ChemicalBook > CAS DataBase List > NISTC4590527

NISTC4590527

Product Name: NISTC4590527
CAS No.: 4590-52-7
Chemical Name: NISTC4590527
Synonyms: NISTC4590527;7-Fluoro-3,4-dihydroquinolin-2(1H);7-fluoro-3,4-dihydro-2(1H)-Quinolinone;7-Fluoro-3,4-dihydroquinolin-2(1H)-one;2(1H)-Quinolinone, 7-fluoro-3,4-dihydro-
CBNumber: CB61249439
Molecular Formula: C9H8FNO
Formula Weight: 165.16
MOL File: 4590-52-7.mol

Less

NISTC4590527 Property

Boiling point:: 305.8±42.0 °C(Predicted)
Density: 1.241±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 14.01±0.20(Predicted)
Appearance: White to off-white Powder
InChI: InChI=1S/C9H8FNO/c10-7-3-1-6-2-4-9(12)11-8(6)5-7/h1,3,5H,2,4H2,(H,11,12)
InChIKey: KUWDWKUKAVRBKW-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC(F)=C2)CCC1=O

Less

Safety

HS Code: 2933491090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

TRC

Product number: F600385
Product name: 7-Fluoro-3,4-dihydroquinolin-2(1H)-one
Packaging: 25mg
Price: $45
Updated: 2021/12/16

Ark Pharm

Product number: P000503847
Product name: 7-Fluoro-3,4-dihydroquinolin-2(1H)-one
Purity: 95+%
Packaging: 100mg
Price: $99
Updated: 2021/12/16

Ark Pharm

Product number: P000503847
Product name: 7-Fluoro-3,4-dihydroquinolin-2(1H)-one
Purity: 95+%
Packaging: 250mg
Price: $158
Updated: 2021/12/16

Apolloscientific

Product number: PC906505
Product name: 7-Fluoro-3,4-dihydroquinolin-2(1H)-one
Purity: >98%
Packaging: 250mg
Price: $199
Updated: 2021/12/16

Apolloscientific

Product number: PC906505
Product name: 7-Fluoro-3,4-dihydroquinolin-2(1H)-one
Purity: >98%
Packaging: 100mg
Price: $140
Updated: 2021/12/16

Less

NISTC4590527 Chemical Properties,Usage,Production

Uses

7-Fluoro-3,4-dihydroquinolin-2(1H)-one is a useful reagent in the multicomponent one-pot synthesis of 3,4-dihydroquinolinones.

Synthesis

100638-26-4

4590-52-7

General procedure for the synthesis of 7-fluoro-3,4-dihydroquinolin-2(1H)-one from 3-chloro-N-(3-fluorophenyl)propanamide: 3-chloro-N-(3-fluorophenyl)propanamide (10 g, 49.6 mmol) and AlCl3 (23.1 g, 173.6 mmol) were added to a flame-dried 50 mL flask equipped with a magnetic stir bar. The flask was placed in a preheated oil bath, heated to 120-125 °C and kept for 2 h until LC-MS analysis showed that the reaction was complete. After completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched by the slow addition of ice water. The reaction mixture was extracted with EtOAc and the organic phases were combined and washed sequentially with water and saturated brine. The organic layer was dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford the white solid product 7-fluoro-3,4-dihydroquinolin-2(1H)-one (7.63 g, 93.2% yield).

References

[1] Patent: WO2016/66597, 2016, A1. Location in patent: Page/Page column 39
[2] Patent: WO2016/86200, 2016, A1. Location in patent: Page/Page column 273; 274
[3] Patent: WO2012/94462, 2012, A2. Location in patent: Page/Page column 86
[4] Patent: CN106349241, 2017, A. Location in patent: Paragraph 0488; 0492; 0493; 0494; 0495
[5] Patent: WO2008/42735, 2008, A1. Location in patent: Page/Page column 59

NISTC4590527 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

NISTC4590527 Suppliers

China 47 India 1 United States 4 Global 52

Shanghai Chem-Milestone Co., Ltd

Tel: 021-50273253 13641951838
Fax: +86-21-61294436
Email: chemmilestone@163.com
Country: China
ProdList: 151
Advantage: 62

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 15136
Advantage: 55

LABTER PHARMATECH(BEIJING) CO.,LTD

Tel: 010-56330744 18310155299
Fax: 010-56330744
Email: sales@labter.com.cn
Country: China
ProdList: 20000
Advantage: 55

Tcichem, Inc.

Tel: 13918644899
Fax: -
Email: tianchong009@hotmail.com
Country: China
ProdList: 1818
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Dalian lichuang Chemical Co., Ltd

Tel: 0411-0411-00000000 13644282108
Fax: -
Email: 3500508746@qq.com
Country: China
ProdList: 2896
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Sichuan BaiPeng Biotechnology Co., Ltd.

Tel: 028-65791793 18140026355
Fax: QQ568470422
Email: 568470422@qq.com
Country: China
ProdList: 9997
Advantage: 58

Wuxi AppTec

Tel: 022-59987777 13552403979
Email: jia_guoqiang@wuxiapptec.com
Country: China
ProdList: 22345
Advantage: 58

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Jinan chemkey pharmaceutical Co., Ltd.

Tel: 15610156652
Email: baimingshi@163.com
Country: China
ProdList: 981
Advantage: 58

Zhengzhou Ruke Biological Co., Ltd.

Tel: 15981811963
Fax: QQ：1410472904
Email: 1410472904@qq.com
Country: China
ProdList: 5825
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Shanghai Benso Pharmaceutical Technology Co., Ltd.

Tel: 15088289376
Email: 248775804@qq.com
Country: China
ProdList: 4995
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 9989
Advantage: 58

Jining Hengqu Biotechnology Co., Ltd.

Tel: 18118824509
Fax: QQ 574487903
Email: 574487903@qq.com
Country: China
ProdList: 394
Advantage: 58

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: sales@accelachem.com
Country: China
ProdList: 10467
Advantage: 58

Xinyi Guangbang Medical Technology Co., Ltd.

Tel: 13361936468
Email: 410756539@qq.com
Country: China
ProdList: 306
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Chongqing Kemai Material Technology Co., Ltd

Tel: 17830741407
Fax: QQ：2479150351
Email: sales@chem47.com
Country: China
ProdList: 1768
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Jiaxing Zhejia Biotechnology Co., LTD

Tel: 0573-85609002 18367600069;
Email: zhejia01@163.com
Country: China
ProdList: 8886
Advantage: 58

Heze Aiding Pharmaceutical Co., Ltd

Tel: 17661365138
Email: 2845578351@qq.com
Country: China
ProdList: 7115
Advantage: 58

Hebei Boxin Biotechnology Co. , Ltd.

Tel: 19131160546
Email: 2681315246@qq.com
Country: China
ProdList: 13199
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Zibo Biopolar Rongchuang Pharmaceutical Co. Ltd.

Tel: 0533-6092686 13371592196
Email: ddliu@bio-polar.cn
Country: China
ProdList: 2229
Advantage: 58

Foshan Heshuo Pharm technology Co., ltd

Tel: 15363639686
Email: heshuoyiyao@hotmail.com
Country: China
ProdList: 2376
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

Shanghai Fengji Pharmaceutical Technology Co., Ltd

Tel: 15555063509
Email: 153666767@qq.com
Country: China
ProdList: 2751
Advantage: 58

Huanuo Pharmaceutical Technology (Guangxi) Co., Ltd

Tel: 13005928603
Email: 211017228@qq.com
Country: China
ProdList: 8277
Advantage: 58

Jining Yize Pharmaceutical Technology Co., Ltd

Tel: 15192473210
Email: 302633902@qq.com
Country: China
ProdList: 4480
Advantage: 58

Shaanxi Xihua Chemical Industry Co., Ltd

Tel: 029-81136151 17392212881
Email: 1095@dideu.com
Country: China
ProdList: 10001
Advantage: 58

Hunan Hui Bai Yi New Materials Co., Ltd

Tel: 0745-2866551 19976851779
Email: 3002713163@qq.com
Country: China
ProdList: 7333
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

SUZHOU SENFEIDA CHEMICAL CO.,LTD

Tel: +86-0512-83500002 +8618662433356
Email: 3899766280@qq.com
Country: China
ProdList: 26362
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Debye Scientific Corporation

Tel: --
Fax: --
Country: China
ProdList: 6891
Advantage: 50

Less

View Lastest Price from NISTC4590527 manufacturers

Career Henan Chemical Co

Product: NISTC4590527 4590-52-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-09

4590-52-7, NISTC4590527Related Search:

7-FLUORO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 7-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine 7-FLUORO-2-METHYLISATOIC ANHYDRIDE 7-FLUORO-2-METHYL-3H-QUINAZOLIN-4-ONE 7-Fluorooxindole 7-FLUORO-1H-INDOL-3-METHYLAMINE Ethyl 2-(7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate 7-Fluoro-3-iodo-1H-indazole 7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE

7-Fluoro-3,4-dihydroquinolin-2(1H)

2(1H)-Quinolinone, 7-fluoro-3,4-dihydro-

NISTC4590527

7-Fluoro-3,4-dihydroquinolin-2(1H)-one

7-fluoro-3,4-dihydro-2(1H)-Quinolinone

4590-52-7

4548-50-6