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2-Picolylamine

Description Reference
Product Name
2-Picolylamine
CAS No.
3731-51-9
Chemical Name
2-Picolylamine
Synonyms
pyridin-2-ylmethanamine;2-(AMINOMETHYL)PYRIDINE;DI-(2-PICOLYL)AMINE;C-PYRIDIN-2-YL-METHYLAMINE;2-Picolyamine;2-pyridinemethanamine;(2-Pyridylmethyl)amine;2AMPY;2-Picolinamine;2-PICOLYLAMINE
CBNumber
CB8853569
Molecular Formula
C6H8N2
Formula Weight
108.14
MOL File
3731-51-9.mol
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2-Picolylamine Property

Melting point:
20°C
Boiling point:
82-85 °C12 mm Hg(lit.)
Density 
1.049 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.578(lit.)
Flash point:
194 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
form 
Liquid
pka
pK1: 2.31(+2);pK2: 8.79(+1) (25°C,μ=0.5)
color 
Clear colorless to yellow or orange
PH
11-12 (100g/l, H2O, 20℃)
Water Solubility 
SOLUBLE
Sensitive 
Air Sensitive
BRN 
108054
CAS DataBase Reference
3731-51-9(CAS DataBase Reference)
NIST Chemistry Reference
2-Pyridinemethanamine(3731-51-9)
EPA Substance Registry System
2-Pyridinemethanamine (3731-51-9)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
36/37/38-34-37
Safety Statements 
26-36/37/39-45-25-36-27
RIDADR 
UN 2735 8/PG 2
WGK Germany 
3
RTECS 
US1840000
Hazard Note 
Corrosive
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
65562
Product name
2-Picolylamine
Purity
for HPLC derivatization, ≥98.0% (GC)
Packaging
1ml
Price
$33.3
Updated
2022/05/15
TCI Chemical
Product number
A1161
Product name
2-Picolylamine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$37
Updated
2024/03/01
TCI Chemical
Product number
A1161
Product name
2-Picolylamine
Purity
>98.0%(GC)(T)
Packaging
250g
Price
$208
Updated
2024/03/01
Alfa Aesar
Product number
B23208
Product name
2-(Aminomethyl)pyridine, 98+%
Packaging
5g
Price
$26.65
Updated
2024/03/01
Alfa Aesar
Product number
B23208
Product name
2-(Aminomethyl)pyridine, 98+%
Packaging
25g
Price
$69.65
Updated
2024/03/01
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2-Picolylamine Chemical Properties,Usage,Production

Description

It is usually used as the intermediate or raw material in the organic synthesis and pharmaceutical synthesis. For example, this chemical can promote the Al(OTf)3-catalyzed aminolysis of 1,2-epoxides to produce β-Amino alcohols N-2'-pyridylmethyl in excellent yields.1 Moreover, this substance may function as the raw material to produce copper(Ⅱ) complexes with sulfonamides that act as the active chemical nucleases.2 In addition, by using this chemical as substrate, an efficient [2+3] cycloaddition approach has been developed for the synthesis of pyridyl-appended fullerene ligands.3 Besides, 2-picolylamine is chosen as the recognition group to get better selectivity for a rhodamine-based “turn-on” fluorescent probe for Fe3+ in aqueous solution.4

Reference

  1. Fringuelli, F.; Pizzo, F.; Tortoioli, S.; Vaccaro, L., Solvent-free Al(OTf)(3)-catalyzed aminolysis of 1,2-epoxides by 2-picolylamine: A key step in the synthesis of ionic liquids. J. Org. Chem. 2004, 69, 7745-7747.
  2. Macias, B.; Villa, M. V.; Salgado, M.; Borras, J.; Gonzalez-Alvarez, M.; Sanz, F., Copper(II) complexes with sulfonamides derived from 2-picolylamine and their use as chemical nucleases. Inorg. Chim. Acta 2006, 359, 1465-1472.
  3. Troshin, P. A.; Peregudov, A. S.; Muhlbacher, D.; Lyubovskaya, R. N., An efficient 2+3 cycloaddition approach to the synthesis of pyridyl-appended fullerene ligands. Eur. J. Org. Chem. 2005, 3064-3074.
  4. Ji, S. Z.; Meng, X. M.; Ye, W. P.; Feng, Y.; Sheng, H. T.; Cai, Y. L.; Liu, J. S.; Zhu, X. F.; Guo, Q. X., A rhodamine-based "turn-on" fluorescent probe for Fe3+ in aqueous solution. Dalton Trans. 2014, 43, 1583-1588.

