ChemicalBook > CAS DataBase List > Pimonidazole

Pimonidazole

Product Name: Pimonidazole
CAS No.: 70132-50-2
Chemical Name: Pimonidazole
Synonyms: NSC 380540;Pimonidazole;Pimonidazole USP/EP/BP;inhibit,Pimonidazole,Inhibitor;1-(2-nitroimidazol-1-yl)-3-piperidin-1-ylpropan-2-ol;alpha-((2-Nitroimidazol-1-yl)methyl)-1-piperidineethanol;α-[(2-Nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol;1-(2-Nitro-1H-imidazol-1-yl)-3-(piperidin-1-yl)propan-2-ol;1-Piperidineethanol, α-[(2-nitro-1H-imidazol-1-yl)methyl]-;1-(2-Nitro-1H-imidazol-1-yl)-3-(piperidin-1-yl)-2-propanol
CBNumber: CB61179505
Molecular Formula: C11H18N4O3
Formula Weight: 254.29
MOL File: 70132-50-2.mol

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Pimonidazole Property

Melting point:: 110-113°C
Boiling point:: 490.5±55.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >20mg/mL
pka: 14.06±0.20(Predicted)
form: powder
color: yellow

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Safety

Hazard Codes: Xn
Risk Statements: 22

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N1165
Product name: Pimonidazole
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $164.35
Updated: 2025/07/31

Sigma-Aldrich

Product number: N1165
Product name: Pimonidazole
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $485.8
Updated: 2025/07/31

Cayman Chemical

Product number: 89130
Product name: Pimonidazole
Purity: ≥98%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 89130
Product name: Pimonidazole
Purity: ≥98%
Packaging: 10mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 89130
Product name: Pimonidazole
Purity: ≥98%
Packaging: 50mg
Price: $243
Updated: 2024/03/01

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Pimonidazole Chemical Properties,Usage,Production

Description

Hypoxic cells are low oxygen cells that when present in tumors are radioresistant and chemoresistant. Pimonidazole is a small molecule radiosensitizer that has proven to be an effective and nontoxic hypoxia marker for human squamous cell carcinomas of the cervix, head, and neck. This immunochemical hypoxia marker has been widely used in experimental and clinical studies due to its chemical stability, water solubility, and wide tissue distribution. It is generally administered in aqueous solution by injection.

Uses

Pimonidazole is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It labels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.

Biochem/physiol Actions

Pimonidazole is an effective and nontoxic exogenous 2-nitroimidazole hypoxia marker. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids.

storage

Store at -20°C

References

[1] JOHANNES H A M KAANDERS. Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.[J]. Cancer research, 2002, 62 23: 7066-7074.

Pimonidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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70132-50-2, PimonidazoleRelated Search:

B16 cell tert-Butyl carbamate 1-methyl-2-nitrosoimidazole 1-methyl-2-nitroimidazole 2-nitro-1H-imidazole Pimonidazole

Pimonidazole

1-(2-Nitro-1H-imidazol-1-yl)-3-(piperidin-1-yl)-2-propanol

α-[(2-Nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol

alpha-((2-Nitroimidazol-1-yl)methyl)-1-piperidineethanol

alpha-[(2-Nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol

NSC 380540

1-(2-nitroimidazol-1-yl)-3-piperidin-1-ylpropan-2-ol

1-Piperidineethanol, α-[(2-nitro-1H-imidazol-1-yl)methyl]-

Pimonidazole USP/EP/BP

inhibit,Pimonidazole,Inhibitor

1-(2-Nitro-1H-imidazol-1-yl)-3-(piperidin-1-yl)propan-2-ol

70132-50-2