6-Chloro-9-beta-D-(2,3-isopropylidene)ribofuranosylpurine

Product Name: 6-Chloro-9-beta-D-(2,3-isopropylidene)ribofuranosylpurine
CAS No.: 39824-26-5
Chemical Name: 6-Chloro-9-beta-D-(2,3-isopropylidene)ribofuranosylpurine
Synonyms: 6-Chloro-9-beta-D-(2;6-Chloro-9-[2,3-o-(Isopropylid;3-isopropylidene)ribofuranosylpurine;2',3'-O-Isopropylidene-6-Chloropurine riboside;6-Chloro-9--D-(2,3-isopropylidene)ribofuranosylpurine;6-Chloro-9-b-D-(2,3-isopropylidene)ribofuranosylpurine;6-Chloropurine-9-(2,3-isopropylidene)-b-d-ribfuraniside;6-Chloropurine-9-(2,3-isopropylidene--D-ribofuranoside);6-CHLOROPURINE-9-(2,3-ISOPROPYLIDENE-B-D-RIBOFURANOSIDE);6-Chloropurine-9-(2,3-isopropylidene-β-D-ribofuranoside)
CBNumber: CB6120890
Molecular Formula: C13H15ClN4O4
Formula Weight: 326.74
MOL File: 39824-26-5.mol

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6-Chloro-9-beta-D-(2,3-isopropylidene)ribofuranosylpurine Property

Melting point:: 156-159°C
Boiling point:: 527.8±60.0 °C(Predicted)
Density: 1.79±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), Dichloromethane (Slightly), Diethyl Ether (Slightly)
pka: 14.14±0.10(Predicted)
form: Solid
color: Pale Yellow
optical activity: Consistent with structure
CAS DataBase Reference: 39824-26-5(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C379885
Product name: 6-Chloropurine-9-(2,3-isopropylidene-β-D-ribofuranoside)
Packaging: 250mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: J11096
Product name: 6-Chloro-9-beta-D-(2,3-isopropylidene)ribofuranosylpurine
Packaging: 100mg
Price: $67.2
Updated: 2021/12/16

Ark Pharm

Product number: P000217155
Product name: 6-Chloro-9-[2,3-O-(1-methylethylidene)-beta-D-ribofuranosyl]-9H-Purine
Purity: 97%
Packaging: 25g
Price: $355
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NC04682
Product name: 6-Chloro-9-(2',3'-O-isopropylidene-b-D-ribofuranosyl)purine
Packaging: 5G
Price: $435
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0000582
Product name: 6-CHLORO-9-BETA-D-(2,3-ISOPROPYLIDENE)RIBOFURANOSYLPURINE
Purity: 95.00%
Packaging: 500MG
Price: $500
Updated: 2021/12/16

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6-Chloro-9-beta-D-(2,3-isopropylidene)ribofuranosylpurine Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

6-Chloropurine-9-(2,3-isopropylidene-β-D-ribofuranoside) (cas# 39824-26-5) is a compound useful in organic synthesis.

Synthesis

2004-06-0

67-64-1

39824-26-5

Synthesis of (((3aR,4R,6R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol from (3R,4S,5R)-2-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl) and acetone The general procedure was as follows: to a stirred suspension of anhydrous acetone (300 mL) of (3R,4S,5R)-2-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (3.0 g, 10.5 mmol) was added to toluenesulfonic acid monohydrate (19.8 g, 104 mmol). the solid was completely solubilized after 15 minutes. After 2 hours of reaction, the reaction solution was slowly poured into a stirred aqueous 0.5 N NaHCO3 solution (300 mL). After removing the acetone under vacuum, the mixture was extracted with dichloromethane (DCM, 100 mL x 5). The organic layers were combined, washed sequentially with water (100 mL) and brine (100 mL), dried over anhydrous Na2SO4, filtered and concentrated to give the target product (3.0 g, 87% yield, purity >96%) as a pale white solid. The product was characterized by 1H NMR (500 MHz, CD3OD) and LCMS (m/z: 327.1 [M+1]+).

References

[1] Nucleosides and Nucleotides, 1996, vol. 15, # 1-3, p. 619 - 629
[2] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 7, p. 3848 - 3865
[3] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 8, p. 577 - 582
[4] Patent: WO2012/82436, 2012, A2. Location in patent: Page/Page column 192-193
[5] Patent: WO2012/82436, 2012, A2. Location in patent: Page/Page column 256-257

6-Chloro-9-beta-D-(2,3-isopropylidene)ribofuranosylpurine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-9-beta-D-(2,3-isopropylidene)ribofuranosylpurine Suppliers

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View Lastest Price from 6-Chloro-9-beta-D-(2,3-isopropylidene)ribofuranosylpurine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 6-Chloro-9-beta-D-(2,3-isopropylidene)ribofuranosylpurine 39824-26-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

