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ChemicalBook > CAS DataBase List > DMT-dA(bz) Phosphoramidite

DMT-dA(bz) Phosphoramidite

Physical form Color
Product Name
DMT-dA(bz) Phosphoramidite
CAS No.
98796-53-3
Chemical Name
DMT-dA(bz) Phosphoramidite
Synonyms
DMT-dA(bz) PhosphoraMidite;DMT-dA(Bz)-CE;DMT-dA(bz) AMidite;Bz-dA Phosphoramidite;DMT-dA(bz) Pharmadite;DA-CE PHOSPHORAMIDITE;DNA A PHOSPHORAMIDITE;DMT-dA(Bz)-CE Amidites;DMT-dA-CEPhosphoramidite;2'-dA(Bz)Phosphoramidite
CBNumber
CB6127091
Molecular Formula
C47H52N7O7P
Formula Weight
857.93
MOL File
98796-53-3.mol
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DMT-dA(bz) Phosphoramidite Property

Density 
1.23 at 20℃
vapor pressure 
0-0Pa at 20-50℃
storage temp. 
Sealed in dry,2-8°C
solubility 
soluble, clear
form 
powder or granules
pka
7.87±0.43(Predicted)
color 
white to off-white
biological source
non-animal source (no BSE/TSE risk)
Water Solubility 
soluble, clear
InChI
InChI=1S/C47H52N7O7P/c1-32(2)54(33(3)4)62(59-27-13-26-48)61-40-28-42(53-31-51-43-44(49-30-50-45(43)53)52-46(55)34-14-9-7-10-15-34)60-41(40)29-58-47(35-16-11-8-12-17-35,36-18-22-38(56-5)23-19-36)37-20-24-39(57-6)25-21-37/h7-12,14-25,30-33,40-42H,13,27-29H2,1-6H3,(H,49,50,52,55)/t40-,41+,42+,62?/m0/s1
InChIKey
GGDNKEQZFSTIMJ-AKWFTNRHSA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3C(=C(N=CN=3)NC(=O)C3=CC=CC=C3)N=C2)C[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N
LogP
7.14 at 20℃
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Safety

WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A111040
Product name
DMT-dA(bz) Phosphoramidite
Purity
configured for MerMade
Packaging
6x9.46g
Price
$600
Updated
2025/07/31
Sigma-Aldrich
Product number
A111040
Product name
DMT-dA(bz) Phosphoramidite
Purity
configured for MerMade
Packaging
6x19.3g
Price
$1550
Updated
2025/07/31
Sigma-Aldrich
Product number
A111000
Product name
DMT-dA(bz) Phosphoramidite
Purity
≥99% (31P-NMR)
Packaging
6x5g
Price
$512
Updated
2025/07/31
Sigma-Aldrich
Product number
A111000
Product name
DMT-dA(bz) Phosphoramidite
Packaging
214.6g
Price
$3660
Updated
2025/07/31
Sigma-Aldrich
Product number
A111000
Product name
DMT-dA(bz) Phosphoramidite
Packaging
40X10G
Price
$3785
Updated
2025/07/31
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DMT-dA(bz) Phosphoramidite Chemical Properties,Usage,Production

Physical form

Powder or granules

Color

White to off-white

General Description

DMT-dA(bz) Phosphoramidite belongs to the group of DNA Phosphoramidites. Its key features include:
Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib)).
Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution,for standard base-protected oligonucleotides.
The high coupling efficiency of Proligo′s DNA phosphoramidites leads tohigh-yield and high-quality oligonucleotides.

Uses

N6-Benzoyl-2’-deoxy-5’-O-DMT-cytidine 3’-CE Phosphoramidite is used to prepare antisense oligonucleotides containing conformationally constrained methoxyaminomethylene and aminooxymethylene and aminomethylene bridged nucleoside analogs.

Synthesis

131420-63-8

64325-78-6

98796-53-3

Synthesis of (2R,3S,5R)-5-(6-benzoylamino-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide from N-(9-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4- hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide: The general procedure for synthesizing (2R,3S,5R)-5-(6-benzoylamino-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl) Methoxy)methyl)tetrahydrofuran-3-yl(2-cyanoethyl)diisopropylphosphoramidite was carried out in the following general steps: the nucleoside was phosphorylated using the N-methylimidazole salts of [O-β-cyanoethyl-N,N,N',N'-tetraisopropylphosphoramidite] and saccharin as the activators. This was done as follows: nucleoside (1.5 mmol) was added in a flask of appropriate size and the solid was dried by azeotropic distillation twice (using a rotary evaporator) with 20 mL of pyridine. After purging the flask with argon, 15 mL of acetonitrile was added. The mixture was stirred at room temperature until a clarified solution was formed. Subsequently, [O-β-cyanoethyl-N,N,N',N'-tetraisopropylphosphoramidite] (Tetraphos) was added to the solution, followed by the N-methylimidazole salt of saccharin. The reaction mixture was stirred continuously at room temperature and the progress of the reaction was monitored by HPLC. Upon completion of the reaction, the mixture was diluted with 30 mL of ethyl acetate and the organic phase was washed sequentially with 2 x 25 mL of saturated aqueous sodium bicarbonate and 25 mL of saturated aqueous sodium chloride. The organic layer was separated and dried with anhydrous magnesium sulfate. The dried suspension was filtered and the solvent was removed using a rotary evaporator. Finally, the residue was dried under vacuum to obtain the target product as a foamy solid.

