dolasetron

Product Name: dolasetron
CAS No.: 115956-12-2
Chemical Name: dolasetron
Synonyms: Hsdb 7565;DOLASETRON;Dolasteron;Dolasetronum;Unii-82wi2L7Q6e;dolasetron USP/EP/BP;Dolasetronum [inn-latin];Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester;3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-Indole-3-carboxylate;1H-Indole-3-carboxylic Acid 3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl Ester
CBNumber: CB12130500
Molecular Formula: C19H20N2O3
Formula Weight: 324.37
MOL File: 115956-12-2.mol

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dolasetron Property

Melting point:: 278 ºC
Boiling point:: 535.1±50.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
pka: 15.36±0.30(Predicted)
form: Solid
color: White
Water Solubility: Soluble
CAS DataBase Reference: 115956-12-2

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Safety

Hazardous Substances Data: 115956-12-2(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22234
Product name: Dolasetron
Purity: ≥98%
Packaging: 5mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 22234
Product name: Dolasetron
Purity: ≥98%
Packaging: 10mg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 22234
Product name: Dolasetron
Purity: ≥98%
Packaging: 25mg
Price: $179
Updated: 2024/03/01

Cayman Chemical

Product number: 22234
Product name: Dolasetron
Purity: ≥98%
Packaging: 50mg
Price: $333
Updated: 2024/03/01

ChemScene

Product number: CS-3747
Product name: Dolasetron
Purity: >98.0%
Packaging: 10mg
Price: $192
Updated: 2021/12/16

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dolasetron Chemical Properties,Usage,Production

Description

Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT₃ (K_i = 20 nM). It is selective for 5-HT₃ receptors over 5-HT_1A, 5-HT_1B, 5-HT₂, dopamine D₂, α₁-, α₂-, β-adrenergic, M_1-5 muscarinic acetylcholine, and neurokinin-1 (NK₁) receptors (IC₅₀s = >10 μM for all). Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC₅₀ = 3.8 nM). It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin in ferrets when administered at doses of 0.5 or 2 mg/kg. Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.

Chemical Properties

White Solid

Uses

prevention and treatment of postoperative nausea and vomiting

Uses

Dolasetron is a bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist.It is used as antiemetic.

Uses

Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.

Definition

ChEBI: LSM-5418 is an indolyl carboxylic acid.

brand name

Anzemet (Sanofi Aventis.

dolasetron Preparation Products And Raw materials

Raw materials

Preparation Products

Suprofen

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dolasetron Suppliers

Americas 1 Canada 1 China 81 Europe 1 India 4 Japan 1 United States 10 Global 99

Sangel Pharmaceutical & Chemical Factory

Tel: 0571-0571-85773987 13505717485
Fax: +86057185773986
Email: 1610413282@qq.com
Country: China
ProdList: 70
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9984
Advantage: 60

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2893
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9442
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

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View Lastest Price from dolasetron manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Dolasetron 115956-12-2
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2022-02-15

Zhuozhou Wenxi import and Export Co., Ltd

Product: Dolasetron 115956-12-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Dolasetron 115956-12-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

115956-12-2, dolasetronRelated Search:

Olanzapine DROPERIDOL PENTAZOCINE Dexmedetomidine Omeprazole Ramosetron hydrochloride 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide Azasetron hydrochloride Dolasetron mesylate 1-ISOPROPYL-3-PIPERIDINONE (2a,6a,8a,9ab)-Hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one 3-QUINUCLIDINONE CHEMBRDG-BB 4015185 1-(2-methylpiperidin-1-yl)acetone 2-CYCLOOCTYL-ETHYLAMINE 1-piperidinoacetone dolasetron Hexahydro-8-Hydroxy-2, 6-Methano-2h-Quinolizin-3(4h)-One

(2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate

Dolasteron

Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester

1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2alpha,6alpha,8alpha,9abeta)-

Dolasetronum

Dolasetronum [inn-latin]

Hsdb 7565

Unii-82wi2L7Q6e

(2a,6a,8a,9ab)-1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester

1H-Indole-3-carboxylicacid, octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl ester, stereoisoMer

DOLASETRON

1H-Indole-3-carboxylic Acid 3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl Ester

3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-Indole-3-carboxylate

dolasetron USP/EP/BP

rel-(5s,6R,8r,9aS)-3-Oxooctahydro-1H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate

115956-12-2

API

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals