ChemicalBook > CAS DataBase List > ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE

ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE

Product Name: ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE
CAS No.: 88150-75-8
Chemical Name: ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE
Synonyms: Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate;Amlodipine Impurity S;Amlodipine EP Impurity S;Amlodipine IH Impurity C;Benzeneethanol,β-amino-5-methoxy-;Ethyl-4(2-Phthalimido Ethoxy)Acetoacetate;4-(2-PhthaliMidoethoxy)acetoacetic Acid Ethyl Ester;Ethyl-4(2-phthalimido ethoxy)acetoacetate (AMB-Ester);Ethyl 4-[2-(1,3-dioxoisoindol-2-yl)ethoxy]-3-oxobutanoate;Ethyl 4-[2-(1,3-Dioxo-2-isoindolinyl)ethoxy]-3-oxobutanoate
CBNumber: CB61236455
Molecular Formula: C16H17NO6
Formula Weight: 319.31
MOL File: 88150-75-8.mol

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ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE Property

Boiling point:: 479.7±30.0 °C(Predicted)
Density: 1.297±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Sparingly), Methanol (Sparingly)
pka: 9.83±0.46(Predicted)
form: Oil
color: Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: P384570
Product name: 4-(2-Phthalimidoethoxy)acetoaceticAcidEthylEster
Packaging: 250mg
Price: $500
Updated: 2021/12/16

TRC

Product number: P384570
Product name: 4-(2-Phthalimidoethoxy)acetoaceticAcidEthylEster
Packaging: 1g
Price: $1000
Updated: 2021/12/16

ChemScene

Product number: CS-0061613
Product name: Ethyl4-[2-(1,3-dioxoisoindol-2-yl)ethoxy]-3-oxobutanoate
Packaging: 100mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-0061613
Product name: Ethyl4-[2-(1,3-dioxoisoindol-2-yl)ethoxy]-3-oxobutanoate
Packaging: 250mg
Price: $136
Updated: 2021/12/16

AK Scientific

Product number: 4048AC
Product name: Ethyl4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate
Packaging: 100mg
Price: $203
Updated: 2021/12/16

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ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE Chemical Properties,Usage,Production

Uses

4-(2-Phthalimidoethoxy)acetoacetic Acid Ethyl Ester is an intermediate in the synthesis of Amlodipine Besilate (A633500) related compounds.

Synthesis

3891-07-4

638-07-3

88150-75-8

a. Add 2400 mL of tetrahydrofuran to reaction flask A. Cool the mixture to -10°C or lower. Add 750 g of N-hydroxyethylphthalimide and 345 g of NaH sequentially (keep stirring at low speed during addition). Dropwise addition of ethyl 4-chloroacetoacetate was initiated within 30 minutes after addition of N-hydroxyethylphthalimide and NaH. The temperature of the reaction flask was maintained below -10 °C and 732 g of ethyl 4-chloroacetoacetate was slowly added dropwise, controlling the temperature below 0 °C. The dropwise process lasted for 1.5 to 2 hours. The temperature was then raised to 28 to 32 °C and the reaction was carried out for 5 to 6 hours. Upon completion of the reaction, 1500 mL of toluene was added and the temperature was lowered to below 5°C to obtain a toluene dilution of the reaction solution. b. In reaction flask B, 1700 mL of toluene, 2800 mL of water, and 1178 g of acetic acid were added and the temperature was maintained below 5°C. The toluene dilution of the reaction solution obtained in step a was slowly added to the reaction flask B at a temperature below 10°C. The addition process lasted from 1 to 1.5 hours. After stirring for 10 minutes, the mixture was allowed to stand for 15 minutes to separate and remove the aqueous layer. The toluene layer was washed five times with brine (2500 mL each time) with a mass fraction of 4%. Anhydrous magnesium sulfate was added to the washed toluene solution for drying, followed by concentration of the toluene solution under reduced pressure to remove toluene (not less than 2700 mL of toluene was removed, and the toluene content did not exceed a predetermined value) to ultimately obtain ethyl-4-(2-phthalimidoethoxy)acetoacetate in 93% yield.

References

[1] Patent: CN106749187, 2017, A. Location in patent: Paragraph 0031; 0032; 0033; 0034
[2] Patent: WO2004/58711, 2004, A1. Location in patent: Page 18, 19
[3] Patent: WO2005/16885, 2005, A2. Location in patent: Page/Page column 47-49
[4] Patent: WO2005/25507, 2005, A2. Location in patent: Page/Page column 166-167
[5] Patent: WO2005/25507, 2005, A2. Location in patent: Page/Page column 166-167

ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE manufacturers

Career Henan Chemical Co

Product: ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE 88150-75-8
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-17

88150-75-8, ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATERelated Search:

Ethyl 4-bromomethyl-2-(2-pyridyl)thiazole-5-carboxylate, 97% ETHYL 3-CHLOROTETRAFLUOROPROPIONATE 4-(2-HYDROXYPROPYL)PIPERAZINE-1-CARBOXYLIC ACID ETHYL ESTER 3-Ethoxy-4-iodobenzoic acid ethyl ester 5-ALA Ethyl Ester Hydrochloride Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate Loratadine N-Oxide Maleimide Ethyl-2-(diphenylaMino)pyriMidine-5-carboxylate ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE Isopropenylboronic acid pinacol ester

ETHYL-4-(2-(PHTHALIMIDO)ETHOXY)ACETOACET ATE (MEIS S.NO.1122 & COUNTRY GROUP B)

ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE

Ethyl-4(2-Phthalimido Ethoxy)Acetoacetate

Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate

4-(2-PhthaliMidoethoxy)acetoacetic Acid Ethyl Ester

Butanoic acid,4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxo-, ethyl ester

Amlodipine IH Impurity C

Amlodipine Impurity S

Ethyl 4-[2-(1,3-Dioxo-2-isoindolinyl)ethoxy]-3-oxobutanoate

Ethyl 4-[2-(1,3-dioxoisoindol-2-yl)ethoxy]-3-oxobutanoate

ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-...

Ethyl-4(2-phthalido) ethoxy aceto acetateQ: What is Ethyl-4(2-phthalido) ethoxy aceto acetate Q: What is the CAS Number of Ethyl-4(2-phthalido) ethoxy aceto acetate Q: What is the storage condition of Ethyl-4(2-phthalido) ethoxy aceto acetate Q: What are the applications of Ethyl-4(2-phthalido) ethoxy aceto acetate

Ethyl-4(2-phthalimido ethoxy)acetoacetate (AMB-Ester)

Benzeneethanol,β-amino-5-methoxy-

Ethyl 4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoate

Amlodipine EP Impurity S

Ethyl-4(2-Phthalimido Ethoxy)Acetoacetate (Amlodipine intermediate)

88150-75-8