dolasetron
- Product Name
- dolasetron
- CAS No.
- 115956-12-2
- Chemical Name
- dolasetron
- Synonyms
- Hsdb 7565;DOLASETRON;Dolasteron;Dolasetronum;Unii-82wi2L7Q6e;dolasetron USP/EP/BP;Dolasetronum [inn-latin];Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester;3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-Indole-3-carboxylate;1H-Indole-3-carboxylic Acid 3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl Ester
- CBNumber
- CB12130500
- Molecular Formula
- C19H20N2O3
- Formula Weight
- 324.37
- MOL File
- 115956-12-2.mol
dolasetron Property
- Melting point:
- 278 ºC
- Boiling point:
- 535.1±50.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
- pka
- 15.36±0.30(Predicted)
- form
- Solid
- color
- White
- Water Solubility
- Soluble
- CAS DataBase Reference
- 115956-12-2
Safety
- Hazardous Substances Data
- 115956-12-2(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 22234
- Product name
- Dolasetron
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 22234
- Product name
- Dolasetron
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $77
- Updated
- 2024/03/01
- Product number
- 22234
- Product name
- Dolasetron
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- 22234
- Product name
- Dolasetron
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $333
- Updated
- 2024/03/01
- Product number
- CS-3747
- Product name
- Dolasetron
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $192
- Updated
- 2021/12/16
dolasetron Chemical Properties,Usage,Production
Description
Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 20 nM). It is selective for 5-HT3 receptors over 5-HT1A, 5-HT1B, 5-HT2, dopamine D2, α1-, α2-, β-adrenergic, M1-5 muscarinic acetylcholine, and neurokinin-1 (NK1) receptors (IC50s = >10 μM for all). Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC50 = 3.8 nM). It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin in ferrets when administered at doses of 0.5 or 2 mg/kg. Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.
Chemical Properties
White Solid
Uses
prevention and treatment of postoperative nausea and vomiting
Uses
Dolasetron is a bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist.It is used as antiemetic.
Uses
Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.
Definition
ChEBI: LSM-5418 is an indolyl carboxylic acid.
brand name
Anzemet (Sanofi Aventis.
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View Lastest Price from dolasetron manufacturers
- Product
- Dolasetron 115956-12-2
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 1000g
- Release date
- 2022-02-15
- Product
- Dolasetron 115956-12-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Dolasetron 115956-12-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08