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CLOBENPROPIT DIHYDROBROMIDE

Product Name
CLOBENPROPIT DIHYDROBROMIDE
CAS No.
145231-45-4
Chemical Name
CLOBENPROPIT DIHYDROBROMIDE
Synonyms
CS-683;VUF 9153;Clobenpropit 2HBr;Clobenpropit dihydro;VUF 9153 DIHYDROBROMIDE;CLOBENPROPIT DIHYDROBROMIDE;Clobenpropit dihydrobromide solid;Clobenpropit dihydrobromide, 95%min;N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA;S-(3-(4(5)-Imidazolyl))propyl-N-(4-chlorobenzyl)isothiourea
CBNumber
CB6122647
Molecular Formula
C14H17ClN4S
Formula Weight
308.83
MOL File
145231-45-4.mol
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CLOBENPROPIT DIHYDROBROMIDE Property

Boiling point:
525.3±60.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: >20 mg/mL
pka
14.55±0.10(Predicted)
form 
solid
color 
white
Water Solubility 
H2O: >20mg/mL
ethanol: 3.30mg/mL
DMSO: >30mg/mL
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris
Product number
0752
Product name
Clobenpropit dihydrobromide
Purity
≥99%(HPLC)
Packaging
10
Price
$193
Updated
2021/12/16
Tocris
Product number
0752
Product name
Clobenpropit dihydrobromide
Purity
≥99%(HPLC)
Packaging
50
Price
$810
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BRS0000115
Product name
CLOBENPROPIT
Purity
99.00%
Packaging
100MG
Price
$2116.25
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BRS0000115
Product name
CLOBENPROPIT
Purity
99.00%
Packaging
10MG
Price
$782.23
Updated
2021/12/16
Crysdot
Product number
CD11253884
Product name
Clobenpropit
Purity
95+%
Packaging
50mg
Price
$790
Updated
2021/12/16
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CLOBENPROPIT DIHYDROBROMIDE Chemical Properties,Usage,Production

Uses

Clobenpropit Dihydrobromide and it’s analogues functions as potent histamine H3 antagonist.

Definition

ChEBI: An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA

Biological Activity

An extremely potent histamine H 3 antagonist/inverse agonist (pA 2 =9.93). Also displays partial agonist activity at H 4 receptors; induces eosinophil shape change with an EC 50 of 3 nM. Also available as part of the Histamine H 3 Receptor Tocriset™ .

Biochem/physiol Actions

Selective H3 histamine receptor antagonist that crosses the blood-brain barrier.

in vivo

Clobenpropit (15 mg/kg; i.p.; once daily for 7 days) counteracts the modulatory effects of MK-801 (HY-15084B) on dopamine and histamine levels and prevents MK-801-induced hyper locomotor behaviors[1].
Clobenpropit (1, 2, 5 μmoL/kg; i.v.) causes a resuscitating effect in rats subjected to the hemorrhagic shock[2].

Animal Model:150-200g, 12-week-old male wistar albino rats[1]
Dosage:15 mg/kg
Administration:I.p.; once daily for 7 days
Result:Exhibited a significant reduction of hyperlocomotor activities induced by a single-dose administration of MK-801 (0.2 mg/kg, i.p.), and reduced the MK-801-induced dopamine release, exhibited further increase in histamine levels in the hypothalamus.
Animal Model:205-470g, adult male Wistar rats[2]
Dosage:1, 2, 5 μmoL/kg (after 6-hydroxydopamine (50 mg/kg (SC) for 3 consecutive days)
Administration:I.v.
Result:Triggered a statistically significant increase of mean arterial pressure (MAP) (dose 2 μmol/kg) and heart rate (HR) (doses of 1, 2, 5 μmol/kg).

IC 50

H3 receptor

CLOBENPROPIT DIHYDROBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CLOBENPROPIT DIHYDROBROMIDE Suppliers

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145231-45-4, CLOBENPROPIT DIHYDROBROMIDERelated Search:

CLOBENPROPIT DIHYDROBROMIDE, VUF 9153 CLOBENPROPIT DIHYDROBROMIDE N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA

  • N-(4-Chlorobenzyl)-S-[3-(4(5)-imidazoyl)propyl]isothiourea dihydrobromide
  • 3-(1H-Imidazol-4-yl)propyl ((4-chlorophenyl)methyl)carbamimidothioate
  • Carbamimidothioic acid, ((4-chlorophenyl)methyl)-, 3-(1H-imidazol-4-yl)propyl ester
  • S-(3-(4(5)-Imidazolyl))propyl-N-(4-chlorobenzyl)isothiourea
  • CarbaMiMidothioic acid, N-[(4-chlorophenyl)Methyl]-, 3-(1H-iMidazol-5-yl)propyl ester
  • [(4-Chlorophenyl)methyl]carbamimidothioic acid 3-(1H-imidazol-4-yl)propyl ester
  • ([4-CHLOROPHENYL]METHYL)-3-(1H-IMIDAZOL-4-YL)PROPYL ESTER CARBAMIMIDOTHIOIC ACID DIHYDROBROMIDE
  • CLOBENPROPIT DIHYDROBROMIDE
  • VUF 9153
  • VUF 9153 DIHYDROBROMIDE
  • N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA
  • N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA DIHYDROBROMIDE
  • VUF 9153, [(4-Chlorophenyl)methyl]-3-(1H-imidazol-4-yl)propyl ester carbamimidothioic acid dihydrobromide
  • CS-683
  • Clobenpropit dihydrobromide solid
  • Clobenpropit dihydro
  • Clobenpropit 2HBr
  • 3-(1H-imidazol-5-yl)propyl N'-(4-chlorobenzyl)carbamimidothioate
  • Clobenpropit dihydrobromide, 95%min
  • 145231-45-4
  • C14H17ClN4S2HBr
  • Histamine receptor