Tolimidone

ChemicalBook > CAS DataBase List > Tolimidone

Product Name: Tolimidone
CAS No.: 41964-07-2
Chemical Name: Tolimidone
Synonyms: MLR 1023;100568;CP-26154;CID-39065;NSC 314335;Tolimidone;Tolimidone (MLR-1023);MLR 1023 - Tolimidone | CP 26154;5-(m-Tolyloxy)pyrimidin-2(1H)-one;5-(3-Methylphenoxy)-2(1H)-pyrimidinone
CBNumber: CB61179954
Molecular Formula: C11H10N2O2
Formula Weight: 202.21
MOL File: 41964-07-2.mol

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Tolimidone Property

Melting point:: 163-164℃
Density: 1.22
storage temp.: room temp
solubility: DMSO: soluble15mg/mL (clear solution)
form: powder
pka: 8.14±0.10(Predicted)
color: white to beige

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0371
Product name: MLR-1023
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $97.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0371
Product name: MLR-1023
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $380
Updated: 2024/03/01

Cayman Chemical

Product number: 21496
Product name: MLR-1023
Purity: ≥95%
Packaging: 5mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 21496
Product name: MLR-1023
Purity: ≥95%
Packaging: 10mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 21496
Product name: MLR-1023
Purity: ≥95%
Packaging: 25mg
Price: $209
Updated: 2024/03/01

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Tolimidone Chemical Properties,Usage,Production

Description

MLR-1023 is an allosteric activator of Lyn kinase (EC₅₀ = 63 nM). It has no significant activity against a panel of related kinases. MLR-1023 is orally bioavailable and reduces blood glucose levels in mice subjected to an oral glucose tolerance test. This effect is insulin-dependent, with MLR-1023 increasing insulin receptor sensitivity. MLR-1023 produces a dose-dependent and durable glucose-lowering effect in chronically treated db/db mice without causing weight gain.

Uses

Tolimidone (MLR-1023) is an allosteric Lyn kinase activator that has been shown to reduce blood glucose levels in mice. Studies show that Tolimidone is an effective insulin receptor-potentiating agent that is potentially capable of producing durable blood glucose-lowering activity in diabetics. Tolimidone is a candidate for the treatment of type 2 diabetes.

storage

Store at +4°C

Tolimidone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tolimidone manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Tolimidone 41964-07-2
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-24

Shaanxi Dideu Medichem Co. Ltd

Product: Tolimidone 41964-07-2
Price: US $1.00-1.00/KG
Min. Order: 1KG
Purity: 99%+
Supply Ability: 100 tons
Release date: 2019-12-26

Shaanxi Dideu Medichem Co. Ltd

Product: Tolimidone 41964-07-2
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2020-01-14

41964-07-2, TolimidoneRelated Search:

Mifepristone Tolimidone 2(1H)-Pyrimidinone, 5-methoxy- (9CI)

Tolimidone

5-(m-Tolyloxy)pyrimidin-2(1H)-one

CP-26154

2(1H)-Pyrimidinone, 5-(3-methylphenoxy)-

5-(3-methylphenoxy)-1H-pyrimidin-2-one

5-(3-Methylphenoxy)-2(1H)-pyrimidinone

NSC 314335

MLR 1023

CID-39065

100568

MLR 1023 - Tolimidone | CP 26154

5-(3-Methylphenoxy)-2(1H)-pyrimidinone, 95+%

Tolimidone (MLR-1023)

41964-07-2