1-Boc-4-methylpiperazine
- Product Name
- 1-Boc-4-methylpiperazine
- CAS No.
- 53788-49-1
- Chemical Name
- 1-Boc-4-methylpiperazine
- Synonyms
- 1-BOC-4-METHYLPIPERAZINE;N-Boc-N-methylpiperazine;N-Boc-N-Methylpiperazine-d3;4-Methylpiperazine, N1-BOC protected;N-tert-Butoxycarbonyl-N-methylpiperazine;1-Methyl-4-(tert-butoxycarbonyl)piperazine;tert-butyl 4-methylpiperazine-1-carboxylate;4-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-Methylpiperazine-1-carboxylic Acid tert-Butyl Ester-d3;4-Methyl-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester
- CBNumber
- CB6126665
- Molecular Formula
- C10H20N2O2
- Formula Weight
- 200.28
- MOL File
- 53788-49-1.mol
1-Boc-4-methylpiperazine Property
- Boiling point:
- 254.8±33.0 °C(Predicted)
- Density
- 1.023±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform, Dichloromethane, Ethyl Acetate, Methanol
- pka
- 6.90±0.10(Predicted)
- form
- Oil
- color
- Colorless
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B656970
- Product name
- N-Boc-N-methylpiperazine
- Packaging
- 2g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FB66832
- Product name
- 1-BOC-4-methylpiperazine
- Packaging
- 5G
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CHM0014692
- Product name
- N-BOC-N-METHYLPIPERAZINE
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $739.2
- Updated
- 2021/12/16
- Product number
- 7632
- Product name
- N-Boc-N-methylpiperazine
- Packaging
- 50mg
- Price
- $890
- Updated
- 2021/12/16
- Product number
- CHM0014692
- Product name
- N-BOC-N-METHYLPIPERAZINE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $1871.1
- Updated
- 2021/12/16
1-Boc-4-methylpiperazine Chemical Properties,Usage,Production
Chemical Properties
Colorless Oil
Uses
1-Boc-4-methylpiperazine can be used in the preparation of piperazine-1-carboxamide derivatives as fatty acid amide hydrolase (FAAH) inhibitors.
Synthesis
109-01-3
24424-99-5
53788-49-1
Di-tert-butyl dicarbonate (3.48 mL, 15.0 mmol) was slowly added to a solution of N-methylpiperazine (1.00 g, 10.0 mmol) in tetrahydrofuran (10 mL) under ice bath cooling conditions. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solution was concentrated and the product was purified by silica gel column chromatography. The grades containing 1-boc-4-methylpiperazine were collected, concentrated and dried under reduced pressure to afford the target compound 1-boc-4-methylpiperazine (2.15 g, quantitative yield). The structure of the product was confirmed by 1H-NMR (CDCl3), δ: 3.44 (4H, t, J = 5.0 Hz), 2.34 (4H, t, J = 5.0 Hz), 2.29 (3H, s), 1.46 (9H, s).
References
[1] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2527 - 2532
[2] Patent: EP2703406, 2014, A1. Location in patent: Paragraph 0392
[3] Asian Journal of Chemistry, 2017, vol. 29, # 6, p. 1313 - 1316
[4] Tetrahedron Letters, 2009, vol. 50, # 46, p. 6244 - 6246
[5] Journal of Organic Chemistry, 2006, vol. 71, # 21, p. 8283 - 8286
1-Boc-4-methylpiperazine Preparation Products And Raw materials
Raw materials
Preparation Products
1-Boc-4-methylpiperazine Suppliers
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