ChemicalBook > CAS DataBase List > Methyl 1H-indazole-6-carboxylate

Methyl 1H-indazole-6-carboxylate

Product Name: Methyl 1H-indazole-6-carboxylate
CAS No.: 170487-40-8
Chemical Name: Methyl 1H-indazole-6-carboxylate
Synonyms: 1H-indazole-6-carboxylate;Methyl indazole-6-carboxy...;Methyl indazole-6-carboxylate;Methyl 1H-indazol-6-carboxylate;METHYL 1H-INDAZOLE-6-CARBOXYLATE;1H-Indazole-6-carboxylic acid methyl;INDAZOLE-6-CARBOXYLIC ACID METHYL ESTER;1H-Indazole-6-carboxylic acid methyl ester;6-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER;1H-Indazole-6-carboxylic acid methyl ester
CBNumber: CB6127192
Molecular Formula: C9H8N2O2
Formula Weight: 176.17
MOL File: 170487-40-8.mol

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Methyl 1H-indazole-6-carboxylate Property

Melting point:: 142-144℃
Boiling point:: 345.2±15.0 °C(Predicted)
Density: 1.324±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: 12.43±0.40(Predicted)
color: White to Light yellow to Light orange
Water Solubility: Soluble in water.
InChI: InChI=1S/C9H8N2O2/c1-13-9(12)6-2-3-7-5-10-11-8(7)4-6/h2-5H,1H3,(H,10,11)
InChIKey: TUSICEWIXLMXEY-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC(C(OC)=O)=C2)C=N1

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Safety

WGK Germany: 3
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00165
Product name: 1H-Indazole-6-carboxylic acid methyl ester
Purity: Aldrich
Packaging: 1g
Price: $201
Updated: 2023/01/07

TCI Chemical

Product number: M2823
Product name: Methyl Indazole-6-carboxylate
Purity: >97.0%(GC)
Packaging: 1g
Price: $29
Updated: 2025/07/31

TCI Chemical

Product number: M2823
Product name: Methyl Indazole-6-carboxylate
Purity: >97.0%(GC)
Packaging: 5g
Price: $84
Updated: 2025/07/31

TRC

Product number: M321405
Product name: Methyl1H-Indazole-6-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 069837
Product name: 1H-Indazole-6-carboxylic acid methyl ester
Purity: 97%
Packaging: 1g
Price: $72
Updated: 2021/12/16

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Methyl 1H-indazole-6-carboxylate Chemical Properties,Usage,Production

Uses

Methyl 1H-indazole-6-carboxylate?is used in organic synthesis.

Synthesis

18595-18-1

170487-40-8

Example 1 Preparation of 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethylcarbamoyl)-1H-indazol-3-yl)cyclohex-3-enecarboxylic acid (1A) Step 1: Preparation of methyl 1H-indazole-6-carboxylate (A-2). Methyl 3-amino-4-methylbenzoate (A-1) (5.0 g, 30.2 mmol) was dissolved in acetic acid (140 mL). An aqueous solution of sodium nitrite (2.1 g, 30.2 mmol) was added slowly and dropwise (3.5 mL) to the reaction mixture under cooling in an ice bath. After removing the ice bath, the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, about half of the solvent was removed by evaporation, and the remaining mixture was diluted with water (80 mL) and extracted with ethyl acetate (3 x 30 mL). The organic phases were combined, washed sequentially with water and saturated saline (2×200 mL each), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the product A-2 (4.4 g, 83% yield). LCMS (ESI): calculated value for C9H8N2O2, [M + H]+: 177, measured value: 177.

References

[1] Patent: WO2008/61109, 2008, A2. Location in patent: Page/Page column 29-30
[2] Patent: WO2014/26328, 2014, A1. Location in patent: Page/Page column 39-40
[3] Patent: WO2014/28597, 2014, A2. Location in patent: Page/Page column 56
[4] Patent: WO2014/26327, 2014, A1. Location in patent: Page/Page column 59
[5] Patent: WO2014/28600, 2014, A2. Location in patent: Page/Page column 50; 51

Methyl 1H-indazole-6-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl 1H-indazole-6-carboxylate manufacturers

Hebei Fengjia New Material Co., Ltd

Product: Methyl 1H-indazole-6-carboxylate 170487-40-8
Price: US $120.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000000
Release date: 2024-08-15

Hebei Chuanghai Biotechnology Co., Ltd

Product: Methyl 1H-indazole-6-carboxylate 170487-40-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

Henan Aochuang Chemical Co.,Ltd.

Product: Methyl 1H-indazole-6-carboxylate 170487-40-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

170487-40-8, Methyl 1H-indazole-6-carboxylateRelated Search:

1H-Indazole-6-carboxylic acid Methyl ester

1H-Indazole-6-carboxylic acid methyl ester

METHYL 1H-INDAZOLE-6-CARBOXYLATE

INDAZOLE-6-CARBOXYLIC ACID METHYL ESTER

6-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER

1H-Indazole-6-carboxylic acid methyl ester

Methyl indazole-6-carboxylate

Methyl indazole-6-carboxy...

1H-indazole-6-carboxylate

1H-Indazole-6-carboxylic acid methyl ester, 6-(Methoxycarbonyl)-1H-indole

1H-Indazole-6-carboxylic acid Methyl ester

1H-Indazole-6-carboxylic acid methyl

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Methyl 1H-indazol-6-carboxylate

170487-40-8