Chemical Properties

clear colorless to yellow or orange liquid

Uses

2-Picolylamine is a bihaptic amine that can be used:

  • As a key precursor to synthesize various ionic liquids through the formation of β-amino alcohols as intermediates.
  • As a chelating ligand for the synthesis of complexes such as zinc picolylamine complex and Cu(II) picolylamine complex.
  • To functionalize poly(styrene-co-maleic anhydride) (PSMA) resin to facilitate the adsorption of uranium from aqueous solution.

Uses

2-Picolylamine may be used as a derivatization agent to enhance the sensitivity of carboxylic acids and short-chain fatty acids for their determination in biological samples by liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) and ultra-high performance liquid chromatography (UHPLC), respectively.

Definition

ChEBI: 2-Pyridinemethanamine is a member of pyridines.

General Description

2-Picolylamine, a bihaptic nucleophile, is a bidentate ligand that is generally utilized for the preparation of various multidentate ligands and the corresponding complexes.

Toxics Screening Level

The initial threshold screening level (ITSL) for 2-(aminomethyl)pyridine is 0.1μg/m3 (annual averaging time).

2-Picolylamine Preparation Products And Raw materials

Raw materials

4-Cyanopyridine Ammonium hydroxide NICKEL ALUMINIDE Nickel Sodium bicarbonate Acetic acid 2-Cyanopyridine

Preparation Products

Flecainide
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View Lastest Price from 2-Picolylamine manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
2-Picolylamine 3731-51-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-11-10
Hebei Yanxi Chemical Co., Ltd.
Product
2-Picolylamine 3731-51-9
Price
US $25.00-3.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-22
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Picolylamine 3731-51-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28

3731-51-9, 2-PicolylamineRelated Search:

2-Chloro-5-chloromethylpyridine 4-Methylpyridine Azamethiphos Pyridine 2,6-Lutidine 2,4,6-Collidine N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE 5H-Pyrrolo[3,4-b]pyridine-5,7(6H)-dione N-Methyl-4-pyridinamine 3-PICOLYLAMINE,3-(AMINOMETHYL)PYRIDINE:3-PICOLYLAMINE 3-HYDROXYPICOLINAMIDE 10-Hydroxycamptothecin PYRIDINE-2-CARBOXAMIDE PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE 2-(Dimethylaminomethyl)-3-hydroxypyridine Pyridine-2-carboximidamide hydrochloride TPEN 6-METHYL-2-PICOLYL-METHYLAMINE

  • (2-Pyridylmethyl)amine
  • 2-(Aminobenzyl)pyridine
  • 2-aminomethyl-pyridin
  • 2-Picolinamine
  • Pyridine-2-methanamine
  • 2-(Aminomethyl)pyridine ,98%
  • 2-Picolylamine,2-(Aminomethyl)pyridine
  • 2-(AMinoMethyl)pyridine, 99% 25ML
  • 2-(AMINOMETHYL)PYRIDINE FOR SYNTHESIS
  • Picolinylamine, (Pyridin-2-yl)methylamine
  • (An Jiaji2-)pyridine
  • 2-PicolylaMine 99%
  • 2 - Methyl pyridine aMMonia
  • 2-pyridinylmethylammonium
  • 2-pyridinemethanamine
  • 2-Pyridinemethylamine
  • 2-Pyridinylmethanamine
  • beta-Picolylamine
  • Pyridine, 2-(aminomethyl)-
  • PICOLYLAMINE (BIS-2-)
  • RARECHEM AH CK 0022
  • TIMTEC-BB SBB004352
  • ALPHA,ALPHA'-IMINODI(2-PICOLINE)
  • AKOS BBS-00003681
  • 2-pyridinemethaneamine
  • 2-PICOLYLAMINE
  • C-PYRIDIN-2-YL-METHYLAMINE
  • DI-(2-PICOLYL)AMINE
  • BIS-2-PICOLYLAMINE
  • 2,2'-DIPICOLYLAMINE
  • 2,2'-BIS(PYRIDYLMETHYL)AMINE
  • 2AMPY
  • 2-(AMINOMETHYL)PYRIDINE
  • 2-(AMINOMETHYL)PYRIDINE,2-PICOLYLAMINE
  • 2-(Aminomethyl)pyridine,99%
  • 2-Picolyamine
  • 1-pyridin-2-ylmethanamine
  • 2-AMINOMETHYL PYRIDINE C-PYRIDIN-2-YL-METHYLAMINE
  • pyridin-2-ylmethanamine
  • 2-Picolylamine &gt
  • 2-(Aminomethyl)pyridine, 99%, for synthesis
  • 2-Pyridylmethylamin
  • 2 - piperidine amine
  • 2-Picolylamine ISO 9001：2015 REACH
  • 3731-51-9
  • 98 1824-81-3
  • AMINE
  • C9 to C46
  • Building Blocks
  • Pyridines
  • Heterocyclic Building Blocks
  • C6
  • Heterocycle-Pyridine series
  • Pyridines derivates
  • Amines
  • bc0001