1,3-DI-BOC-2-METHYLISOTHIOUREA

Product Name: 1,3-DI-BOC-2-METHYLISOTHIOUREA
CAS No.: 107819-90-9
Chemical Name: 1,3-DI-BOC-2-METHYLISOTHIOUREA
Synonyms: 1,3-BIS(TERT-BUTOXYCARBONYL)-2-METHYL-2-THIOPSEUDOUREA;3-DI-BOC-2-METHYLISOTHIOUREA;1,3-DI-BOC-2-METHYLISOTHIOURE;1,3-DI-BOC-2-METHYLISOTHIOUREA;N,N'-DI-BOC-S-METHYLISOTHIOUREA;Bis(Boc)-2-methyl-2-thiopseudourea;N,N'-Di-BOC-S-methylisothiourea 97%;Methyl N,N'-Di-Boc-carbamimidothioate;1,3-Bis-Boc-2-methyl-2-thiopseudourea;1,3-Bis(t-butoxycarbonyl)-2-methylisothiourea
CBNumber: CB6123543
Molecular Formula: C12H22N2O4S
Formula Weight: 290.38
MOL File: 107819-90-9.mol

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1,3-DI-BOC-2-METHYLISOTHIOUREA Property

Melting point:: 115-121 °C(lit.)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Acetonitrile (Very Slightly), Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 6.77±0.46(Predicted)
color: White to Off-White
BRN: 5815984
InChI: InChI=1S/C12H22N2O4S/c1-11(2,3)17-9(15)13-8(19-7)14-10(16)18-12(4,5)6/h1-7H3,(H,13,14,15,16)
InChIKey: UQJXXWHAJKRDKY-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)N=C(NC(OC(C)(C)C)=O)SC

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 439908
Product name: 1,3-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea
Purity: 98%
Packaging: 5g
Price: $146
Updated: 2025/07/31

Sigma-Aldrich

Product number: 439908
Product name: 1,3-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea
Purity: 98%
Packaging: 25g
Price: $569
Updated: 2025/07/31

TCI Chemical

Product number: B4535
Product name: N,N'-Bis(tert-butoxycarbonyl)-S-methylisothiourea
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $72
Updated: 2025/07/31

TCI Chemical

Product number: B4535
Product name: N,N'-Bis(tert-butoxycarbonyl)-S-methylisothiourea
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $248
Updated: 2025/07/31

TRC

Product number: B689720
Product name: 1,3-Bis(tert-butoxycarbonyl)-2-methylisothiourea
Packaging: 1g
Price: $45
Updated: 2021/12/16

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1,3-DI-BOC-2-METHYLISOTHIOUREA Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

Reagent for the guanylation of amines.

Synthesis

24424-99-5

867-44-7

107819-90-9

E) Preparation of N,N'-di-Boc-S-methylisothiourea: Di-tert-butyl dicarbonate (100 g, 458 mmol) was dissolved in tert-butanol (300 mL) under stirring conditions. Subsequently, a solution of S-methylisothiourea sulfate (32.7 g, 117 mmol) in water (150 mL) was slowly added, followed by dropwise addition of sodium hydroxide (19.2 g, 480 mmol) in water (150 mL). The reaction mixture was stirred continuously for 48 hours at room temperature. Upon completion of the reaction, the mixture was concentrated to one-third of the original volume under reduced pressure and then diluted with ether (500 mL). The organic phase was separated and washed once with water (250 mL), three times with 1N citric acid solution (250 mL), and again with water (250 mL), in that order. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 42 g (62% yield) of white solid product.

