DMT-dA(bz) Phosphoramidite

Physical form Color

Product Name: DMT-dA(bz) Phosphoramidite
CAS No.: 98796-53-3
Chemical Name: DMT-dA(bz) Phosphoramidite
Synonyms: DMT-dA(bz) PhosphoraMidite;DMT-dA(Bz)-CE;DMT-dA(bz) AMidite;Bz-dA Phosphoramidite;DMT-dA(bz) Pharmadite;DA-CE PHOSPHORAMIDITE;DNA A PHOSPHORAMIDITE;DMT-dA(Bz)-CE Amidites;DMT-dA-CEPhosphoramidite;2'-dA(Bz)Phosphoramidite
CBNumber: CB6127091
Molecular Formula: C47H52N7O7P
Formula Weight: 857.93
MOL File: 98796-53-3.mol

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DMT-dA(bz) Phosphoramidite Property

Density: 1.23 at 20℃
vapor pressure: 0-0Pa at 20-50℃
storage temp.: Sealed in dry,2-8°C
solubility: soluble, clear
form: powder or granules
pka: 7.87±0.43(Predicted)
color: white to off-white
biological source: non-animal source (no BSE/TSE risk)
Water Solubility: soluble, clear
InChI: InChI=1S/C47H52N7O7P/c1-32(2)54(33(3)4)62(59-27-13-26-48)61-40-28-42(53-31-51-43-44(49-30-50-45(43)53)52-46(55)34-14-9-7-10-15-34)60-41(40)29-58-47(35-16-11-8-12-17-35,36-18-22-38(56-5)23-19-36)37-20-24-39(57-6)25-21-37/h7-12,14-25,30-33,40-42H,13,27-29H2,1-6H3,(H,49,50,52,55)/t40-,41+,42+,62?/m0/s1
InChIKey: GGDNKEQZFSTIMJ-AKWFTNRHSA-N
SMILES: O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3C(=C(N=CN=3)NC(=O)C3=CC=CC=C3)N=C2)C[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N
LogP: 7.14 at 20℃

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Safety

WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A111040
Product name: DMT-dA(bz) Phosphoramidite
Purity: configured for MerMade
Packaging: 6x9.46g
Price: $600
Updated: 2025/07/31

Sigma-Aldrich

Product number: A111040
Product name: DMT-dA(bz) Phosphoramidite
Purity: configured for MerMade
Packaging: 6x19.3g
Price: $1550
Updated: 2025/07/31

Sigma-Aldrich

Product number: A111000
Product name: DMT-dA(bz) Phosphoramidite
Purity: ≥99% (31P-NMR)
Packaging: 6x5g
Price: $512
Updated: 2025/07/31

Sigma-Aldrich

Product number: A111000
Product name: DMT-dA(bz) Phosphoramidite
Packaging: 214.6g
Price: $3660
Updated: 2025/07/31

Sigma-Aldrich

Product number: A111000
Product name: DMT-dA(bz) Phosphoramidite
Packaging: 40X10G
Price: $3785
Updated: 2025/07/31

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DMT-dA(bz) Phosphoramidite Chemical Properties,Usage,Production

Physical form

Powder or granules

Color

White to off-white

General Description

DMT-dA(bz) Phosphoramidite belongs to the group of DNA Phosphoramidites. Its key features include:
Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib)).
Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution,for standard base-protected oligonucleotides.
The high coupling efficiency of Proligo′s DNA phosphoramidites leads tohigh-yield and high-quality oligonucleotides.

Uses

N6-Benzoyl-2’-deoxy-5’-O-DMT-cytidine 3’-CE Phosphoramidite is used to prepare antisense oligonucleotides containing conformationally constrained methoxyaminomethylene and aminooxymethylene and aminomethylene bridged nucleoside analogs.

Synthesis

131420-63-8

64325-78-6

98796-53-3

Synthesis of (2R,3S,5R)-5-(6-benzoylamino-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide from N-(9-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4- hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide: The general procedure for synthesizing (2R,3S,5R)-5-(6-benzoylamino-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl) Methoxy)methyl)tetrahydrofuran-3-yl(2-cyanoethyl)diisopropylphosphoramidite was carried out in the following general steps: the nucleoside was phosphorylated using the N-methylimidazole salts of [O-β-cyanoethyl-N,N,N',N'-tetraisopropylphosphoramidite] and saccharin as the activators. This was done as follows: nucleoside (1.5 mmol) was added in a flask of appropriate size and the solid was dried by azeotropic distillation twice (using a rotary evaporator) with 20 mL of pyridine. After purging the flask with argon, 15 mL of acetonitrile was added. The mixture was stirred at room temperature until a clarified solution was formed. Subsequently, [O-β-cyanoethyl-N,N,N',N'-tetraisopropylphosphoramidite] (Tetraphos) was added to the solution, followed by the N-methylimidazole salt of saccharin. The reaction mixture was stirred continuously at room temperature and the progress of the reaction was monitored by HPLC. Upon completion of the reaction, the mixture was diluted with 30 mL of ethyl acetate and the organic phase was washed sequentially with 2 x 25 mL of saturated aqueous sodium bicarbonate and 25 mL of saturated aqueous sodium chloride. The organic layer was separated and dried with anhydrous magnesium sulfate. The dried suspension was filtered and the solvent was removed using a rotary evaporator. Finally, the residue was dried under vacuum to obtain the target product as a foamy solid.

