6-FLUOROGRAMINE
- Product Name
- 6-FLUOROGRAMINE
- CAS No.
- 343-93-1
- Chemical Name
- 6-FLUOROGRAMINE
- Synonyms
- 6-FLUOROFLAVONE;6-FLUOROGRAMINE;6-Fluorogramine 97%;3-(DIMETHYLAMINOMETHYL)-6-FLUOROINDOLE;6-FLUORO-3-[DIMETHYLAMINOMETHYL]-INDOLE;3-(Dimethylaminomethyl)-6-fluoro-1H-indole;[(6-fluoro-1H-indol-3-yl)methyl]dimethylamine;1H-Indole-3-methanamine, 6-fluoro-N,N-dimethyl-;(6-Fluoroindole-3-ylmethyl)dimethylamine (6-Fluorogramine)
- CBNumber
- CB6123189
- Molecular Formula
- C11H13FN2
- Formula Weight
- 192.23
- MOL File
- 343-93-1.mol
6-FLUOROGRAMINE Property
- storage temp.
- 2-8°C
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 343-93-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- F592345
- Product name
- 1-(6-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- W5599
- Product name
- 1-(6-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine
- Packaging
- 1g
- Price
- $93
- Updated
- 2021/12/16
- Product number
- 119716
- Product name
- 1-(6-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $378
- Updated
- 2021/12/16
- Product number
- 119716
- Product name
- 1-(6-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $126
- Updated
- 2021/12/16
- Product number
- HCH0025263
- Product name
- 6-FLUOROGRAMINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $144.9
- Updated
- 2021/12/16
6-FLUOROGRAMINE Chemical Properties,Usage,Production
Synthesis
399-51-9
50-00-0
124-40-3
343-93-1
An aqueous solution of about 40% dimethylamine (35.68 kg, 1.0 eq.) was added to a 250 L reaction vessel under nitrogen protection and the mixture was cooled to about 4.5 °C. Glacial acetic acid (43.4 kg, 2.5 eq.) was slowly added dropwise over a period of 140 minutes while the reaction temperature was controlled to not exceed 15°C. After the dropwise addition was completed, stirring was continued for 20 minutes at about 3°C. Subsequently, 37% formaldehyde aqueous solution (25.9 kg, 1.1 eq.) was slowly added over about 20 minutes, keeping the reaction temperature between 0°C and 10°C. Upon addition of 6-fluoroindole (39.2 kg), the reaction was exothermic raising the temperature to about 40°C and subsequently cooled to about 20°C. The reaction solution was slowly transferred to a 650 L reactor filled with 3M NaOH aqueous solution, taking about 40 minutes. The resulting suspension was stirred at 5°C to 20°C for 40 minutes, the product was collected by filtration, washed with deionized water (120 kg) and dried at 50°C to afford 1-(6-fluoro-1H-indol-3-yl)-N,N-dimethylmethylamine (45.4 kg, 85% yield).
References
[1] Patent: US2011/152539, 2011, A1. Location in patent: Page/Page column 4
[2] Patent: US2016/168089, 2016, A1. Location in patent: Page/Page column 0081; 0082
[3] Chemical Communications, 2016, vol. 52, # 34, p. 5868 - 5871
[4] Journal of Organic Chemistry, 2018, vol. 83, # 17, p. 9902 - 9913
[5] Patent: WO2010/36362, 2010, A1. Location in patent: Page/Page column 44
6-FLUOROGRAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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