Gramine

Product Name: Gramine
CAS No.: 87-52-5
Chemical Name: Gramine
Synonyms: Gramin;DONAXINE;1-(1H-indol-3-yl)-N,N-dimethylmethanamine;GRAMINE;Donaxin;Doranine;NSC 16892;GRAMINE(RG);Gramine >Gramine,>99%
CBNumber: CB7342118
Molecular Formula: C11H14N2
Formula Weight: 174.24
MOL File: 87-52-5.mol

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Gramine Property

Melting point:: 132-134 °C (lit.)
Boiling point:: 295.23°C (rough estimate)
Density: 1.0715 (rough estimate)
refractive index: 1.5500 (estimate)
Flash point:: 167 °C
storage temp.: Refrigerator (+4°C)
solubility: almost transparency in Methanol
form: Powder
pka: 17.00±0.30(Predicted)
color: Beige
Water Solubility: PRACTICALLY INSOLUBLE
Merck: 14,4533
BRN: 140521
LogP: 2.177 (est)
CAS DataBase Reference: 87-52-5(CAS DataBase Reference)
NIST Chemistry Reference: 1H-Indole-3-methanamine, N,N-dimethyl-(87-52-5)
EPA Substance Registry System: 1H-Indole-3-methanamine, N,N-dimethyl- (87-52-5)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 45-36/37/39-26
WGK Germany: 3
RTECS: NL7525000
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G10806
Product name: Gramine
Purity: 99%
Packaging: 25g
Price: $135
Updated: 2024/03/01

TCI Chemical

Product number: D0653
Product name: Gramine
Purity: >98.0%(T)
Packaging: 25g
Price: $34
Updated: 2024/03/01

TCI Chemical

Product number: D0653
Product name: Gramine
Purity: >98.0%(T)
Packaging: 250g
Price: $168
Updated: 2024/03/01

Cayman Chemical

Product number: 23401
Product name: Gramine
Purity: ≥98%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23401
Product name: Gramine
Purity: ≥98%
Packaging: 50mg
Price: $214
Updated: 2024/03/01

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Gramine Chemical Properties,Usage,Production

Chemical Properties

?3-(Dimethylaminomethyl)indole [87-52-5], gramine, C11H14N2, Mr 174.25, mp 138 – 139 ℃, forms colorless needles. The compound is soluble in ethanol, diethyl ether, and chloroform and insoluble in water. It can be synthesized from indole by the Mannich reaction with dimethyl-amine and formaldehyde. Gramine is used to synthesize D,L-tryptophan, the plant growth regulators indole-3-acetic acid and indole-3-butanoic acid as well as the intermediate tryptamine.

Uses

Reactant for preparation of:

Dopamine D2 receptor antagonists
Anti-malarial drugs
5-indolyl-Mannich bases
Proliferation inhibitors
Inhibitors of human mast cell chymase
Preparation of DL-tryptophan
Potential detoxification inhibitors of the crucifer phytoalexin brassinin
3-vinylindoles
Serotonin 5-HT6 receptor ligand templates
Selective protein kinase c delta (PKCδ) down regulators

Definition

ChEBI: Gramine is an aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3. It has a role as a plant metabolite, a serotonergic antagonist, an antiviral agent and an antibacterial agent. It is an aminoalkylindole, an indole alkaloid and a tertiary amino compound. It is a conjugate base of a gramine(1+).

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

storage

Room temperature

Purification Methods

Crystallise gramine from diethyl ether, ethanol or acetone. It sublimes at 59o/0.001mm. The hydrochloride crystallises from EtOH/Et2O with m 190.5-191.0o(dec). [Culvenor et al. Aust J Chem 17 1301 1964, Beilstein 22 III/IV 4302, 22/10 V 25.]

Gramine Preparation Products And Raw materials

Raw materials

Indole Dimethylamine

Preparation Products

DL-Tryptophan

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Gramine Suppliers

Americas 1 Belgium 2 Canada 1 China 268 Czech Republic 1 Europe 3 France 3 Germany 7 India 9 Japan 4 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 17 United States 58 Global 380

TCI Chemicals (India) Pvt. Ltd.

