythmias if given with volatile anaesthetics.
Antidepressants: risk of arrhythmias and hypertension if given with tricyclic antidepressants, MAOIs and moclobemide.
Antihypertensives: antagonise hypertensive effect of midodrine; risk of severe hypertension if given with beta-blockers.
Dopaminergics: avoid with rasagiline and selegiline.
Other drugs which increase blood pressure: enhanced hypertensive effect.

Metabolism

Undergoes enzymatic hydrolysis in the systemic circulation to an active metabolite (desglymidodrine)

Midodrine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Midodrine hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Midodrine hydrochloride 3092-17-9
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 2000tons
Release date: 2019-12-31

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Midodrine hydrochloride 3092-17-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-03

Zhuozhou Wenxi import and Export Co., Ltd

Product: Midodrine hydrochloride 3092-17-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

3092-17-9, Midodrine hydrochlorideRelated Search:

N,N-Dimethylacetamide Acetaminophen Methoxydiethylborane Diphenyldiethoxysilane Acetamide Doxycycline hydrochloride Ritodrine hydrochloride 2-Ethylphenylhydrazine hydrochloride Topotecan hydrochloride 4-Methoxyphenylacetone Difenidol hydrochloride Thioacetamide Minocycline hydrochloride (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride Mianserin hydrochloride Hydrochloric acid MIDODRINE MIDODRINE-D6 HCL

[+/-]-1-[2,5-DIMETHOXYPHENYL]-2-GLYCINAMIDOETHANOL HYDROCHLORIDE

AMATINE

METLIGINE

HIPERTAN

GUTRON

2-amino-n-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-acetamidmonohydrochlo

acetamide,2-amino-n-(beta-hydroxy-2,5-dimethoxyphenethyl)-,monohydrochloride,

PROAMATINE

MIDODRINE HCL

MIDODRINE HYDROCHLORIDE

MIDODRINE

ST-1085

ST-1085, Amatine, Gutron, Hipertan, Metligine, ProAmatine,

(±)-1-(2,5-dimethoxyphenyl)-2-glycinamidoethanol

(+/-)-1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol hydrochloride

Prestwick_625

Midodrine Hydrochloride (200 mg)

2-aMino-N-(2-(2,5-diMethoxyphenyl)-2-hydroxyethyl)acetaMide hydrochloride

Midodrine hydrochloride, >=98%

Midodrine Hydrochloride (1443704)

Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-,monohydrochloride, (?±)-

3092-17-9

C12H18N2O4HCl

C12H19ClN2O4

METI - MZ

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