Tolimidone
- Product Name
- Tolimidone
- CAS No.
- 41964-07-2
- Chemical Name
- Tolimidone
- Synonyms
- MLR 1023;100568;CP-26154;CID-39065;NSC 314335;Tolimidone;MLR-1023 ，S8321;Tolimidone (MLR-1023);Tolimidone, 10 mM in DMSO;MLR 1023 - Tolimidone | CP 26154
- CBNumber
- CB61179954
- Molecular Formula
- C11H10N2O2
- Formula Weight
- 202.21
- MOL File
- 41964-07-2.mol
Tolimidone Property
- Melting point:
- 163-164℃
- Density
- 1.22
- storage temp.
- room temp
- solubility
- DMSO: soluble15mg/mL (clear solution)
- form
- powder
- pka
- 8.14±0.10(Predicted)
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML0371
- Product name
- MLR-1023
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $101
- Updated
- 2025/07/31
- Product number
- SML0371
- Product name
- MLR-1023
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $371.45
- Updated
- 2025/07/31
- Product number
- 21496
- Product name
- MLR-1023
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 21496
- Product name
- MLR-1023
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 21496
- Product name
- MLR-1023
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $209
- Updated
- 2024/03/01
Tolimidone Chemical Properties,Usage,Production
Description
MLR-1023 is an allosteric activator of Lyn kinase (EC50 = 63 nM). It has no significant activity against a panel of related kinases. MLR-1023 is orally bioavailable and reduces blood glucose levels in mice subjected to an oral glucose tolerance test. This effect is insulin-dependent, with MLR-1023 increasing insulin receptor sensitivity. MLR-1023 produces a dose-dependent and durable glucose-lowering effect in chronically treated db/db mice without causing weight gain.
Uses
Tolimidone (MLR-1023) is an allosteric Lyn kinase activator that has been shown to reduce blood glucose levels in mice. Studies show that Tolimidone is an effective insulin receptor-potentiating agent that is potentially capable of producing durable blood glucose-lowering activity in diabetics. Tolimidone is a candidate for the treatment of type 2 diabetes.
in vivo
Administration of Tolimidone (MLR-1023) (30 mg/kg i.p.) significantly (p<0.05) lowers blood glucose levels to 148 and 158 mg/dL, 30 and 90 min after administration, respectively. Tolimidone significantly increases adipocyte differentiation and adiponectin production by 3.7- and 19-fold, respectively[1]. Tolimidone elicits a dose-dependent potentiation of the insulin response, with a maximal effect observed with a dose level of 30 mg/kg[2].
storage
Store at +4°C
References
[1] MICHAEL S SAPORITO. MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo.[J]. ACS Applied Electronic Materials, 2012: 15-22. DOI: 10.1124/jpet.112.192096
[2] ALEXANDER R OCHMAN. The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes.[J]. Journal of Pharmacology and Experimental Therapeutics, 2012, 342 1: 23-32. DOI: 10.1124/jpet.112.192187
Tolimidone Preparation Products And Raw materials
Raw materials
Preparation Products
Tolimidone Suppliers
- Tel
- +49-7246-3082843
- info@vladachem.de
- Country
- Germany
- ProdList
- 1859
- Advantage
- 58
View Lastest Price from Tolimidone manufacturers
- Product
- Tolimidone 41964-07-2
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-24
- Product
- Tolimidone 41964-07-2
- Price
- US $1.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%+
- Supply Ability
- 100 tons
- Release date
- 2019-12-26
- Product
- Tolimidone 41964-07-2
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-14