References

[1] Patent: WO2004/35599, 2004, A1. Location in patent: Page 9-10
[2] Patent: WO2004/35599, 2004, A1. Location in patent: Page 10-11

DMT-dA(bz) Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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DMT-dA(bz) Phosphoramidite Suppliers

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View Lastest Price from DMT-dA(bz) Phosphoramidite manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
DMT-dA(bz) Phosphoramidite 98796-53-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-23
Hefei Huana Biomedical Technology Co.,Ltd.
Product
DMT-dA(Bz)-CE 98796-53-3
Price
US $0.00/g
Min. Order
10g
Purity
≥99%
Supply Ability
20tons
Release date
2023-03-09
R&D Scientific Inc.
Product
Dmt-da(bz) phosphoramidite 98796-53-3
Price
US $1000.00/g
Min. Order
1g
Purity
95
Supply Ability
500 Kg
Release date
2024-02-11

98796-53-3, DMT-dA(bz) PhosphoramiditeRelated Search:

3-Mercaptopropyltriethoxysilane 3-Chloropropyltrimethoxysilane Benzoyl peroxide Vidarabine Trimethoxypropylsilane Adenosine5'-(tetrahydrogen triphosphate), disodiuM salt, trihydrate (9CI) 3-Aminopropyltriethoxysilane ADENOSINE 5'-TRIPHOSPHATASE 3-Chloropropyltriethoxysilane 2'-Deoxyadenosine monohydrate Cyclic AMP Benzoyl chloride Adenosine 2'-Deoxyadenosine 5'-Deoxyadenosylcobalamin DMT-2'O-TBDMS-rA(bz) Phosphoramidite N6-Benzoyl-2'-deoxyadenosine 5'-O-FDMT-N6-BENZOYL-2'-DEOXYADENOSINE CEP

  • DMT-dA(bz) PhosphoraMidite
  • N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine 5'-CE phosphoramidite
  • N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-CE phosphoramidite
  • 2'DEOXYADENOSINE PHOSPHORAMADITE
  • 2'-DEOXYADENOSINE PHOSPHORAMIDITE
  • dA(N-Bz) Phosphoramidite
  • N-blocked-5'-O-DMT 3'-CED deoxyadenosine phosphoramidite
  • (2R,3S,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite
  • REF DUPL: dA(bz) Phosphoramidite
  • Bz-dA Phosphoramidite
  • DMT-dA(bz) AMidite
  • N<sup>6</sup>-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-CE phosphoraMidite
  • 3'-O-P-5'-O-DMT-N-BZ-2'-DEOXY-ADENOSINE [DA(BZ) PHOSPHORAMIDITE]
  • 5'-Dimethoxytrityl-N-benzoyl-2'-deoxyAdenosine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • DMT-dA-CEPhosphoramidite
  • 5'-O-DMT-N6-Benzoyl-2'-deoxyadenosine 3'-CE phosphoramidite
  • deoxyadenosine-ce phosphoramidite for cyclone
  • -(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • N6-Benzoyl-5'-O-DMT-2'-deoxyadenosine-3'-CE Phosphoramidite
  • DMT-dA(Bz)-CE Phosphoramidite
  • N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-cyanoethyl Phosphoramidite
  • N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
  • 5'-O-DMT-N6-Benzyoyl-2'-Deoxy Adenosine Phosphoramidite
  • N6-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE Phosphoramidite
  • DMT-dA(bz) Pharmadite
  • DA-CE PHOSPHORAMIDITE
  • DNA A PHOSPHORAMIDITE
  • N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-adenosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
  • N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYADENOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE
  • DMT-DA(BZ) AMIDITE 10G SINGLE
  • DMT-DA(BZ) AMIDITE 2G AB 12 PACK
  • DMT-dA(bz) Amidite, 5g, 6pack
  • DMT-dA(bz) Amidite 1g, 89, 12 Pack
  • DMT-dA(bz) Amidite 8.05g, 6 Pack
  • DMT-dA(bz) Amidite 2g, 89, 12 Pack
  • DMT-dA(bz) Amidite 1g, 60ml vial, 12 Pac
  • DMT-dA(bz) Amidite 20g, 6 Pack
  • DMT-DA(BZ) AMIDITE 5G SINGLE
  • DMT-dA(bz) Amidite 2g, 60ml vial, 12 Pac
  • DMT-DA(BZ) AMIDITE 4G 60ML VIAL 12 PAC
  • DMT-DA(BZ) AMIDITE 1G AB 12 PACK
  • N6-benzoyl-DMT-2'-deoxyadenosine-3'-CE Phosphoramidite
  • Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • DMT-Bz-dA phosphoramidite
  • 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite USP/EP/BP
  • 5'-DMT-Bz-dA phosphoramidite
  • N6-Benzoyl-2’-deoxy-5’-O-dimethoxytrityladenosine-3’-O-diisopropylaminocyanoethylphosphoramidite
  • N6-Benzoyl-5'-O-DMT-2’-dA-3'-CE Phosphoramidite
  • (2R,3S,5S)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxy phenyl)(phenyl)methoxy)methyl)-tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite
  • 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 5'-O-DMT-dA(BZ)-CE-Phosphoramidite
  • 5'-O-DMT-N6-Benzoyl-2'-Deoxyadenosine-CE Phosphoramidite
  • DMT-dA(Bz)-CE
  • N-[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide
  • dA(Bz) CE Phosphoramidite
  • 5'-O-DMT-N6-Benzoyl-2'-Deoxy Adenosine-3’-Cyanoethyl Phosphoramidite
  • deoxy N-Bz Adenosine Amidite
  • DMT-dA(Bz)-CE Amidites