39824-26-5, 6-Chloro-9-beta-D-(2,3-isopropylidene)ribofuranosylpurineRelated Search:

6-Chloro-9-(2-O-acetyl-5-O-benzoyl-3-azido-3-deoxy-beta-D-ribofuranosyl)-9H-purine 6-Chloro-9-[2-O-acetyl-5-O-(p-toluoyl)-3-azido-3-deoxy-beta-L-ribofuranosyl]-9H-purine 6-Chloro-9-(3,5-di-O-acetyl-2-O-methyl-β-D-ribofuranosyl)-9H-purine Trichloroisocyanuric acid DMT-dT Phosphoramidite DMT-dC(bz) Phosphoramidite DMT-dG(ib) Phosphoramidite DMT-dA(bz) Phosphoramidite DMT-dG(dmf) Phosphoramidite 2',3'-O-Isopropylideneadenosine 6-Chloropurine 6-CHLORO-9-(5-DEOXY-D-RIBOFURANOSYL)PURINE 6-Chloropurine ribonucleoside 6-Chloro-9-beta-D-(2,3-isopropylidene)ribofuranosylpurine 6-CHLOROPURINE-2'-DEOXYRIBOSIDE

6-CHLORO-9-[2.3-0-(ISOPROPYLIDENE)-BETA-D-RIBOFURONOSYL]-9H-PURINE

6-Chloro-9-[2,3-o-(Isopropylid

6-Chloro-9-(2',3'-O-isopropylidene-b-D-ribofuranosyl)purine

6-chloro-9-[230-(isopropylidene)--D-ribofuronosyl]-9H-purine

6-CHLORO-9-[2,3-O-(ISOPROPYLIDENE)-SS-D-RIBOFURONOSYL]-9H-PURINE

6-CHLORO-9-BETA-D-(2,3-ISOPROPYLIDENE)RIBOFURANOSYLPURINE

6-CHLORO-9-[2,3-O-(ISOPROPYLIDENE)-BETA-D-RIBOFURONOSYL]-9H-PURINE

6-CHLOROPURINE-9-(2,3-ISOPROPYLIDENE-B-D-RIBOFURANOSIDE)

6-CHLOROPURINE-9-(2,3-ISOPROPYLIDENE-BETA-D-RIBOFURANOSIDE)

6-Chloropurine-9-(2,3-isopropylidene)-b-d-ribfuraniside

6-CHLORO-9-[2,3-O-(ISOPROPYLIDENE)-β-D-RIBOFURONOSYL]-9H-PURINE

6-Chloro-9-b-D-(2,3-isopropylidene)ribofuranosylpurine

6-CHLORO-9-[2'',3''-0-(ISOPROPYLIDENE)-SS-D-RIBOFURONOSYL]-9H-PURINE

6-Chloro-9--D-(2,3-isopropylidene)ribofuranosylpurine

6-Chloropurine-9-(2,3-isopropylidene--D-ribofuranoside)

6-Chloro-9-[2,3-O-(isopropylidine)-beta-D-ribofuranosyl]-9H-purine

6-Chloro-9-[2,3-O-(1-Methylethylidene)-beta-D-ribofuranosyl]-9H-Purine

6-Chloro-9-(2',3'-O-isopropylidene-beta-D-ribofuranosyl)purine

6-chloro-9-[2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-9H-purine

6-chloro-9-(2,3-O-isopropylidene-β-D-ribofuranosyl)-9H-purine

((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

2',3'-O-Isopropylidene-6-Chloropurine riboside

6-Chloro-9-(2',3'-di-O-isopropylidene-beta-D-ribofuranosyl)purine

9H-Purine, 6-chloro-9-(2,3-O-isopropylidene-β-D-ribofuranosyl)-

[4-(6-chloro-9-purinyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methanol

6-Chloro-9-(2',3'-O-isopropylidene-β-D-ribofuranosyl)purine

9H-Purine, 6-chloro-9-[2,3-O-(1-methylethylidene)-b-D-ribofuranosyl]-

9H-Purine, 6-chloro-9-[2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-

6-Chloropurine-9-(2,3-isopropylidene-β-D-ribofuranoside)

6-Chloro-9-beta-D-(2,3-isopropylidene)ribofuranosylpurine USP/EP/BP

3-isopropylidene)ribofuranosylpurine

6-Chloro-9-beta-D-(2

[(3aR,4R,6R,6aR)-4-(6-chloropurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methanol

6-Chloro-9-[2ˊ.3ˊ-0-(Isopropylidene)-Β-D-Ribofuronosyl]-9H-Purine

(3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methanol

6-Chloro-9-(2’,3’-O-isopropylidene-beta-D-ribofuranosyl)purine

6-Chloropurine-9-(2,3-isopropylidene-β-D-ribofuranoside), CAS 39824-26-5

39824-26-5

C13H15CIN4O4

Bases & Related Reagents

Nucleotides