References

[1] Patent: WO2004/35599, 2004, A1. Location in patent: Page 9-10
[2] Patent: WO2004/35599, 2004, A1. Location in patent: Page 10-11

DMT-dA(bz) Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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DMT-dA(bz) Phosphoramidite Suppliers

Canada 2 China 192 Germany 1 India 8 Switzerland 1 United Kingdom 3 United States 14 Global 221

Hongene Biotech Corporation

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Nanjing Youwei Biotechnology Co., Ltd

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Wuhu Huaren Science and Technology Co., Ltd.

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Nugene Biopharm Science (Hangzhou) Co., Ltd.

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Wuhan Tangzhi Pharmaceutical Co., Ltd.

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J & K SCIENTIFIC LTD.

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Energy Chemical

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Adamas Reagent, Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

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Chengdu Pukang Biotechnology Co., Ltd

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View Lastest Price from DMT-dA(bz) Phosphoramidite manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: DMT-dA(bz) Phosphoramidite 98796-53-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-23

Hefei Huana Biomedical Technology Co.,Ltd.

Product: DMT-dA(Bz)-CE 98796-53-3
Price: US $0.00/g
Min. Order: 10g
Purity: ≥99%
Supply Ability: 20tons
Release date: 2023-03-09

R&D Scientific Inc.

Product: Dmt-da(bz) phosphoramidite 98796-53-3
Price: US $1000.00/g
Min. Order: 1g
Purity: 95
Supply Ability: 500 Kg
Release date: 2024-02-11

98796-53-3, DMT-dA(bz) PhosphoramiditeRelated Search:

3-Mercaptopropyltriethoxysilane 3-Chloropropyltrimethoxysilane Benzoyl peroxide Vidarabine Trimethoxypropylsilane Adenosine5'-(tetrahydrogen triphosphate), disodiuM salt, trihydrate (9CI) 3-Aminopropyltriethoxysilane ADENOSINE 5'-TRIPHOSPHATASE 3-Chloropropyltriethoxysilane 2'-Deoxyadenosine monohydrate Cyclic AMP Benzoyl chloride Adenosine 2'-Deoxyadenosine 5'-Deoxyadenosylcobalamin DMT-2'O-TBDMS-rA(bz) Phosphoramidite N6-Benzoyl-2'-deoxyadenosine 5'-O-FDMT-N6-BENZOYL-2'-DEOXYADENOSINE CEP

DMT-dA(bz) PhosphoraMidite

N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine 5'-CE phosphoramidite

N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-CE phosphoramidite

2'DEOXYADENOSINE PHOSPHORAMADITE

2'-DEOXYADENOSINE PHOSPHORAMIDITE

dA(N-Bz) Phosphoramidite

N-blocked-5'-O-DMT 3'-CED deoxyadenosine phosphoramidite

(2R,3S,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite

REF DUPL: dA(bz) Phosphoramidite

Bz-dA Phosphoramidite

DMT-dA(bz) AMidite

N<sup>6</sup>-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-CE phosphoraMidite

3'-O-P-5'-O-DMT-N-BZ-2'-DEOXY-ADENOSINE [DA(BZ) PHOSPHORAMIDITE]

5'-Dimethoxytrityl-N-benzoyl-2'-deoxyAdenosine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

DMT-dA-CEPhosphoramidite

5'-O-DMT-N6-Benzoyl-2'-deoxyadenosine 3'-CE phosphoramidite

deoxyadenosine-ce phosphoramidite for cyclone

-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

N6-Benzoyl-5'-O-DMT-2'-deoxyadenosine-3'-CE Phosphoramidite

DMT-dA(Bz)-CE Phosphoramidite

N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-cyanoethyl Phosphoramidite

N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]

5'-O-DMT-N6-Benzyoyl-2'-Deoxy Adenosine Phosphoramidite

N6-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE Phosphoramidite

DMT-dA(bz) Pharmadite

DA-CE PHOSPHORAMIDITE

DNA A PHOSPHORAMIDITE

N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-adenosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYADENOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE

DMT-DA(BZ) AMIDITE 10G SINGLE

DMT-DA(BZ) AMIDITE 2G AB 12 PACK

DMT-dA(bz) Amidite, 5g, 6pack

DMT-dA(bz) Amidite 1g, 89, 12 Pack

DMT-dA(bz) Amidite 8.05g, 6 Pack

DMT-dA(bz) Amidite 2g, 89, 12 Pack

DMT-dA(bz) Amidite 1g, 60ml vial, 12 Pac

DMT-dA(bz) Amidite 20g, 6 Pack

DMT-DA(BZ) AMIDITE 5G SINGLE

DMT-dA(bz) Amidite 2g, 60ml vial, 12 Pac

DMT-DA(BZ) AMIDITE 4G 60ML VIAL 12 PAC

DMT-DA(BZ) AMIDITE 1G AB 12 PACK

N6-benzoyl-DMT-2'-deoxyadenosine-3'-CE Phosphoramidite

Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

DMT-Bz-dA phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite USP/EP/BP

5'-DMT-Bz-dA phosphoramidite

N6-Benzoyl-2’-deoxy-5’-O-dimethoxytrityladenosine-3’-O-diisopropylaminocyanoethylphosphoramidite

N6-Benzoyl-5'-O-DMT-2’-dA-3'-CE Phosphoramidite

(2R,3S,5S)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxy phenyl)(phenyl)methoxy)methyl)-tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

5'-O-DMT-dA(BZ)-CE-Phosphoramidite

5'-O-DMT-N6-Benzoyl-2'-Deoxyadenosine-CE Phosphoramidite

DMT-dA(Bz)-CE

N-[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide

dA(Bz) CE Phosphoramidite

5'-O-DMT-N6-Benzoyl-2'-Deoxy Adenosine-3’-Cyanoethyl Phosphoramidite

deoxy N-Bz Adenosine Amidite

DMT-dA(Bz)-CE Amidites