TPEN

Product Name: TPEN
CAS No.: 16858-02-9
Chemical Name: TPEN
Synonyms: TPEN;TPEDA;CS-960;TPEN, >=98%;TPEN/CH63857;TPEN ISO 9001：2015 REACH;TPEN - CAS 16858-02-9 - Calbiochem;N,N'-Ethylenebis[bis(2-pyridyl)amine];TETRAKIS-(2-PYRIDYLMETHYL)ETHYLENEDIAMINE;N,N,N',N'-Tetra(2-pyridyl)-1,2-ethanediamine
CBNumber: CB1249909
Molecular Formula: C26H28N6
Formula Weight: 424.54
MOL File: 16858-02-9.mol

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TPEN Property

Melting point:: 110-112 °C
Boiling point:: 530.56°C (rough estimate)
Density: 1.3893 (rough estimate)
refractive index: 1.4570 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in DMSO (up to 10 mg/ml).
pka: 5.19±0.12(Predicted)
form: Tan solid
color: Off-white or tan
BRN: 4211982
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 16858-02-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 8-10-23
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P4413
Product name: N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine
Packaging: 50mg
Price: $100
Updated: 2024/03/01

Sigma-Aldrich

Product number: P4413
Product name: N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine
Packaging: 100mg
Price: $148
Updated: 2024/03/01

Sigma-Aldrich

Product number: 616394
Product name: TPEN - CAS 16858-02-9 - Calbiochem
Packaging: 100mg
Price: $192
Updated: 2024/03/01

TCI Chemical

Product number: T1487
Product name: N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine
Purity: >97.0%(T)
Packaging: 1g
Price: $213
Updated: 2024/03/01

TCI Chemical

Product number: T1487
Product name: N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine
Purity: >97.0%(T)
Packaging: 5g
Price: $722
Updated: 2024/03/01

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TPEN Chemical Properties,Usage,Production

Description

TPEN (16858-02-9) is a cell permeable metal chelator. Frequently used to study effects of zinc depletion on cellular processes.1,2

Chemical Properties

Colourless Crystals

Uses

Membrane-permeable zinc chelator; decreased the intracellular level of zinc and induced apoptosis.

Definition

ChEBI: An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.

Biochem/physiol Actions

N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) elicits pro-apoptotic effect in human acute promyelocytic NB4 cells by inhibiting nitric oxide signalling and Zn2+ signaling. In microglia pretreated with zinc, TPEN inhibits the interleukin 6 secretion and nitric oxide synthase (iNOS) mRNA expression. It induces damage on DNA structure by activating ATM (ataxia telangiectasia mutated) and ATR (ATM-Rad3-related) signaling in human colon cancer cells.

storage

Store at +4°C

References

1) Chimienti et al. (2001) Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases and cleavage of Sp family transcription factors; Biochem. Pharmacol. 62 51 2) Meplan et al. (2000) Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells; Oncogene 19 5227

TPEN Preparation Products And Raw materials

Raw materials

Preparation Products

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TPEN Suppliers

Canada 1 China 115 Europe 2 Germany 2 India 5 Japan 2 Switzerland 2 United Kingdom 2 United States 24 Global 155

Hubei Jingli Chemistry Co., Ltd.

Tel: 15926669505
Email: jinglichemistry@126.com
Country: China
ProdList: 152
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 8418
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

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View Lastest Price from TPEN manufacturers

Dideu Industries Group Limited

Product: TPEN 16858-02-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-27

Zhuozhou Wenxi import and Export Co., Ltd

Product: TPEN 16858-02-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: TPEN 16858-02-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-25

16858-02-9, TPENRelated Search:

Bleomycin sulfate Idebenone Eltrombopag Deferiprone 2-Aminoethyl(ethyl)amine Zinc sulfate monohydrate N,N'-BIS-2-PYRIDYLMETHYL ETHYLENEDIAMINE TPEN 2,2'-DIPICOLYLAMINE 2-Picolylamine METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE CHEMBRDG-BB 9070750

N,N,N',N'-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE

TETRAKIS-(2-PYRIDYLMETHYL)ETHYLENEDIAMINE

{2-[BIS(PYRIDIN-2-YLMETHYL)AMINO]ETHYL}BIS(PYRIDIN-2-YLMETHYL)AMINE

TPEN - CAS 16858-02-9 - Calbiochem

N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-Ethanediamine

CS-960

TPEN

1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)-

1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)-, (oc-6-11)-

N1,N1,N2,N2-tetrakis(pyridin-2-ylMethyl)ethane-1,2-diaMine

N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine

N,N,N',N',-TETRAKIS(2-PYRIDYLMETHYL)*ETH YLENEDIAMIN

TPEN/CH63857

N,N,NNTetrakis(2-pyridylmethyl)-1,2-ethylenediamine

N,N,NNTetrakis-pyridin-2-ylmethyl-ethane-1,2-diamine

N,N,N'',N''-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE (TPEN)

N,N,N'',N''-Tetrakis-(2-pyridylmethyl)-ethylenediame

N,N,N',N'-Tetra(2-pyridyl)-1,2-ethanediamine

N,N'-Ethylenebis[bis(2-pyridyl)amine]

TPEN, >=98%

TPEDA

TPEN ISO 9001：2015 REACH

N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine

N,N,N'',N''-Tetrakis(2-pyridylmethyl)ethylenediamine

16858-02-9

858-02-9

C26H28N

C26H28N6

BioChemical

Building Blocks

Apoptosis and Cell Cycle

C9 to C46

Cell Biology

Cell Signaling and Neuroscience

Pyridines

DNA metabolism

DNA Synthesis Inhibitors

Heterocyclic Building Blocks

Apoptosis

Aromatics

Chelating Agents & Ligands

Heterocycles

Inhibitors

Apoptosis Inducers