ChemicalBook > CAS DataBase List > Zetidoline

Zetidoline

Product Name
Zetidoline
CAS No.
51940-78-4
Chemical Name
Zetidoline
Synonyms
MDL-308;Zetidoline;1-(3-Chlorophenyl)-3-[2-(3,3-dimethylazetidin-1-yl)ethyl]-2-imidazolidinone;2-Imidazolidinone, 1-(3-chlorophenyl)-3-[2-(3,3-dimethyl-1-azetidinyl)ethyl]-
CBNumber
CB61180095
Molecular Formula
C16H22ClN3O
Formula Weight
307.823
MOL File
51940-78-4.mol
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0012818
Product name
ZETIDOLINE
Purity
95.00%
Packaging
5MG
Price
$502.34
Updated
2021/12/16
More
Less

Zetidoline Chemical Properties,Usage,Production

Originator

MDL 308 ,Dow Chemical

Manufacturing Process

A solution of 5.0 g of 1-(m-chlorophenyl)-2-imidazolidinone in 30 ml of dimethylformamide is added at room temperature to a mixture of 1.5 g of 50% NaH (mineral oil emulsion) in 30 ml of dimethylformamide. The reaction mixture is stirred for 1 h at room temperature and then 4.5 g of 3,3-dimethyl- 1-(2-chloroethyl)azetidine are added. The mixture is stirred again at room temperature for 2 h and then it is heated for 5 h at 80°-85°C. The salts are filtered off and the solvent is removed under vacuum. The residue is taken up with 8 ml of 18% HCl and 16 ml of water and extracted with diethyl ether. The water solution is alkalinized by addition of 15% sodium carbonate and then extracted with diethyl ether. By evaporation of the organic layer a residue is obtained that is triturated in light petroleum. Yield of 1-(m- chlorophenyl)-3-[2-(3,3-dimethylazetidin-1-y1)ethyl]-2-imidazolidinone 7.25 g, melting point 84°-85°C (after recrystallization from hexane).

Therapeutic Function

Antipsychotic, Neuroleptic

Zetidoline Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Zetidoline Suppliers

TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58

51940-78-4, ZetidolineRelated Search:


  • Zetidoline
  • 1-(3-Chlorophenyl)-3-[2-(3,3-dimethylazetidin-1-yl)ethyl]-2-imidazolidinone
  • MDL-308
  • 2-Imidazolidinone, 1-(3-chlorophenyl)-3-[2-(3,3-dimethyl-1-azetidinyl)ethyl]-
  • 51940-78-4