References

[1] Journal of Organic Chemistry, 1987, vol. 52, # 9, p. 1700 - 1703
[2] Patent: US5914319, 1999, A
[3] Patent: US5705487, 1998, A
[4] Patent: US5710130, 1998, A
[5] Patent: US5726159, 1998, A

1,3-DI-BOC-2-METHYLISOTHIOUREA Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-DI-BOC-2-METHYLISOTHIOUREA Suppliers

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View Lastest Price from 1,3-DI-BOC-2-METHYLISOTHIOUREA manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1,3-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea 107819-90-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 1,3-DI-BOC-2-METHYLISOTHIOUREA 107819-90-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2019-08-05

107819-90-9, 1,3-DI-BOC-2-METHYLISOTHIOUREARelated Search:

N-Boc-cadaverine N,N'-Disuccinimidyl carbonate N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate 1,3-Bis(methoxycarbonyl)-2-methyl-2-thiopseudoeura 1,3-DI-BOC-2-METHYLISOTHIOUREA

N,N'-DI-BOC-S-METHYLISOTHIOUREA

N,N'-BIS(TERT-BUTOXYCARBONYL)-S-METHYLISOTHIOUREA

1,3-DI-BOC-2-METHYLISOTHIOUREA

1,3-BIS(TERT-BUTOXYCARBONYL)-2-METHYL-2-THIOPSEUDOUREA

1,3-bis(tert-butoxycarbonyl)-2-methyl-2-thiopseud

1,3-Di-Boc-2-methylisothiourea, N,Nμ-Di-Boc-S-methylisothiourea, N,Nμ-Bis(tert-butoxycarbonyl)-S-methylisothiourea

1,3-Di-Boc-2-methylisothiourea, N,Nμ-Bis(tert-butoxycarbonyl)-S-methylisothiourea

CarbaMic acid,N-[[[(1,1-diMethylethoxy)carbonyl]aMino](Methylthio)Methylene]-,1,1-

1,3-di-(tert-butoxycarbonyl)-2-Methylisothiourea

[[[(1,1-Dimethylethoxy)carbonyl]amino](methylthio)methylene]carbamic acid 1,1-dimethylethyl ester

1,3-Bis(tert-butoxycarbonyl)-2-methylisothiourea

1,3-Bis(tert-butoxycarbonyl)-2-methylthiopseudourea

1,3-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea,95%

1,3-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea,1,3-Di-Boc-2-methylisothiourea, N,N′-Bis(tert-butoxycarbonyl)-S-methylisothiourea, N,N′-Di-Boc-S-methylisothiourea

N,N'-Di-BOC-S-methylisothiourea 97%

N,N'-Bis(tert-butoxycarbonyl)carbamimidothioic Acid Methyl Ester

1,3-Di-tert-butyloxycarbonyl-S-methylisothiourea

Bis(Boc)-2-methyl-2-thiopseudourea

N,N'-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea

N,N'-Di(tert-butoxycarbonyl)-S-methylisothiourea

N,N'-Bis(tert-butoxycarbonyl)-S-methylisothiourea≥ 98% (TLC)

1,3-DI-BOC-2-METHYLISOTHIOURE

1,3-Bis-(tert-butoxycarbonyl)-2-methyl-2-thiopseudiurea

CarbaMic acid,N-[[[(1,1-diMethylethoxy)carbonyl]aMino](Methylthio)Methylene]-,1,1-diMethylethyl ester

1,3-Bis(t-butoxycarbonyl)-2-methylisothiourea

N,N'-Bis(tert-butoxycarbonyl)-S-methylisothiourea &gt

Methyl N,N'-Bis(tert-butoxycarbonyl)carbamimidothioate

Methyl N,N'-Di-Boc-carbamimidothioate

N,N'-Di-Boc-carbamimidothioic Acid Methyl Ester

3-DI-BOC-2-METHYLISOTHIOUREA

tert-butyl N-[(Z)-{[(tert-butoxy)carbonyl]amino}(methylsulfanyl)methylidene]carbamate

1,3-Bis-Boc-2-methyl-2-thiopseudourea

1,1-Dimethylethyl N-[[[(1,1-dimethylethoxy)carbonyl]amino](methylthio)methylene]carbamate

tert-Butyl N--(N-BOC-amino)-(methylthio)methylenecarbamate

1,1-Dimethylethyl N-[[[(1,1-dimethylethoxy)carbonyl]amino](methylthio)methylene]carbamate (ACI)

1,3-Bis(<i>tert</i>-butoxycarbonyl)-2-methyl-2-thiopseudourea

107819-90-9

CH33CO2CNCSCH3NHCO2CCH33

C12H22N2O4S

Guanidine Protection/Guanidinylation

Specialty Synthesis

Peptide Synthesis