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Gramine

Product Name
Gramine
CAS No.
87-52-5
Chemical Name
Gramine
Synonyms
Gramin;DONAXINE;1-(1H-indol-3-yl)-N,N-dimethylmethanamine;GRAMINE;Donaxin;Doranine;NSC 16892;GRAMINE(RG);Gramine >Gramine,>99%
CBNumber
CB7342118
Molecular Formula
C11H14N2
Formula Weight
174.24
MOL File
87-52-5.mol
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Gramine Property

Melting point:
132-134 °C (lit.)
Boiling point:
295.23°C (rough estimate)
Density 
1.0715 (rough estimate)
refractive index 
1.5500 (estimate)
Flash point:
167 °C
storage temp. 
Refrigerator (+4°C)
solubility 
almost transparency in Methanol
form 
Powder
pka
17.00±0.30(Predicted)
color 
Beige
Water Solubility 
PRACTICALLY INSOLUBLE
Merck 
14,4533
BRN 
140521
LogP
2.177 (est)
CAS DataBase Reference
87-52-5(CAS DataBase Reference)
NIST Chemistry Reference
1H-Indole-3-methanamine, N,N-dimethyl-(87-52-5)
EPA Substance Registry System
1H-Indole-3-methanamine, N,N-dimethyl- (87-52-5)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
45-36/37/39-26
WGK Germany 
3
RTECS 
NL7525000
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G10806
Product name
Gramine
Purity
99%
Packaging
25g
Price
$135
Updated
2024/03/01
TCI Chemical
Product number
D0653
Product name
Gramine
Purity
>98.0%(T)
Packaging
25g
Price
$34
Updated
2024/03/01
TCI Chemical
Product number
D0653
Product name
Gramine
Purity
>98.0%(T)
Packaging
250g
Price
$168
Updated
2024/03/01
Cayman Chemical
Product number
23401
Product name
Gramine
Purity
≥98%
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23401
Product name
Gramine
Purity
≥98%
Packaging
50mg
Price
$214
Updated
2024/03/01
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Gramine Chemical Properties,Usage,Production

Chemical Properties

?3-(Dimethylaminomethyl)indole [87-52-5], gramine, C11H14N2, Mr 174.25, mp 138 – 139 ℃, forms colorless needles. The compound is soluble in ethanol, diethyl ether, and chloroform and insoluble in water. It can be synthesized from indole by the Mannich reaction with dimethyl-amine and formaldehyde. Gramine is used to synthesize D,L-tryptophan, the plant growth regulators indole-3-acetic acid and indole-3-butanoic acid as well as the intermediate tryptamine.

Uses

Reactant for preparation of:

  • Dopamine D2 receptor antagonists
  • Anti-malarial drugs
  • 5-indolyl-Mannich bases
  • Proliferation inhibitors
  • Inhibitors of human mast cell chymase
  • Preparation of DL-tryptophan
  • Potential detoxification inhibitors of the crucifer phytoalexin brassinin
  • 3-vinylindoles
  • Serotonin 5-HT6 receptor ligand templates
  • Selective protein kinase c delta (PKCδ) down regulators

Definition

ChEBI: Gramine is an aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3. It has a role as a plant metabolite, a serotonergic antagonist, an antiviral agent and an antibacterial agent. It is an aminoalkylindole, an indole alkaloid and a tertiary amino compound. It is a conjugate base of a gramine(1+).

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

storage

Room temperature

Purification Methods

Crystallise gramine from diethyl ether, ethanol or acetone. It sublimes at 59o/0.001mm. The hydrochloride crystallises from EtOH/Et2O with m 190.5-191.0o(dec). [Culvenor et al. Aust J Chem 17 1301 1964, Beilstein 22 III/IV 4302, 22/10 V 25.]

Gramine Preparation Products And Raw materials

Raw materials

Preparation Products

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Gramine Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Ark Pharm, Inc.
Tel
847-367-3680
Fax
847-367-3681
Email
sales@arkpharminc.com
Country
United States
ProdList
1670
Advantage
56
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
55
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12438
Advantage
60
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
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View Lastest Price from Gramine manufacturers

Henan Fengda Chemical Co., Ltd
Product
Gramine 87-52-5
Price
US $122.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-11
Shanghai Standard Technology Co., Ltd.
Product
Gramine 87-52-5
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-12-04
Zhuozhou Wenxi import and Export Co., Ltd
Product
Gramine 87-52-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

87-52-5, GramineRelated Search:


  • n,n-dimethyl-1h-indole-3-methanamine
  • indol-3-ylmethyldimethylamine
  • GCLH / for Cefixime
  • 3-(dimethylaninomethy)in dole
  • Indole, 3-[(dimethylamino)methyl]-
  • n,n-dimethyl-1h-indole-3-methanamin
  • N,N-Dimethyl-1H-indole-3-methylamine
  • TIMTEC-BB SBB003799
  • 1H-Indole-3-methanamine, N,N-dimethyl-
  • (1H-INDOL-3-YLMETHYL)-DIMETHYL-AMINE
  • 3-(DIMETHYLAMINOMETHYL)INDOLE
  • GRAMINE
  • DONAXINE
  • BETA-DIMETHYLAMINOMETHYLINDOLE
  • 3-(DIMETHYLAMINOMETHYL)-INDOLE FOR SYNTH
  • Doranine
  • 3-((N,N-DIMETHYLAMINO)METHYL)INDOLE
  • NSC 16892
  • Gramine,>99%
  • 3-(Dimethylaminomethyl)Indole,Gramines
  • 3-(Dimethy Amino Methyl) Indole
  • 3-(diemthylaminomethyl)indole
  • GRAMINE(3-(DIMETHYLAMINOMETHYL)INDOLE)
  • Gramine or 3-(Dimethylaminomethyl)indole
  • Indole-2-carbocylic acid
  • DONAXINE:GRAMINE
  • Tri(ethenyl)methylsilane
  • 3-Dimethylaminomethyl-1H-indole
  • N,N-Dimethyl-1H-indole-3-ylmethaneamine
  • GRAMINE(RG)
  • 3-(Dimethylaminomethyl)indole Donaxine
  • Arundo donax base
  • 3-(DiMethylaMinoMethyl)indole (graMine)
  • 1H-Indol-3-yl-N,N-dimethylmethanamine
  • 3-((dimethylamino)methyl)-indol
  • 3-Dimethylaminomethylindol (gramin)
  • b-(Dimethylaminomethyl)indole
  • Donaxin
  • Gramin
  • (1H-INDOL-3-YLMETHYL)-DIMETHYL-AMINE (GRAMINE)
  • 3-(Dimethylaminomethyl)-indole for synthesis
  • 3-((N,N-DIMETHYLAMINO)METHYL)INDOLE (GRAMINE)
  • 1-(1H-indol-3-yl)-N,N-dimethylmethanamine
  • Gramine &gt
  • Gramine, ≥ 98.0%
  • 87-52-5
  • C11H14N2
  • Indole Alkaloids
  • Simple Indoles
  • Indoles
  • Alkaloids
  • Building Blocks
  • Heterocyclic Building Blocks
  • Indole
  • Indoles
  • Pharmaceutical Intermediates
  • indole derivative
  • Indoles and derivatives