NISTC4590527

Product Name: NISTC4590527
CAS No.: 4590-52-7
Chemical Name: NISTC4590527
Synonyms: NISTC4590527;7-Fluoro-3,4-dihydroquinolin-2(1H);7-fluoro-3,4-dihydro-2(1H)-Quinolinone;7-Fluoro-3,4-dihydroquinolin-2(1H)-one;2(1H)-Quinolinone, 7-fluoro-3,4-dihydro-
CBNumber: CB61249439
Molecular Formula: C9H8FNO
Formula Weight: 165.16
MOL File: 4590-52-7.mol

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NISTC4590527 Property

Boiling point:: 305.8±42.0 °C(Predicted)
Density: 1.241±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 14.01±0.20(Predicted)
Appearance: White to off-white Powder
InChI: InChI=1S/C9H8FNO/c10-7-3-1-6-2-4-9(12)11-8(6)5-7/h1,3,5H,2,4H2,(H,11,12)
InChIKey: KUWDWKUKAVRBKW-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC(F)=C2)CCC1=O

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Safety

HS Code: 2933491090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: F600385
Product name: 7-Fluoro-3,4-dihydroquinolin-2(1H)-one
Packaging: 25mg
Price: $45
Updated: 2021/12/16

Ark Pharm

Product number: P000503847
Product name: 7-Fluoro-3,4-dihydroquinolin-2(1H)-one
Purity: 95+%
Packaging: 100mg
Price: $99
Updated: 2021/12/16

Apolloscientific

Product number: PC906505
Product name: 7-Fluoro-3,4-dihydroquinolin-2(1H)-one
Purity: >98%
Packaging: 100mg
Price: $140
Updated: 2021/12/16

Ark Pharm

Product number: P000503847
Product name: 7-Fluoro-3,4-dihydroquinolin-2(1H)-one
Purity: 95+%
Packaging: 250mg
Price: $158
Updated: 2021/12/16

Apolloscientific

Product number: PC906505
Product name: 7-Fluoro-3,4-dihydroquinolin-2(1H)-one
Purity: >98%
Packaging: 250mg
Price: $199
Updated: 2021/12/16

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NISTC4590527 Chemical Properties,Usage,Production

Uses

7-Fluoro-3,4-dihydroquinolin-2(1H)-one is a useful reagent in the multicomponent one-pot synthesis of 3,4-dihydroquinolinones.

Synthesis

100638-26-4

4590-52-7

General procedure for the synthesis of 7-fluoro-3,4-dihydroquinolin-2(1H)-one from 3-chloro-N-(3-fluorophenyl)propanamide: 3-chloro-N-(3-fluorophenyl)propanamide (10 g, 49.6 mmol) and AlCl3 (23.1 g, 173.6 mmol) were added to a flame-dried 50 mL flask equipped with a magnetic stir bar. The flask was placed in a preheated oil bath, heated to 120-125 °C and kept for 2 h until LC-MS analysis showed that the reaction was complete. After completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched by the slow addition of ice water. The reaction mixture was extracted with EtOAc and the organic phases were combined and washed sequentially with water and saturated brine. The organic layer was dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford the white solid product 7-fluoro-3,4-dihydroquinolin-2(1H)-one (7.63 g, 93.2% yield).

References

[1] Patent: WO2016/66597, 2016, A1. Location in patent: Page/Page column 39
[2] Patent: WO2016/86200, 2016, A1. Location in patent: Page/Page column 273; 274
[3] Patent: WO2012/94462, 2012, A2. Location in patent: Page/Page column 86
[4] Patent: CN106349241, 2017, A. Location in patent: Paragraph 0488; 0492; 0493; 0494; 0495
[5] Patent: WO2008/42735, 2008, A1. Location in patent: Page/Page column 59

NISTC4590527 Preparation Products And Raw materials

Raw materials

Preparation Products

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NISTC4590527 Suppliers

China 47 India 1 United States 4 Global 52

Shanghai Chem-Milestone Co., Ltd

Tel: 021-50273253 13641951838
Fax: +86-21-61294436
Email: chemmilestone@163.com
Country: China
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Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
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ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
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LABTER PHARMATECH(BEIJING) CO.,LTD

Tel: 010-56330744 18310155299
Fax: 010-56330744
Email: sales@labter.com.cn
Country: China
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Tcichem, Inc.

Tel: 13918644899
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Email: tianchong009@hotmail.com
Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
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ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
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Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
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Dalian lichuang Chemical Co., Ltd

Tel: 0411-0411-00000000 13644282108
Fax: -
Email: 3500508746@qq.com
Country: China
ProdList: 2896
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
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View Lastest Price from NISTC4590527 manufacturers

Career Henan Chemical Co

Product: NISTC4590527 4590-52-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-09

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7-Fluoro-3,4-dihydroquinolin-2(1H)

2(1H)-Quinolinone, 7-fluoro-3,4-dihydro-

NISTC4590527

7-Fluoro-3,4-dihydroquinolin-2(1H)-one

7-fluoro-3,4-dihydro-2(1H)-Quinolinone

4590-52-7

4548-50-6