dolasetron
- Product Name
- dolasetron
- CAS No.
- 115956-12-2
- Chemical Name
- dolasetron
- Synonyms
- Hsdb 7565;DOLASETRON;Dolasteron;Dorasetron;Dolasetronum;Unii-82wi2L7Q6e;dolasetron USP/EP/BP;Dolasetronum [inn-latin];Dolasetron, 10 mM in DMSO;Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester
- CBNumber
- CB12130500
- Molecular Formula
- C19H20N2O3
- Formula Weight
- 324.37
- MOL File
- 115956-12-2.mol
dolasetron Property
- Melting point:
- 278 ºC
- Boiling point:
- 535.1±50.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
- pka
- 15.36±0.30(Predicted)
- form
- Solid
- color
- White
- Water Solubility
- Soluble
- CAS DataBase Reference
- 115956-12-2
Safety
- Hazardous Substances Data
- 115956-12-2(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D5820
- Product name
- Dolasetron
- Packaging
- 10MG
- Price
- $110
- Updated
- 2026/03/19
- Product number
- D5820
- Product name
- Dolasetron
- Packaging
- 50MG
- Price
- $332
- Updated
- 2026/03/19
- Product number
- 22234
- Product name
- Dolasetron
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 22234
- Product name
- Dolasetron
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $77
- Updated
- 2024/03/01
- Product number
- 22234
- Product name
- Dolasetron
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $179
- Updated
- 2024/03/01
dolasetron Chemical Properties,Usage,Production
Description
Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 20 nM). It is selective for 5-HT3 receptors over 5-HT1A, 5-HT1B, 5-HT2, dopamine D2, α1-, α2-, β-adrenergic, M1-5 muscarinic acetylcholine, and neurokinin-1 (NK1) receptors (IC50s = >10 μM for all). Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC50 = 3.8 nM). It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin in ferrets when administered at doses of 0.5 or 2 mg/kg. Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.
Chemical Properties
White Solid
Uses
prevention and treatment of postoperative nausea and vomiting
Uses
Dolasetron is a bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist.It is used as antiemetic.
Uses
Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.
Definition
ChEBI: LSM-5418 is an indolyl carboxylic acid.
brand name
Anzemet (Sanofi Aventis.
Synthesis
Ethyl cyclopentenecarboxylate (I), in the presence of a catalytic amount of osmium tetroxide, was oxidized to diol (II) with N-methylmorpholine-N-oxide. It was then split to dialdehyde (III) in the presence of sodium periodate and its aqueous solution was converted to bicyclization (IV) at pH 4 by Robinson-Schoepf reaction. (IV) was then reduced to alcohol (V) with sodium borohydride and reacted with dihydropyran to form tetrahydrofuran ether (VI) to protect the hydroxyl group formed. This is then converted to the tricyclic compound (VII), which is then acylated to give dolasetron by reacting with an acyl chloride (VIII) in the presence of silver tetrafluoroborate.
References
[1] PETER H. BOEIJINGA . Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma × glioma cells[J]. European journal of pharmacology, 1992, 219 1: Pages 9-13. DOI: 10.1016/0014-2999(92)90573-m
[2] ROBERT C. MILLER. Pharmacological properties of dolasetron, a potent and selective antagonist at 5-HT3 receptors[J]. Drug Development Research, 1993, 28 1: 87-93. DOI: 10.1002/ddr.430280111
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View Lastest Price from dolasetron manufacturers
- Product
- Dolasetron 115956-12-2
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 1000g
- Release date
- 2022-02-15
- Product
- Dolasetron 115956-12-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Dolasetron 115956-12-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08