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Country: India
ProdList: 6768
Advantage: 58

Vyas Bio Life Sciences Pvt. Ltd

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Country: India
ProdList: 1213
Advantage: 58

Vadivarhe Speciality Chemicals Limited

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Country: India
ProdList: 22
Advantage: 58

Oceanic Pharmachem Pvt. Ltd.

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Country: India
ProdList: 2005
Advantage: 58

Reax Chemicals

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ProdList: 4217
Advantage: 58

Define Chemicals

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Country: India
ProdList: 37
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SL Drugs and Pharmaceuticals Pvt. Ltd.

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Email: enquiry@sldrugs.com
Country: India
ProdList: 2683
Advantage: 50

OCEAN TRADING CORPORATION

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Email: otcchem@otcchem.com
Country: India
ProdList: 6202
Advantage: 58

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View Lastest Price from Gramine manufacturers

Henan Fengda Chemical Co., Ltd

Product: Gramine 87-52-5
Price: US $122.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-11

Shanghai Standard Technology Co., Ltd.

Product: Gramine 87-52-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-12-04

Zhuozhou Wenxi import and Export Co., Ltd

Product: Gramine 87-52-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

87-52-5, GramineRelated Search:

Dimethyl sulfoxide Meglumine Metformin Dimethyl ether Dimethyl carbonate Dimethyl fumarate 2-Methylindole N,N-Dimethylformamide 3-Aminopyridine 3-Dimethylaminopropylamine 2,5-Dimethylindole 2,3-Dimethylindole Flunixin meglumine 4-Dimethylaminopyridine Trimethylamine Dimethyl sebacate Dimethyl phthalate Indole

n,n-dimethyl-1h-indole-3-methanamine

indol-3-ylmethyldimethylamine

GCLH / for Cefixime

3-(dimethylaninomethy)in dole

Indole, 3-[(dimethylamino)methyl]-

n,n-dimethyl-1h-indole-3-methanamin

N,N-Dimethyl-1H-indole-3-methylamine

TIMTEC-BB SBB003799

1H-Indole-3-methanamine, N,N-dimethyl-

(1H-INDOL-3-YLMETHYL)-DIMETHYL-AMINE

3-(DIMETHYLAMINOMETHYL)INDOLE

GRAMINE

DONAXINE

BETA-DIMETHYLAMINOMETHYLINDOLE

3-(DIMETHYLAMINOMETHYL)-INDOLE FOR SYNTH

Doranine

3-((N,N-DIMETHYLAMINO)METHYL)INDOLE

NSC 16892

Gramine,>99%

3-(Dimethylaminomethyl)Indole,Gramines

3-(Dimethy Amino Methyl) Indole

3-(diemthylaminomethyl)indole

GRAMINE(3-(DIMETHYLAMINOMETHYL)INDOLE)

Gramine or 3-(Dimethylaminomethyl)indole

Indole-2-carbocylic acid

DONAXINE:GRAMINE

Tri(ethenyl)methylsilane

3-Dimethylaminomethyl-1H-indole

N,N-Dimethyl-1H-indole-3-ylmethaneamine

GRAMINE(RG)

3-(Dimethylaminomethyl)indole Donaxine

Arundo donax base

3-(DiMethylaMinoMethyl)indole (graMine)

1H-Indol-3-yl-N,N-dimethylmethanamine

3-((dimethylamino)methyl)-indol

3-Dimethylaminomethylindol (gramin)

b-(Dimethylaminomethyl)indole

Donaxin

Gramin

(1H-INDOL-3-YLMETHYL)-DIMETHYL-AMINE (GRAMINE)

3-(Dimethylaminomethyl)-indole for synthesis

3-((N,N-DIMETHYLAMINO)METHYL)INDOLE (GRAMINE)

1-(1H-indol-3-yl)-N,N-dimethylmethanamine

Gramine &gt

Gramine, ≥ 98.0%

87-52-5

C11H14N2

Indole Alkaloids

Simple Indoles

Indoles

Alkaloids

Building Blocks

Heterocyclic Building Blocks

Indole

Indoles

Pharmaceutical Intermediates

indole derivative

Indoles and derivatives