METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE
- Product Name
- METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE
- CAS No.
- 21035-59-6
- Chemical Name
- METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE
- Synonyms
- 2-Pyridinemethanamine, N-methyl-;NSC 63910;Einecs 244-160-1;alpha-Picolylmethylamine;N-Methyl-1-(pyridin-2-yl);methyl(2-pyridylmethyl)amine;N-Methyl-2-pyridinemethanamine;N-Methylpyridine-2-methanamine;2-[(Methylamino)methyl]pyridine;Pyridine, 2-(methylaminomethyl)-
- CBNumber
- CB6118954
- Molecular Formula
- C7H10N2
- Formula Weight
- 122.17
- MOL File
- 21035-59-6.mol
METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE Property
- Melting point:
- 64 °C
- Boiling point:
- 78-80 °C(Press: 10 Torr)
- Density
- 0.994 g/mL at 25 °C
- refractive index
- n20/D1.524
- Flash point:
- 82℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- pK1:2.92(＋2);pK2:8.82(＋1) (30°C)
- form
- liquid
- color
- Colorless
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 709336
- Product name
- 2-[(Methylamino)methyl]pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $102.81
- Updated
- 2025/07/31
- Product number
- 709336
- Product name
- 2-[(Methylamino)methyl]pyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $204.4
- Updated
- 2025/07/31
- Product number
- M285755
- Product name
- 2-[(Methylamino)methyl]pyridine
- Packaging
- 10g
- Price
- $910
- Updated
- 2021/12/16
- Product number
- CHM0076785
- Product name
- N-METHYL-1-(PYRIDIN-2-YL)METHANAMINE DIHYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1127.86
- Updated
- 2021/12/16
- Product number
- 47354
- Product name
- 2-[(Methylamino)methyl]pyridine
- Packaging
- 10g
- Price
- $1325
- Updated
- 2021/12/16
METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE Chemical Properties,Usage,Production
Uses
2-[(Methylamino)methyl]pyridine is used as a reagent in the preparation and structure activity relationship of imidazolopyrimidones as gonadotropin-releasing hormone (GnRH) receptor antagonists.
Synthesis
1121-60-4
21035-59-6
The general procedure for the synthesis of N-methyl-1-pyridine-2-methylamine from pyridine-2-carbaldehyde is as follows: 1. Preparation of 2-(methylaminomethyl)pyridine: 10.7 g (100 mmol) of pyridine-2-carbaldehyde was dissolved in 60 ml of benzene, and methylamine gas was passed through and bubbled for 2 hours. After completion of the reaction, the benzene was removed by distillation under reduced pressure. The residue was dissolved in 40 ml of ethanol. 2. Reduction reaction: Add 5.7g NaBH4 to the above ethanol solution in batches and stir the reaction mixture for 8 hours at room temperature. 3. Post-treatment: 0.5N hydrochloric acid was slowly added to the reaction mixture and the pH was adjusted to not less than 6. Subsequently, 300 ml of dichloromethane was added, and the organic layer was washed three times with 1M NaHCO3 solution at pH 10. 4. Purification of product: The organic layers were combined and concentrated under reduced pressure to give 10.4 g of N-methyl-1-pyridine-2-methylamine in 85% yield. Product characterization: 1H NMR (CDCl3) δ 2.1 (s, 1H), 2.5 (s, 3H), 3.9 (s, 2H), 7.1 (t, 1H), 7.3 (d, 1H), 7.6 (t, 1H), 8.5 (d, 1H).
References
[1] Patent: US5587388, 1996, A
[2] Patent: EP601486, 1994, A1
[3] Magnetic Resonance in Chemistry, 1987, vol. 25, p. 696 - 706
METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE manufacturers
- Product
- METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE 21035-59-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-07-11