2-Picolylamine
Description Reference- Product Name
- 2-Picolylamine
- CAS No.
- 3731-51-9
- Chemical Name
- 2-Picolylamine
- Synonyms
- pyridin-2-ylmethanamine;2-(AMINOMETHYL)PYRIDINE;DI-(2-PICOLYL)AMINE;C-PYRIDIN-2-YL-METHYLAMINE;2-Picolyamine;2-pyridinemethanamine;(2-Pyridylmethyl)amine;2AMPY;2-Picolinamine;2-PICOLYLAMINE
- CBNumber
- CB8853569
- Molecular Formula
- C6H8N2
- Formula Weight
- 108.14
- MOL File
- 3731-51-9.mol
2-Picolylamine Property
- Melting point:
- 20°C
- Boiling point:
- 82-85 °C12 mm Hg(lit.)
- Density
- 1.049 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.578(lit.)
- Flash point:
- 194 °F
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- form
- Liquid
- pka
- pK1: 2.31(+2);pK2: 8.79(+1) (25°C,μ=0.5)
- color
- Clear colorless to yellow or orange
- PH
- 11-12 (100g/l, H2O, 20℃)
- Water Solubility
- SOLUBLE
- Sensitive
- Air Sensitive
- BRN
- 108054
- CAS DataBase Reference
- 3731-51-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Pyridinemethanamine(3731-51-9)
- EPA Substance Registry System
- 2-Pyridinemethanamine (3731-51-9)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 36/37/38-34-37
- Safety Statements
- 26-36/37/39-45-25-36-27
- RIDADR
- UN 2735 8/PG 2
- WGK Germany
- 3
- RTECS
- US1840000
- Hazard Note
- Corrosive
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 65562
- Product name
- 2-Picolylamine
- Purity
- for HPLC derivatization, ≥98.0% (GC)
- Packaging
- 1ml
- Price
- $33.3
- Updated
- 2022/05/15
- Product number
- A1161
- Product name
- 2-Picolylamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $37
- Updated
- 2024/03/01
- Product number
- A1161
- Product name
- 2-Picolylamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 250g
- Price
- $208
- Updated
- 2024/03/01
- Product number
- B23208
- Product name
- 2-(Aminomethyl)pyridine, 98+%
- Packaging
- 5g
- Price
- $26.65
- Updated
- 2024/03/01
- Product number
- B23208
- Product name
- 2-(Aminomethyl)pyridine, 98+%
- Packaging
- 25g
- Price
- $69.65
- Updated
- 2024/03/01
2-Picolylamine Chemical Properties,Usage,Production
Description
It is usually used as the intermediate or raw material in the organic synthesis and pharmaceutical synthesis. For example, this chemical can promote the Al(OTf)3-catalyzed aminolysis of 1,2-epoxides to produce β-Amino alcohols N-2'-pyridylmethyl in excellent yields.1 Moreover, this substance may function as the raw material to produce copper(Ⅱ) complexes with sulfonamides that act as the active chemical nucleases.2 In addition, by using this chemical as substrate, an efficient [2+3] cycloaddition approach has been developed for the synthesis of pyridyl-appended fullerene ligands.3 Besides, 2-picolylamine is chosen as the recognition group to get better selectivity for a rhodamine-based “turn-on” fluorescent probe for Fe3+ in aqueous solution.4
Reference
- Fringuelli, F.; Pizzo, F.; Tortoioli, S.; Vaccaro, L., Solvent-free Al(OTf)(3)-catalyzed aminolysis of 1,2-epoxides by 2-picolylamine: A key step in the synthesis of ionic liquids. J. Org. Chem. 2004, 69, 7745-7747.
- Macias, B.; Villa, M. V.; Salgado, M.; Borras, J.; Gonzalez-Alvarez, M.; Sanz, F., Copper(II) complexes with sulfonamides derived from 2-picolylamine and their use as chemical nucleases. Inorg. Chim. Acta 2006, 359, 1465-1472.
- Troshin, P. A.; Peregudov, A. S.; Muhlbacher, D.; Lyubovskaya, R. N., An efficient 2+3 cycloaddition approach to the synthesis of pyridyl-appended fullerene ligands. Eur. J. Org. Chem. 2005, 3064-3074.
- Ji, S. Z.; Meng, X. M.; Ye, W. P.; Feng, Y.; Sheng, H. T.; Cai, Y. L.; Liu, J. S.; Zhu, X. F.; Guo, Q. X., A rhodamine-based "turn-on" fluorescent probe for Fe3+ in aqueous solution. Dalton Trans. 2014, 43, 1583-1588.
Chemical Properties
clear colorless to yellow or orange liquid
Uses
2-Picolylamine is a bihaptic amine that can be used:
- As a key precursor to synthesize various ionic liquids through the formation of β-amino alcohols as intermediates.
- As a chelating ligand for the synthesis of complexes such as zinc picolylamine complex and Cu(II) picolylamine complex.
- To functionalize poly(styrene-co-maleic anhydride) (PSMA) resin to facilitate the adsorption of uranium from aqueous solution.
Uses
2-Picolylamine may be used as a derivatization agent to enhance the sensitivity of carboxylic acids and short-chain fatty acids for their determination in biological samples by liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) and ultra-high performance liquid chromatography (UHPLC), respectively.
Definition
ChEBI: 2-Pyridinemethanamine is a member of pyridines.
General Description
2-Picolylamine, a bihaptic nucleophile, is a bidentate ligand that is generally utilized for the preparation of various multidentate ligands and the corresponding complexes.
2-Picolylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Picolylamine manufacturers
- Product
- 2-Aminomethylpyridine 3731-51-9
- Price
- US $57.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 tons
- Release date
- 2023-01-28
- Product
- 2-Picolylamine 3731-51-9
- Price
- US $122.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-11
- Product
- 2-Picolylamine 3731-51-9
- Price
- US $25.00-3.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-09-22