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Tolimidone

Product Name
Tolimidone
CAS No.
41964-07-2
Chemical Name
Tolimidone
Synonyms
MLR 1023;100568;CP-26154;CID-39065;NSC 314335;Tolimidone;Tolimidone (MLR-1023);MLR 1023 - Tolimidone | CP 26154;5-(m-Tolyloxy)pyrimidin-2(1H)-one;5-(3-Methylphenoxy)-2(1H)-pyrimidinone
CBNumber
CB61179954
Molecular Formula
C11H10N2O2
Formula Weight
202.21
MOL File
41964-07-2.mol
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Tolimidone Property

Melting point:
163-164℃
Density 
1.22
storage temp. 
room temp
solubility 
DMSO: soluble15mg/mL (clear solution)
form 
powder
pka
8.14±0.10(Predicted)
color 
white to beige
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0371
Product name
MLR-1023
Purity
≥98% (HPLC)
Packaging
5mg
Price
$97.9
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0371
Product name
MLR-1023
Purity
≥98% (HPLC)
Packaging
25mg
Price
$380
Updated
2024/03/01
Cayman Chemical
Product number
21496
Product name
MLR-1023
Purity
≥95%
Packaging
5mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
21496
Product name
MLR-1023
Purity
≥95%
Packaging
10mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
21496
Product name
MLR-1023
Purity
≥95%
Packaging
25mg
Price
$209
Updated
2024/03/01
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Tolimidone Chemical Properties,Usage,Production

Description

MLR-1023 is an allosteric activator of Lyn kinase (EC50 = 63 nM). It has no significant activity against a panel of related kinases. MLR-1023 is orally bioavailable and reduces blood glucose levels in mice subjected to an oral glucose tolerance test. This effect is insulin-dependent, with MLR-1023 increasing insulin receptor sensitivity. MLR-1023 produces a dose-dependent and durable glucose-lowering effect in chronically treated db/db mice without causing weight gain.

Uses

Tolimidone (MLR-1023) is an allosteric Lyn kinase activator that has been shown to reduce blood glucose levels in mice. Studies show that Tolimidone is an effective insulin receptor-potentiating agent that is potentially capable of producing durable blood glucose-lowering activity in diabetics. Tolimidone is a candidate for the treatment of type 2 diabetes.

storage

Store at +4°C

Tolimidone Preparation Products And Raw materials

Raw materials

Preparation Products

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Tolimidone Suppliers

Canada 1 China 77 Germany 1 India 2 United Kingdom 2 United States 13 Global 96
VladaChem GmbH
Tel
+49-7246-3082843
Email
info@vladachem.de
Country
Germany
ProdList
1860
Advantage
58
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View Lastest Price from Tolimidone manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Tolimidone 41964-07-2
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-24
Shaanxi Dideu Medichem Co. Ltd
Product
Tolimidone 41964-07-2
Price
US $1.00-1.00/KG
Min. Order
1KG
Purity
99%+
Supply Ability
100 tons
Release date
2019-12-26
Shaanxi Dideu Medichem Co. Ltd
Product
Tolimidone 41964-07-2
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
100 tons
Release date
2020-01-14

41964-07-2, TolimidoneRelated Search:

Mifepristone Tolimidone 2(1H)-Pyrimidinone, 5-methoxy- (9CI)

  • Tolimidone
  • 5-(m-Tolyloxy)pyrimidin-2(1H)-one
  • CP-26154
  • 2(1H)-Pyrimidinone, 5-(3-methylphenoxy)-
  • 5-(3-methylphenoxy)-1H-pyrimidin-2-one
  • 5-(3-Methylphenoxy)-2(1H)-pyrimidinone
  • NSC 314335
  • MLR 1023
  • CID-39065
  • 100568
  • MLR 1023 - Tolimidone | CP 26154
  • 5-(3-Methylphenoxy)-2(1H)-pyrimidinone, 95+%
  • Tolimidone (MLR-1023)
  • 41964-07-2