Lerisetron

Product Name: Lerisetron
CAS No.: 143257-98-1
Chemical Name: Lerisetron
Synonyms: CID 65997;F-0930-RS;Lerisetron;Lerisetron, 10 mM in DMSO;1-benzyl-2-piperazin-1-ylbenzimidazole;1-BENZYL-2-PIPERAZIN-1-YL-1H-BENZIMIDAZOLE;1-Benzyl-2-(piperazin-1-yl)-1H-1,3-benzodiazole;1-Benzyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole;1H-Benzimidazole, 1-(phenylmethyl)-2-(1-piperazinyl)-;1-benzyl-2-piperazin-1-yl-1H-benzimidazole dihydrochloride
CBNumber: CB61179015
Molecular Formula: C18H20N4
Formula Weight: 292.38
MOL File: 143257-98-1.mol

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Lerisetron Property

storage temp.: Store at -20°C
solubility: DMSO: 58 mg/mL (198.37 mM);Ethanol: 58 mg/mL (198.37 mM)
form: Solid
color: White to off-white
Water Solubility: Water: Insoluble

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0009131
Product name: LERISETRON
Purity: 95.00%
Packaging: 5MG
Price: $500.83
Updated: 2021/12/16

Matrix Scientific

Product number: 137090
Product name: 1-Benzyl-2-piperazin-1-yl-1H-benzimidazole dihydrochloride
Purity: 95%
Packaging: 1g
Price: $611
Updated: 2021/12/16

AK Scientific

Product number: 3845CA
Product name: Lerisetron
Packaging: 100mg
Price: $623
Updated: 2021/12/16

Matrix Scientific

Product number: 137090
Product name: 1-Benzyl-2-piperazin-1-yl-1H-benzimidazole dihydrochloride
Purity: 95%
Packaging: 2.500g
Price: $1334
Updated: 2021/12/16

AK Scientific

Product number: 3845CA
Product name: Lerisetron
Packaging: 5g
Price: $1724
Updated: 2021/12/16

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Lerisetron Chemical Properties,Usage,Production

Uses

Lerisetron is a potent 5-HT3 antagonists and possess high-affinity binding for the 5-HT3 receptors with pKi value of 9.2. Lerisetron has a potent ability to inhibit the 5-HT-evoked reflex bradycardia in urethane-anesthetized rats[1].

in vivo

Lerisetron (50-200 μg/kg; IV; single) exhibits CL of 0.004-0.005 L/min, Vd_s of 0.88-0.96 L, MRT_0-LAST of 224-337.1 min and AUC_∞ of 57.7-66.1 μg·min/L in rats^[2].
Lerisetron (2-10 μg/kg; IV; single) causes rapid recovery from bradycardia^[2].
Pharmacokinetic Parameters of Lerisetron in Sprague-Dawley rats^[2].

	IV (50 μg/kg)	IV (100 μg/kg)	IV (200 μg/kg)
CL (L/min)	0.005	0.004	0.004
Vd_s (L)	0.9	0.88	0.96
MRT_0-LAST (min)	224	337.1	226.3
AUC_∞ (μg·min/L)	66.1	57.7	58.1

References

[1] Orjales A, Mosquera R, Labeaga L, Rodes R. New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation. J Med Chem. 1997;40(4):586-593.
[2] Jauregizar N, Calvo R, Suarez E, Quintana A, Raczka E, Lukas JC. Pharmacokinetics and pharmacological effect of lerisetron, a new 5-HT3 antagonist, in rats. J Pharm Sci. 2002;91(1):41-52. DOI:10.1002/jps.1169

Lerisetron Preparation Products And Raw materials

Raw materials

Preparation Products

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Lerisetron Suppliers

China 24 United States 4 Global 28

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143257-98-1, LerisetronRelated Search:

ONDANSETRON FOR LC SYSTEM SUITABILITY Palonosetron ALOSETRON dolasetron Dolasetron mesylate Granisetron Palonosetron Hydrochloride Palonosetron 1-(4-FLUORO-BENZYL)-2-PIPERAZIN-1-YL-1H-BENZOIMIDAZOLE 1-BENZYL-2-(4-BENZYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOLE Lerisetron 1-BENZYL-2-(4-METHYL-PIPERAZIN-1-YL)-1H-BENZOIMIDAZOLE ZERENEX EZX001545 1-BENZYL-2-(4-PHENYL-PIPERAZIN-1-YL)-1H-BENZOIMIDAZOLE

1-benzyl-2-piperazin-1-ylbenzimidazole

F-0930-RS

Lerisetron

1-benzyl-2-piperazin-1-yl-1H-benzimidazole dihydrochloride

1-BENZYL-2-PIPERAZIN-1-YL-1H-BENZIMIDAZOLE

CID 65997

1H-Benzimidazole, 1-(phenylmethyl)-2-(1-piperazinyl)-

5-HT Receptor,Serotonin Receptor,Serotonin,Lerisetron,Bradycardia,Inhibitor,5-hydroxytryptamine Receptor,Pharmacokinetics,inhibit,SD rats

1-Benzyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole

Lerisetron, 10 mM in DMSO

1-Benzyl-2-(piperazin-1-yl)-1H-1,3-benzodiazole

143257-98-1

C18H22Cl2N4