ChemicalBook > CAS DataBase List > 6-FLUOROGRAMINE

6-FLUOROGRAMINE

Product Name: 6-FLUOROGRAMINE
CAS No.: 343-93-1
Chemical Name: 6-FLUOROGRAMINE
Synonyms: 6-FLUOROFLAVONE;6-FLUOROGRAMINE;6-Fluorogramine 97%;3-(DIMETHYLAMINOMETHYL)-6-FLUOROINDOLE;6-FLUORO-3-[DIMETHYLAMINOMETHYL]-INDOLE;3-(Dimethylaminomethyl)-6-fluoro-1H-indole;[(6-fluoro-1H-indol-3-yl)methyl]dimethylamine;1H-Indole-3-methanamine, 6-fluoro-N,N-dimethyl-;(6-Fluoroindole-3-ylmethyl)dimethylamine (6-Fluorogramine)
CBNumber: CB6123189
Molecular Formula: C11H13FN2
Formula Weight: 192.23
MOL File: 343-93-1.mol

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6-FLUOROGRAMINE Property

storage temp.: 2-8°C
Appearance: White to off-white Solid
CAS DataBase Reference: 343-93-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: F592345
Product name: 1-(6-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: PC9114
Product name: 6-Fluorogramine
Purity: 97%
Packaging: 5g
Price: $71
Updated: 2021/12/16

AK Scientific

Product number: W5599
Product name: 1-(6-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine
Packaging: 1g
Price: $93
Updated: 2021/12/16

Matrix Scientific

Product number: 119716
Product name: 1-(6-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine
Purity: 95+%
Packaging: 1g
Price: $126
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0025263
Product name: 6-FLUOROGRAMINE
Purity: 95.00%
Packaging: 250MG
Price: $144.9
Updated: 2021/12/16

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6-FLUOROGRAMINE Chemical Properties,Usage,Production

Synthesis

399-51-9

50-00-0

124-40-3

343-93-1

An aqueous solution of about 40% dimethylamine (35.68 kg, 1.0 eq.) was added to a 250 L reaction vessel under nitrogen protection and the mixture was cooled to about 4.5 °C. Glacial acetic acid (43.4 kg, 2.5 eq.) was slowly added dropwise over a period of 140 minutes while the reaction temperature was controlled to not exceed 15°C. After the dropwise addition was completed, stirring was continued for 20 minutes at about 3°C. Subsequently, 37% formaldehyde aqueous solution (25.9 kg, 1.1 eq.) was slowly added over about 20 minutes, keeping the reaction temperature between 0°C and 10°C. Upon addition of 6-fluoroindole (39.2 kg), the reaction was exothermic raising the temperature to about 40°C and subsequently cooled to about 20°C. The reaction solution was slowly transferred to a 650 L reactor filled with 3M NaOH aqueous solution, taking about 40 minutes. The resulting suspension was stirred at 5°C to 20°C for 40 minutes, the product was collected by filtration, washed with deionized water (120 kg) and dried at 50°C to afford 1-(6-fluoro-1H-indol-3-yl)-N,N-dimethylmethylamine (45.4 kg, 85% yield).

References

[1] Patent: US2011/152539, 2011, A1. Location in patent: Page/Page column 4
[2] Patent: US2016/168089, 2016, A1. Location in patent: Page/Page column 0081; 0082
[3] Chemical Communications, 2016, vol. 52, # 34, p. 5868 - 5871
[4] Journal of Organic Chemistry, 2018, vol. 83, # 17, p. 9902 - 9913
[5] Patent: WO2010/36362, 2010, A1. Location in patent: Page/Page column 44

6-FLUOROGRAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-FLUOROGRAMINE Suppliers

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343-93-1, 6-FLUOROGRAMINERelated Search:

5-FLUOROGRAMINE 4-FLUOROGRAMINE Tiflucarbine 6-Fluoroindole (1H-INDOL-3-YL)METHANAMINE 6-FLUOROGRAMINE Gramine 6-FLUORO-1H-INDOL-3-METHYLAMINE 1H-Indole-3-methanamine, N-methyl- 4'-BROMO-6-FLUOROFLAVONE 6-FLUOROFLAVONE 3'-BROMO-6-FLUOROFLAVONE 4'-CHLORO-6-FLUOROFLAVONE 2'-CHLORO-6-FLUOROFLAVONE 7-Fluorogramine 2'-BROMO-6-FLUOROFLAVONE 2',5'-DIMETHOXY-6-FLUOROFLAVONE

3-(DIMETHYLAMINOMETHYL)-6-FLUOROINDOLE

6-FLUOROGRAMINE

6-FLUORO-3-[DIMETHYLAMINOMETHYL]-INDOLE

3-(Dimethylaminomethyl)-6-fluoro-1H-indole

6-FLUOROFLAVONE

[(6-fluoro-1H-indol-3-yl)methyl]dimethylamine

(6-Fluoroindole-3-ylmethyl)dimethylamine (6-Fluorogramine)

6-Fluorogramine 97%

1H-Indole-3-methanamine, 6-fluoro-N,N-dimethyl-

343-93-1

Biochemicals and Reagents

BioChemical

Luminescent Compounds/Detection

Other luminescent compounds

Indoles and derivatives