Gramine
- Product Name
- Gramine
- CAS No.
- 87-52-5
- Chemical Name
- Gramine
- Synonyms
- Gramin;DONAXINE;1-(1H-indol-3-yl)-N,N-dimethylmethanamine;GRAMINE;Donaxin;Doranine;NSC 16892;GRAMINE(RG);Gramine >Gramine,>99%
- CBNumber
- CB7342118
- Molecular Formula
- C11H14N2
- Formula Weight
- 174.24
- MOL File
- 87-52-5.mol
Gramine Property
- Melting point:
- 132-134 °C (lit.)
- Boiling point:
- 295.23°C (rough estimate)
- Density
- 1.0715 (rough estimate)
- refractive index
- 1.5500 (estimate)
- Flash point:
- 167 °C
- storage temp.
- Refrigerator (+4°C)
- solubility
- almost transparency in Methanol
- form
- Powder
- pka
- 17.00±0.30(Predicted)
- color
- Beige
- Water Solubility
- PRACTICALLY INSOLUBLE
- Merck
- 14,4533
- BRN
- 140521
- LogP
- 2.177 (est)
- CAS DataBase Reference
- 87-52-5(CAS DataBase Reference)
- NIST Chemistry Reference
- 1H-Indole-3-methanamine, N,N-dimethyl-(87-52-5)
- EPA Substance Registry System
- 1H-Indole-3-methanamine, N,N-dimethyl- (87-52-5)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 45-36/37/39-26
- WGK Germany
- 3
- RTECS
- NL7525000
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- G10806
- Product name
- Gramine
- Purity
- 99%
- Packaging
- 25g
- Price
- $135
- Updated
- 2024/03/01
- Product number
- D0653
- Product name
- Gramine
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $34
- Updated
- 2024/03/01
- Product number
- D0653
- Product name
- Gramine
- Purity
- >98.0%(T)
- Packaging
- 250g
- Price
- $168
- Updated
- 2024/03/01
- Product number
- 23401
- Product name
- Gramine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 23401
- Product name
- Gramine
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $214
- Updated
- 2024/03/01
Gramine Chemical Properties,Usage,Production
Chemical Properties
?3-(Dimethylaminomethyl)indole [87-52-5], gramine, C11H14N2, Mr 174.25, mp 138 – 139 ℃, forms colorless needles. The compound is soluble in ethanol, diethyl ether, and chloroform and insoluble in water. It can be synthesized from indole by the Mannich reaction with dimethyl-amine and formaldehyde. Gramine is used to synthesize D,L-tryptophan, the plant growth regulators indole-3-acetic acid and indole-3-butanoic acid as well as the intermediate tryptamine.
Uses
Reactant for preparation of:
- Dopamine D2 receptor antagonists
- Anti-malarial drugs
- 5-indolyl-Mannich bases
- Proliferation inhibitors
- Inhibitors of human mast cell chymase
- Preparation of DL-tryptophan
- Potential detoxification inhibitors of the crucifer phytoalexin brassinin
- 3-vinylindoles
- Serotonin 5-HT6 receptor ligand templates
- Selective protein kinase c delta (PKCδ) down regulators
Definition
ChEBI: Gramine is an aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3. It has a role as a plant metabolite, a serotonergic antagonist, an antiviral agent and an antibacterial agent. It is an aminoalkylindole, an indole alkaloid and a tertiary amino compound. It is a conjugate base of a gramine(1+).
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
storage
Room temperature
Purification Methods
Crystallise gramine from diethyl ether, ethanol or acetone. It sublimes at 59o/0.001mm. The hydrochloride crystallises from EtOH/Et2O with m 190.5-191.0o(dec). [Culvenor et al. Aust J Chem 17 1301 1964, Beilstein 22 III/IV 4302, 22/10 V 25.]
Gramine Preparation Products And Raw materials
Raw materials
Preparation Products
Gramine Suppliers
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View Lastest Price from Gramine manufacturers
- Product
- Gramine 87-52-5
- Price
- US $122.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-11
- Product
- Gramine 87-52-5
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-12-04
- Product
- Gramine 87-52-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10