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dolasetron

Product Name
dolasetron
CAS No.
115956-12-2
Chemical Name
dolasetron
Synonyms
Hsdb 7565;DOLASETRON;Dolasteron;Dorasetron;Dolasetronum;Unii-82wi2L7Q6e;dolasetron USP/EP/BP;Dolasetronum [inn-latin];Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester;3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-Indole-3-carboxylate
CBNumber
CB12130500
Molecular Formula
C19H20N2O3
Formula Weight
324.37
MOL File
115956-12-2.mol
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dolasetron Property

Melting point:
278 ºC
Boiling point:
535.1±50.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
pka
15.36±0.30(Predicted)
form 
Solid
color 
White
Water Solubility 
Soluble
CAS DataBase Reference
115956-12-2
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Safety

Hazardous Substances Data
115956-12-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22234
Product name
Dolasetron
Purity
≥98%
Packaging
5mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
22234
Product name
Dolasetron
Purity
≥98%
Packaging
10mg
Price
$77
Updated
2024/03/01
Cayman Chemical
Product number
22234
Product name
Dolasetron
Purity
≥98%
Packaging
25mg
Price
$179
Updated
2024/03/01
Cayman Chemical
Product number
22234
Product name
Dolasetron
Purity
≥98%
Packaging
50mg
Price
$333
Updated
2024/03/01
ChemScene
Product number
CS-3747
Product name
Dolasetron
Purity
>98.0%
Packaging
10mg
Price
$192
Updated
2021/12/16
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dolasetron Chemical Properties,Usage,Production

Description

Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 20 nM). It is selective for 5-HT3 receptors over 5-HT1A, 5-HT1B, 5-HT2, dopamine D2, α1-, α2-, β-adrenergic, M1-5 muscarinic acetylcholine, and neurokinin-1 (NK1) receptors (IC50s = >10 μM for all). Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC50 = 3.8 nM). It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin in ferrets when administered at doses of 0.5 or 2 mg/kg. Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.

Chemical Properties

White Solid

Uses

prevention and treatment of postoperative nausea and vomiting

Uses

Dolasetron is a bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist.It is used as antiemetic.

Uses

Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.

Definition

ChEBI: LSM-5418 is an indolyl carboxylic acid.

brand name

Anzemet (Sanofi Aventis.

dolasetron Preparation Products And Raw materials

Raw materials

Preparation Products

Suprofen
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dolasetron Suppliers

Americas 1 Canada 1 China 81 Europe 1 India 4 Japan 1 United States 11 Global 100
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from dolasetron manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Dolasetron 115956-12-2
Price
US $0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
1000g
Release date
2022-02-15
Zhuozhou Wenxi import and Export Co., Ltd
Product
Dolasetron 115956-12-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Dolasetron 115956-12-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

115956-12-2, dolasetronRelated Search:

Olanzapine DROPERIDOL PENTAZOCINE Dexmedetomidine Omeprazole Ramosetron hydrochloride 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide Azasetron hydrochloride Dolasetron mesylate 1-ISOPROPYL-3-PIPERIDINONE (2a,6a,8a,9ab)-Hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one 3-QUINUCLIDINONE CHEMBRDG-BB 4015185 1-(2-methylpiperidin-1-yl)acetone 2-CYCLOOCTYL-ETHYLAMINE 1-piperidinoacetone dolasetron Hexahydro-8-Hydroxy-2, 6-Methano-2h-Quinolizin-3(4h)-One

  • (2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate
  • Dolasteron
  • Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester
  • 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2alpha,6alpha,8alpha,9abeta)-
  • Dolasetronum
  • Dolasetronum [inn-latin]
  • Hsdb 7565
  • Unii-82wi2L7Q6e
  • (2a,6a,8a,9ab)-1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester
  • 1H-Indole-3-carboxylicacid, octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl ester, stereoisoMer
  • DOLASETRON
  • 1H-Indole-3-carboxylic Acid 3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl Ester
  • 3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-Indole-3-carboxylate
  • dolasetron USP/EP/BP
  • rel-(5s,6R,8r,9aS)-3-Oxooctahydro-1H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate
  • Dorasetron
  • 115956-12-2
  • API
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals